SE8206445L - ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DI-N-PROPYLMethylamine derivatives - Google Patents

ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DI-N-PROPYLMethylamine derivatives

Info

Publication number
SE8206445L
SE8206445L SE8206445A SE8206445A SE8206445L SE 8206445 L SE8206445 L SE 8206445L SE 8206445 A SE8206445 A SE 8206445A SE 8206445 A SE8206445 A SE 8206445A SE 8206445 L SE8206445 L SE 8206445L
Authority
SE
Sweden
Prior art keywords
preparation
acid addition
derivatives
propyl
reacted
Prior art date
Application number
SE8206445A
Other languages
Swedish (sv)
Other versions
SE8206445D0 (en
SE452763B (en
Inventor
C Pigerol
P Eymard
M Broll
J-C Vernieres
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SE8206445L publication Critical patent/SE8206445L/en
Publication of SE8206445D0 publication Critical patent/SE8206445D0/en
Publication of SE452763B publication Critical patent/SE452763B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

(21)Ans nr 8206445-2 Rotel 8206 (51)Klass C 07 0 205/04 C 07 0 203/08 (74)0mbud HArne Patentkrav van i R och n har samma betydelse som oven, eller med ett syraadditionssalt av deems firening, corn ger det Onskade metylaminderivatet som sedan kan reageras med Wagon organisk eller oorganisk syra till ett farmaceutiskt godtagbart syraadditionssalt av derivatet. 1. Analogiforfarande fir framstallning av nya di-n-propyl-metylaminderivat med den generella formeln RC-N(C112)fl /rn-C3R, och de farmaceutiskt godtagbara syraadditionssalterna darav, vani R betecknar n-propyl, isopropyl, isobutyl eller allyl och n an 0 eller 1,kHnnetecknatav au t ett lampligt cykliseringsmedel reageras i ett losningsmedel eller i franvaro av nagot losningsmedel med en alkohol med den generella formeln: RC-NH-C112-110CH2OH n-030 II (21) Ans nr 8206445-2 Rotel 8206 (51) Klass C 07 0 205/04 C 07 0 203/08 (74) 0mbud HArne , corn gives the desired methylamine derivative which can then be reacted with Wagon organic or inorganic acid to form a pharmaceutically acceptable acid addition salt of the derivative. An analogous process for the preparation of novel di-n-propyl-methylamine derivatives of the general formula RC-N (C112) fl / rn-C3R, and the pharmaceutically acceptable acid addition salts thereof, vani R represents n-propyl, isopropyl, isobutyl or allyl and n 0 or 1, the characteristic sign of a suitable cyclizing agent is reacted in a solvent or in the absence of any solvent with an alcohol of the general formula: RC-NH-C112-110CH 2 OH n-030 II

Claims (1)

Patentkrav van i R och n har samma betydelse som oven, eller med ett syraadditionssalt av deems firening, corn ger det Onskade metylaminderivatet som sedan kan reageras med Wagon organisk eller oorganisk syra till ett farmaceutiskt godtagbart syraadditionssalt av derivatet.Claims van in R and n have the same meaning as above, or with an acid addition salt of their compound, corn gives the desired methylamine derivative which can then be reacted with Wagon organic or inorganic acid to a pharmaceutically acceptable acid addition salt of the derivative. 1. Analogiforfarande fir framstallning av nya di-n-propyl-metylaminderivat med den generella formeln RC-N(C112)fl /rn-C3R, och de farmaceutiskt godtagbara syraadditionssalterna darav, vani R betecknar n-propyl, isopropyl, isobutyl eller allyl och n an 0 eller 1,kHnnetecknatav au t ett lampligt cykliseringsmedel reageras i ett losningsmedel eller i franvaro av nagot losningsmedel med en alkohol med den generella formeln: RC-NH-C112-110CH2OH n-030 IIAn analogous process for the preparation of novel di-n-propyl-methylamine derivatives of the general formula RC-N (C112) fl / rn-C3R, and the pharmaceutically acceptable acid addition salts thereof, vani R represents n-propyl, isopropyl, isobutyl or allyl and n 0 or 1, the characteristic sign of a suitable cyclizing agent is reacted in a solvent or in the absence of any solvent with an alcohol of the general formula: RC-NH-C112-110CH 2 OH n-030 II
SE8206445A 1976-06-03 1982-11-12 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DI-N-PROPYL-METHYLAMINE DERIVATIVES SE452763B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE842528 1976-06-03

Publications (3)

Publication Number Publication Date
SE8206445L true SE8206445L (en) 1982-11-12
SE8206445D0 SE8206445D0 (en) 1982-11-12
SE452763B SE452763B (en) 1987-12-14

Family

ID=3861370

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7706448A SE452317B (en) 1976-06-03 1977-06-02 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE, NEW DI-N-PROPYL-METHYLAMINE DERIVATIVES
SE8206445A SE452763B (en) 1976-06-03 1982-11-12 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE DI-N-PROPYL-METHYLAMINE DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7706448A SE452317B (en) 1976-06-03 1977-06-02 ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE, NEW DI-N-PROPYL-METHYLAMINE DERIVATIVES

Country Status (17)

Country Link
JP (1) JPS6039261B2 (en)
AR (4) AR213646A1 (en)
AT (1) AT352088B (en)
AU (1) AU511705B2 (en)
DK (1) DK146063C (en)
ES (2) ES459466A1 (en)
FI (1) FI63015C (en)
FR (2) FR2374901A1 (en)
GR (1) GR61148B (en)
MX (1) MX4778E (en)
NL (1) NL7706052A (en)
NO (1) NO145337C (en)
NZ (1) NZ184161A (en)
PT (1) PT66623B (en)
SE (2) SE452317B (en)
YU (1) YU129577A (en)
ZA (1) ZA773151B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE815273A (en) * 1974-05-20 1974-11-20 METHYLAMINE ACTIVE DERIVATIVES
BE842528R (en) * 1976-06-03 1976-12-03 METHYLAMINE ACTIVE DERIVATIVES, THERAPEUTIC COMPOSITIONS CONTAINING THEM AND THE PROCESSES FOR THE PREPARATION OF THESE DERIVATIVES AND COMPOSITIONS

Also Published As

Publication number Publication date
AU2556177A (en) 1978-11-30
DK146063C (en) 1983-11-14
ES459466A1 (en) 1978-08-16
PT66623B (en) 1978-11-07
AR213646A1 (en) 1979-02-28
NZ184161A (en) 1980-10-08
FR2372795B1 (en) 1983-08-12
FI63015B (en) 1982-12-31
AT352088B (en) 1979-08-27
ES470379A1 (en) 1979-10-16
NO145337C (en) 1982-03-03
AU511705B2 (en) 1980-09-04
AR215052A1 (en) 1979-08-31
JPS6039261B2 (en) 1985-09-05
ZA773151B (en) 1978-04-26
NO771941L (en) 1977-12-06
AR215175A1 (en) 1979-09-14
PT66623A (en) 1977-07-01
SE8206445D0 (en) 1982-11-12
FI771780A (en) 1977-12-04
FR2372795A1 (en) 1978-06-30
GR61148B (en) 1978-09-27
NO145337B (en) 1981-11-23
AR215053A1 (en) 1979-08-31
DK146063B (en) 1983-06-20
JPS52148006A (en) 1977-12-08
FR2374901B1 (en) 1981-04-17
ATA395877A (en) 1979-02-15
NL7706052A (en) 1977-12-06
SE7706448L (en) 1977-12-04
FR2374901A1 (en) 1978-07-21
SE452763B (en) 1987-12-14
FI63015C (en) 1983-04-11
DK244677A (en) 1977-12-04
YU129577A (en) 1983-01-21
SE452317B (en) 1987-11-23
MX4778E (en) 1982-09-15

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