FR2521993B1 - NITROGEN HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE AS HISTAMINE ANTAGONISTS - Google Patents

NITROGEN HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE AS HISTAMINE ANTAGONISTS

Info

Publication number
FR2521993B1
FR2521993B1 FR8303011A FR8303011A FR2521993B1 FR 2521993 B1 FR2521993 B1 FR 2521993B1 FR 8303011 A FR8303011 A FR 8303011A FR 8303011 A FR8303011 A FR 8303011A FR 2521993 B1 FR2521993 B1 FR 2521993B1
Authority
FR
France
Prior art keywords
preparation
therapeutic use
heterocyclic compounds
nitrogen heterocyclic
histamine antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8303011A
Other languages
French (fr)
Other versions
FR2521993A1 (en
Inventor
John Watson Clitherow
Barry John Price
Roger Hayes
David Edmund Bays
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2521993A1 publication Critical patent/FR2521993A1/en
Application granted granted Critical
Publication of FR2521993B1 publication Critical patent/FR2521993B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
FR8303011A 1982-02-24 1983-02-24 NITROGEN HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE AS HISTAMINE ANTAGONISTS Expired FR2521993B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8205431 1982-02-24
GB8205723 1982-02-26

Publications (2)

Publication Number Publication Date
FR2521993A1 FR2521993A1 (en) 1983-08-26
FR2521993B1 true FR2521993B1 (en) 1988-09-16

Family

ID=26282061

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8303011A Expired FR2521993B1 (en) 1982-02-24 1983-02-24 NITROGEN HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE AS HISTAMINE ANTAGONISTS

Country Status (18)

Country Link
JP (1) JPS58157772A (en)
AU (1) AU1180383A (en)
BE (1) BE896012A (en)
DE (1) DE3306503A1 (en)
DK (1) DK88283A (en)
ES (2) ES520031A0 (en)
FI (1) FI830609L (en)
FR (1) FR2521993B1 (en)
GB (1) GB2116178B (en)
GR (1) GR77048B (en)
IL (1) IL67990A0 (en)
IT (1) IT1167622B (en)
LU (1) LU84659A1 (en)
NL (1) NL8300697A (en)
NO (1) NO830643L (en)
NZ (1) NZ203384A (en)
PT (1) PT76280A (en)
SE (1) SE8301039L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336410A1 (en) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg SULFEN AMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
FR2815346B1 (en) * 2000-10-13 2004-02-20 Servier Lab NOVEL AMINOTRIAZOLONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0016565B1 (en) * 1979-03-02 1984-05-23 Glaxo Group Limited 1,2,4-triazole derivatives, processes for their production and pharmaceutical compositions containing them
GB2063874B (en) * 1979-10-22 1983-09-28 Glaxo Group Ltd Triazole derivatives processes for the preparation thereof and pharmaceutical compositions containing them
GB2063253B (en) * 1979-10-22 1983-09-14 Glaxo Group Ltd Triazole derivatives processes for their production and pharmaceutical compositions containing them
DE3068712D1 (en) * 1979-10-23 1984-08-30 Glaxo Group Ltd Aminoalkyl compounds, their production and pharmaceutical compositions containing them
FR2477150A1 (en) * 1980-02-28 1981-09-04 Glaxo Group Ltd NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

Also Published As

Publication number Publication date
DE3306503A1 (en) 1983-09-01
GB2116178A (en) 1983-09-21
IT8347786A0 (en) 1983-02-24
IL67990A0 (en) 1983-06-15
BE896012A (en) 1983-08-24
ES526532A0 (en) 1985-11-16
SE8301039L (en) 1983-08-25
NZ203384A (en) 1985-08-16
ES8602702A1 (en) 1985-11-16
JPS58157772A (en) 1983-09-19
GR77048B (en) 1984-09-04
AU1180383A (en) 1983-09-01
IT1167622B (en) 1987-05-13
FI830609A0 (en) 1983-02-24
ES8407030A1 (en) 1984-04-01
DK88283A (en) 1983-08-25
PT76280A (en) 1983-03-01
NL8300697A (en) 1983-09-16
NO830643L (en) 1983-08-25
FR2521993A1 (en) 1983-08-26
GB2116178B (en) 1985-10-02
DK88283D0 (en) 1983-02-24
LU84659A1 (en) 1984-11-08
ES520031A0 (en) 1984-04-01
FI830609L (en) 1983-08-25
SE8301039D0 (en) 1983-02-24
GB8305147D0 (en) 1983-03-30

Similar Documents

Publication Publication Date Title
FR2487349B1 (en) HYDRONAPHTHALENE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2530630B1 (en) HETEROAROMATIC CHLORACETAMIDES, THEIR PREPARATION, THEIR USE AS HERBICIDES
FR2566414B1 (en) POLYMERIC COMPOUNDS OF QUATERNARY AMMONIUM, THEIR PREPARATION AND THEIR USE
LU80886A1 (en) 6-N-PROPYL-8-METHOXYMETHYL OR METHYLMERCAPTOMETHYLERGOLINES AND RELATED COMPOUNDS, AND THEIR THERAPEUTIC USE
BE890024A (en) TRICYCLIC IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USES
IL83812A (en) Heterocyclic compounds,their preparation and their use as insecticides
FR2537980B1 (en) OLIGOMERIC HYDROXYCARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE
BE872502R (en) QUATERNARY IMIDAZOLIUM COMPOUNDS, THEIR PREPARATION AND USE
BE894046A (en) ERGOPEPTIDE ALKALOIDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
BE839038A (en) QUATERNARY IMIDAZOLIUM COMPOUNDS, THEIR PREPARATION AND USE
DE3369682D1 (en) 2-substituted 1-aminoalkyl-1,2,3,4-tetrahydro-beta-carbolines, their preparation and use as medicaments
ZA801002B (en) Histamine antagonists
FR2607502B1 (en) IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND MEDICINAL COMPOSITIONS CONTAINING THEM
ZA855072B (en) Heterocyclic pharmaceutical compounds,preparation and use
FR2527608B1 (en) NOVEL HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
MC1673A1 (en) ARYLIC DERIVATIVES OF IMIDAZOLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF DRUGS
FR2521993B1 (en) NITROGEN HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR THERAPEUTIC USE AS HISTAMINE ANTAGONISTS
FR2616148B1 (en) NOVEL HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS HERBICIDES
FR2523967B1 (en) HETEROAROMATIC CHLORACETAMIDES, THEIR PREPARATION, THEIR USE AS HERBICIDES
IL82172A0 (en) Heterocyclic organosilyl compounds,their preparation and their use as microbicides
IT8319192A0 (en) 1,3,4-THIADIAZOLE [3,2-A] SUBSTITUTED PYRIMIDINES AND PROCEDURE FOR THEIR PREPARATION
FR2519982B1 (en) NOVEL INDOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
FI834429A0 (en) FRAMSTAELLNING OCH THERAPEUTIC TILLAEMPNING AV 3 ', 5'-DIARABINOSIDER
IT1164633B (en) 3,4-DIAMMINO-1,2,5-TIADIAZOLI EQUIPPED WITH ANTAGONIST ACTIVITY OF HISTAMINE RECEPTORS
BE879732A (en) ACYL-1H-1,2,4-TRIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE

Legal Events

Date Code Title Description
ST Notification of lapse