SE8206981L - N- (VINBLASTONYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS - Google Patents

N- (VINBLASTONYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS

Info

Publication number
SE8206981L
SE8206981L SE8206981A SE8206981A SE8206981L SE 8206981 L SE8206981 L SE 8206981L SE 8206981 A SE8206981 A SE 8206981A SE 8206981 A SE8206981 A SE 8206981A SE 8206981 L SE8206981 L SE 8206981L
Authority
SE
Sweden
Prior art keywords
group
hydrogen atom
derivatives
vinblastonyl
preparation
Prior art date
Application number
SE8206981A
Other languages
Swedish (sv)
Other versions
SE452622B (en
SE8206981D0 (en
Inventor
A B L Trovet
J A A J Hannart
K S B Rao
Original Assignee
Omnichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem Sa filed Critical Omnichem Sa
Publication of SE8206981D0 publication Critical patent/SE8206981D0/en
Publication of SE8206981L publication Critical patent/SE8206981L/en
Publication of SE452622B publication Critical patent/SE452622B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Vinblastine derivatives of the general formula: <IMAGE> wherein R is an ester of an amino-acid which is possibly protected, attached to the vinblastin-23-oyl moiety by an amide bond, the ester group, which may be straight or branched, containing 2-9 carbon atoms and R1 is a hydrogen atom or a hydroxy group, R2 is a hydrogen atom, a formyl group or a C2-C9 acyl group, R5 is a hydrogen atom or a methyl group or a formyl group, with the provision that compounds where R5 is methyl and R1 is a beta -hydroxy group are excluded; or their addition salts with mineral or organic acids. The compounds are useful as drugs.
SE8206981A 1981-12-08 1982-12-07 N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS SE452622B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU83822A LU83822A1 (en) 1981-12-08 1981-12-08 N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (3)

Publication Number Publication Date
SE8206981D0 SE8206981D0 (en) 1982-12-07
SE8206981L true SE8206981L (en) 1983-06-09
SE452622B SE452622B (en) 1987-12-07

Family

ID=19729780

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8206981A SE452622B (en) 1981-12-08 1982-12-07 N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS

Country Status (24)

Country Link
JP (1) JPS58116491A (en)
AT (1) AT390958B (en)
AU (1) AU564951B2 (en)
BE (1) BE895262A (en)
CA (1) CA1198422A (en)
CH (1) CH655727A5 (en)
DD (1) DD205906A5 (en)
DE (1) DE3245269A1 (en)
DK (1) DK161833C (en)
ES (1) ES8401768A1 (en)
FR (1) FR2517680B1 (en)
GB (1) GB2111055B (en)
GR (1) GR77280B (en)
HU (1) HU187803B (en)
IE (1) IE55283B1 (en)
IL (1) IL67366A (en)
IT (1) IT1157126B (en)
LU (1) LU83822A1 (en)
NL (1) NL8204711A (en)
NZ (1) NZ202708A (en)
OA (1) OA07270A (en)
PT (1) PT75949B (en)
SE (1) SE452622B (en)
ZA (1) ZA828823B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR81790B (en) * 1983-04-29 1984-12-12 Omnichem Sa
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
CA1335686C (en) * 1986-01-13 1995-05-23 Rao K. S. P. Bhushana Vinblastin and pharmaceutical composition comprising them
US4906086A (en) * 1987-06-19 1990-03-06 Honda Giken Kogyo Kabushiki Kaisha Rearview mirror device for motorcycles
FR2626882B1 (en) * 1988-02-08 1991-11-08 Ire Celltarg Sa VINCA DERIVATIVE CONJUGATES COMPRISING A DETERGENT CHAIN IN POSITION C-3
CN105121447B (en) * 2013-04-19 2018-02-02 暨南大学 Vinca derivative and its preparation method and application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (en) 1973-04-02 1975-11-12 Lilly Co Eli PROCEDURES FOR PREPARING VINBLASTIN LEUROSIDINE AND LEUROCRISTINE DERIVATIVES
US3848234A (en) * 1973-04-04 1974-11-12 Sperry Rand Corp Multi-processor system with multiple cache memories
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
OA06421A (en) * 1980-06-10 1981-09-30 Omnium Chimique Sa Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.

Also Published As

Publication number Publication date
FR2517680B1 (en) 1990-05-25
NL8204711A (en) 1983-07-01
ATA444982A (en) 1990-01-15
SE452622B (en) 1987-12-07
IT1157126B (en) 1987-02-11
BE895262A (en) 1983-06-07
AU564951B2 (en) 1987-09-03
IT8268431A0 (en) 1982-12-07
LU83822A1 (en) 1983-09-01
JPH0449557B2 (en) 1992-08-11
CH655727A5 (en) 1986-05-15
PT75949B (en) 1985-10-04
IE822906L (en) 1983-06-08
DE3245269A1 (en) 1983-07-21
DK161833B (en) 1991-08-19
IE55283B1 (en) 1990-08-01
JPS58116491A (en) 1983-07-11
DD205906A5 (en) 1984-01-11
ES517942A0 (en) 1984-01-01
OA07270A (en) 1984-04-30
NZ202708A (en) 1986-01-24
GB2111055A (en) 1983-06-29
DK541882A (en) 1983-06-09
IL67366A0 (en) 1983-03-31
HU187803B (en) 1986-02-28
GB2111055B (en) 1985-07-10
FR2517680A1 (en) 1983-06-10
ES8401768A1 (en) 1984-01-01
CA1198422A (en) 1985-12-24
AU9084782A (en) 1983-06-16
PT75949A (en) 1983-01-01
DK161833C (en) 1992-01-20
GR77280B (en) 1984-09-11
SE8206981D0 (en) 1982-12-07
ZA828823B (en) 1983-09-28
IL67366A (en) 1987-01-30
AT390958B (en) 1990-07-25

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