SE8300870L - INTERMEDIATES FOR PREPARING DERIVATIVES OF 4 "-DESOXY-4" -AMINO-ERYTHROMYCINE A - Google Patents

INTERMEDIATES FOR PREPARING DERIVATIVES OF 4 "-DESOXY-4" -AMINO-ERYTHROMYCINE A

Info

Publication number
SE8300870L
SE8300870L SE8300870A SE8300870A SE8300870L SE 8300870 L SE8300870 L SE 8300870L SE 8300870 A SE8300870 A SE 8300870A SE 8300870 A SE8300870 A SE 8300870A SE 8300870 L SE8300870 L SE 8300870L
Authority
SE
Sweden
Prior art keywords
intermediates
erythromycine
desoxy
amino
preparing derivatives
Prior art date
Application number
SE8300870A
Other languages
Swedish (sv)
Other versions
SE457086B (en
SE8300870D0 (en
Inventor
F C Sciavolino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/856,479 external-priority patent/US4150220A/en
Application filed by Pfizer filed Critical Pfizer
Publication of SE8300870L publication Critical patent/SE8300870L/en
Publication of SE8300870D0 publication Critical patent/SE8300870D0/en
Publication of SE457086B publication Critical patent/SE457086B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

New semi-synthetic derivatives of 4''-erythromycin A and their preparation are described. The new compounds of the invention correspond to the formulae I and II in which the symbols have the meaning given in Claim 1. The compounds of formulae I and II, in which X and Y are a pair H, NH2, possess antibacterial properties and can be used as medicinal products.

Claims (2)

ratentkmavratentkmav 1. Mellanprodukter for framstallning av derivat av 4.-desomi-4"-dmino-erytromycin A, kannete_ck- nadaddrav, au t de har.forMeln II ddr Ri representerar vdte eller alkanmyl med 2-3 kmlatomer; 0Intermediates for the preparation of derivatives of 4-desomium-4 "-dmino-erythromycin A, cinnamon derivatives, from which they have formula II or R 1 represents hydrogen or alkane methyl having 2-3 km atoms; 2. representeraralkanmyl Med 2-3 kmlatmmer; Y representerar NH, S-OH eller M-0-FCH3; 03 representerar Irate; och 02 och 03 tillsammans kan representera2. represents alkanmyl Med 2-3 kmlatmmer; Y represents NH, S-OH or M-O-FCH3; 03 represents Irate; and 02 and 03 together may represent
SE8300870A 1977-02-04 1983-02-16 ERYTROMYCINE A DERIVATIVES FOR USE AS INTERMEDIATES FOR THE PREPARATION OF THERAPEUTIC APPLICABLE DERIVATIVES OF 4 "-DESOXY-4" -AMINOERYTROMYCINE A SE457086B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76548077A 1977-02-04 1977-02-04
US05/856,479 US4150220A (en) 1977-02-04 1977-12-01 Semi-synthetic 4"-erythromycin A derivatives

Publications (3)

Publication Number Publication Date
SE8300870L true SE8300870L (en) 1983-02-16
SE8300870D0 SE8300870D0 (en) 1983-02-16
SE457086B SE457086B (en) 1988-11-28

Family

ID=27117613

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7800270A SE445223B (en) 1977-02-04 1978-01-10 SET TO PREPARE 4 "-AMINO-ERYTHOMYLIN-A-DERIVATE
SE8300870A SE457086B (en) 1977-02-04 1983-02-16 ERYTROMYCINE A DERIVATIVES FOR USE AS INTERMEDIATES FOR THE PREPARATION OF THERAPEUTIC APPLICABLE DERIVATIVES OF 4 "-DESOXY-4" -AMINOERYTROMYCINE A

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7800270A SE445223B (en) 1977-02-04 1978-01-10 SET TO PREPARE 4 "-AMINO-ERYTHOMYLIN-A-DERIVATE

Country Status (30)

Country Link
JP (1) JPS5827798B2 (en)
AR (1) AR222147A1 (en)
AU (1) AU501298B1 (en)
BG (2) BG32718A3 (en)
CA (1) CA1106367A (en)
CH (1) CH628906A5 (en)
CS (1) CS221801B2 (en)
DD (1) DD140048A5 (en)
DE (1) DE2804507C2 (en)
DK (1) DK148036C (en)
ES (2) ES466057A1 (en)
FI (1) FI780354A (en)
FR (2) FR2379550A1 (en)
GB (2) GB1585316A (en)
GR (1) GR68691B (en)
HU (1) HU182559B (en)
IE (1) IE46661B1 (en)
IL (2) IL53968A0 (en)
IT (1) IT1094209B (en)
LU (1) LU79004A1 (en)
NL (1) NL176174C (en)
NO (2) NO146472C (en)
NZ (1) NZ186385A (en)
PH (2) PH14421A (en)
PL (1) PL116228B1 (en)
PT (1) PT67568B (en)
RO (4) RO77345A (en)
SE (2) SE445223B (en)
SU (1) SU927122A3 (en)
YU (3) YU40913B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124755A (en) * 1978-01-03 1978-11-07 Pfizer Inc. 11-Alkanoyl-4"-deoxy-4"-isonitrilo-oleandomycin derivatives
US4133950A (en) * 1978-01-03 1979-01-09 Pfizer Inc. 4"-Deoxy-4"-carbamate and dithiocarbamate derivatives of oleandomycin and its esters
US4382085A (en) * 1982-03-01 1983-05-03 Pfizer Inc. 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
US4518590A (en) * 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
HN1998000074A (en) * 1997-06-11 1999-01-08 Pfizer Prod Inc DERIVATIVES FROM MACROLIDES C-4 SUBSTITUTED
US6407074B1 (en) 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3836519A (en) * 1973-05-04 1974-09-17 Abbott Lab Sulfonyl derivatives of erythromycin
US3884903A (en) * 1973-06-21 1975-05-20 Abbott Lab 4{41 -Deoxy-4{41 -oxoerythromycin B derivatives

Also Published As

Publication number Publication date
FR2385735B1 (en) 1980-10-24
GR68691B (en) 1982-02-01
FR2385735A1 (en) 1978-10-27
NO146472B (en) 1982-06-28
RO81622A (en) 1983-04-29
HU182559B (en) 1984-02-28
IT7820005A0 (en) 1978-02-03
ES472429A1 (en) 1979-04-01
YU40799B (en) 1986-06-30
DK51878A (en) 1978-08-05
PH14421A (en) 1981-07-10
NL176174B (en) 1984-10-01
NO150484C (en) 1984-10-24
IL53968A0 (en) 1978-04-30
PT67568B (en) 1979-06-18
RO79687A7 (en) 1982-08-17
SE445223B (en) 1986-06-09
GB1585315A (en) 1981-02-25
IE780239L (en) 1978-08-04
RO81622B (en) 1983-04-30
NL176174C (en) 1985-03-01
PT67568A (en) 1978-02-01
AU501298B1 (en) 1979-06-14
BG33159A3 (en) 1982-12-15
YU227983A (en) 1984-04-30
IL61997A0 (en) 1981-02-27
SE457086B (en) 1988-11-28
CS221801B2 (en) 1983-04-29
FR2379550A1 (en) 1978-09-01
LU79004A1 (en) 1979-09-06
YU40798B (en) 1986-06-30
PL204428A1 (en) 1979-06-04
RO79686A7 (en) 1982-08-17
YU40913B (en) 1986-08-31
ES466057A1 (en) 1978-10-01
FR2379550B1 (en) 1980-07-04
IE46661B1 (en) 1983-08-24
CA1106367A (en) 1981-08-04
BG32718A3 (en) 1982-09-15
SE8300870D0 (en) 1983-02-16
CH628906A5 (en) 1982-03-31
NO150484B (en) 1984-07-16
NO780389L (en) 1978-08-07
YU7378A (en) 1983-04-30
FI780354A (en) 1978-08-05
DE2804507C2 (en) 1982-11-04
YU26583A (en) 1984-02-29
DD140048A5 (en) 1980-02-06
DE2804507A1 (en) 1978-08-10
GB1585316A (en) 1981-02-25
NO146472C (en) 1982-10-06
RO77345A (en) 1981-08-17
DK148036C (en) 1985-07-15
NL7801262A (en) 1978-08-08
DK148036B (en) 1985-02-11
SU927122A3 (en) 1982-05-07
PL116228B1 (en) 1981-05-30
SE7800270L (en) 1978-08-05
PH16675A (en) 1983-12-13
NO811913L (en) 1978-08-07
AR222147A1 (en) 1981-04-30
NZ186385A (en) 1980-10-08
IT1094209B (en) 1985-07-26
JPS5827798B2 (en) 1983-06-11
JPS53101337A (en) 1978-09-04

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