ES8407030A1 - Heterocyclic derivatives - Google Patents

Heterocyclic derivatives

Info

Publication number
ES8407030A1
ES8407030A1 ES520031A ES520031A ES8407030A1 ES 8407030 A1 ES8407030 A1 ES 8407030A1 ES 520031 A ES520031 A ES 520031A ES 520031 A ES520031 A ES 520031A ES 8407030 A1 ES8407030 A1 ES 8407030A1
Authority
ES
Spain
Prior art keywords
alkyl
group
substituted
oxygen
sulphur
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520031A
Other languages
Spanish (es)
Other versions
ES520031A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8407030A1 publication Critical patent/ES8407030A1/en
Publication of ES520031A0 publication Critical patent/ES520031A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the formula (I):- < IMAGE > and physiologically acceptable salts, hydrates and bioprecursors thereof have been found to show pharmacological activity as selective histamine H2-antagonists. In formula (I> R1 represents hydrogen, C1-14 alkyl, cycloalkyl, alkenyl, aralkyl, heteroaralkyl, trifluoroalkyl or substituted alkyl and R2 represents hydrogen or C1-4 alkyl or R1 and R2 together complete an optionally substituted 5 to 10 membered ring Alk represents C1-3 alkylene Q represents a furan or thiophene bonded via the 2- and 5- positions, the furan or thiophene ring optionally bearing a further substituent R4 adjacent to the group R1R2N-Alk- or Q represents a thiophene ring bonded via the 2- and 4- positions, the thiophene ring optionally bearing a further substituent R4 adjacent to the group R1R2NAlk with the proviso that when the group R1R2 NAlk is in the 4- position then the group R4 is in the 5-position or Q represents a benzene ring bonded via the 1- and 3- or 1- and 4-positions R4 represents halogen or C1-4 alkyl which may be substituted by hydroxy or C1-4 alkoxy X represents oxygen, sulphur-, -NH-, methylene or a bond Y represents oxygen, sulphur, methylene or a bond n represents zero, 1, 2 or 3 and m is an integer from 2 to 5, with the provisos that (a) the total number of atoms in the chain X(CH2)nY(CH2)m is an integer from 3 to 8, (b) when X and Y represents oxygen or sulphur then n is 2 or 3, (c) when X represents -NH- then Q is a benzene ring and Y represents methylene or a bond, and (d) when Q represents a benzene ring, X represents oxygen, and n represents 1, then m may additionally represent 1 and Y may additionally represent -CHOR14 where R14 represents hydrogen or acyl and R3 represents hydrogen, alkyl, alkenyl, aralkyl, or C2-6 alkyl substituted by hydroxy or alkoxy either A represents N and B min represents CR5 or A represents CR5 and B represents N and R5 represents one of various defined substituents.
ES520031A 1982-02-24 1983-02-23 A PROCEDURE FOR PREPARATION OF TRIAZOLE DERIVATIVES. Granted ES520031A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8205431 1982-02-24
GB8205723 1982-02-26

Publications (2)

Publication Number Publication Date
ES8407030A1 true ES8407030A1 (en) 1984-04-01
ES520031A0 ES520031A0 (en) 1984-04-01

Family

ID=26282061

Family Applications (2)

Application Number Title Priority Date Filing Date
ES520031A Granted ES520031A0 (en) 1982-02-24 1983-02-23 A PROCEDURE FOR PREPARATION OF TRIAZOLE DERIVATIVES.
ES526532A Granted ES526532A0 (en) 1982-02-24 1983-10-17 A PROCEDURE FOR THE PREPARATION OF TRIAZOLE DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES526532A Granted ES526532A0 (en) 1982-02-24 1983-10-17 A PROCEDURE FOR THE PREPARATION OF TRIAZOLE DERIVATIVES

Country Status (18)

Country Link
JP (1) JPS58157772A (en)
AU (1) AU1180383A (en)
BE (1) BE896012A (en)
DE (1) DE3306503A1 (en)
DK (1) DK88283A (en)
ES (2) ES520031A0 (en)
FI (1) FI830609L (en)
FR (1) FR2521993B1 (en)
GB (1) GB2116178B (en)
GR (1) GR77048B (en)
IL (1) IL67990A0 (en)
IT (1) IT1167622B (en)
LU (1) LU84659A1 (en)
NL (1) NL8300697A (en)
NO (1) NO830643L (en)
NZ (1) NZ203384A (en)
PT (1) PT76280A (en)
SE (1) SE8301039L (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336410A1 (en) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg SULFEN AMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
FR2815346B1 (en) * 2000-10-13 2004-02-20 Servier Lab NOVEL AMINOTRIAZOLONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU56680A (en) * 1979-03-02 1983-04-30 Glaxo Group Ltd Process for obtaining new 1,2,4-triazole derivatives
US4410523A (en) * 1979-10-22 1983-10-18 Glaxo Group Limited Heterocyclic derivatives
AU539189B2 (en) * 1979-10-22 1984-09-13 Glaxo Group Limited 1h-1,2,4-triazole derivatives
DE3068712D1 (en) * 1979-10-23 1984-08-30 Glaxo Group Ltd Aminoalkyl compounds, their production and pharmaceutical compositions containing them
FR2477150A1 (en) * 1980-02-28 1981-09-04 Glaxo Group Ltd NOVEL HETEROCYCLIC DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

Also Published As

Publication number Publication date
DK88283A (en) 1983-08-25
NL8300697A (en) 1983-09-16
ES520031A0 (en) 1984-04-01
PT76280A (en) 1983-03-01
IT8347786A0 (en) 1983-02-24
DK88283D0 (en) 1983-02-24
IL67990A0 (en) 1983-06-15
JPS58157772A (en) 1983-09-19
FR2521993B1 (en) 1988-09-16
AU1180383A (en) 1983-09-01
SE8301039D0 (en) 1983-02-24
FI830609A0 (en) 1983-02-24
NZ203384A (en) 1985-08-16
GB8305147D0 (en) 1983-03-30
IT1167622B (en) 1987-05-13
BE896012A (en) 1983-08-24
GR77048B (en) 1984-09-04
GB2116178B (en) 1985-10-02
LU84659A1 (en) 1984-11-08
ES8602702A1 (en) 1985-11-16
FR2521993A1 (en) 1983-08-26
GB2116178A (en) 1983-09-21
SE8301039L (en) 1983-08-25
DE3306503A1 (en) 1983-09-01
NO830643L (en) 1983-08-25
ES526532A0 (en) 1985-11-16
FI830609L (en) 1983-08-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980302