ES470379A1 - Methylamine derivatives preparation method and pharmceutical composition containing same - Google Patents

Methylamine derivatives preparation method and pharmceutical composition containing same

Info

Publication number
ES470379A1
ES470379A1 ES470379A ES470379A ES470379A1 ES 470379 A1 ES470379 A1 ES 470379A1 ES 470379 A ES470379 A ES 470379A ES 470379 A ES470379 A ES 470379A ES 470379 A1 ES470379 A1 ES 470379A1
Authority
ES
Spain
Prior art keywords
alkenyl
linear
alkynyl
branched alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470379A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Publication of ES470379A1 publication Critical patent/ES470379A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methylamine derivs. of formula (I) and their addition salts are novel cpds. (where R1, R3 = H or a 1-6C linear or branched alkyl, alkenyl or alkynyl radical R2 = 2-7C, linear or branched alkyl, alkenyl or alkynyl with the condition that when R2=alkenyl of formula -CH=CH-R6 or alkynyl of formula -C=C=R6 (where R6 = H or 1-5C linear or branched alkyl) then R1 and R3 = H or alkyl r4 =H, 1-5C linear or branched alkyl, alkenyl or alkynyl or 2-5C omega-hydroxyalkyl R5 = 1-5C, linear or branched alkyl, alkenyl or alkynyl or 2-5C omega-hydroxyalkyl or R4 and R5 together = 2-6C alkylene, 1-5C alkylidene or -CH2-CH2-O-CH2-CH2- R1, R2 and R3 are such that the trisubstdmethyl radical contains =13C atoms). Used for treatment of Parkinsons disease and correction of extrapyramidal troubles caused by neuroleptics. Pharmacological tests show their central noradrenergic and central dopaminergic activity and they have less side-effects than the cpds. of the parent patent and first addition. They may be administered orally (unit doses 5-50 mg pref. 5-20 mg), rectally (5-100 mg) or parenterally (1-20 mg).
ES470379A 1976-06-03 1978-05-31 Methylamine derivatives preparation method and pharmceutical composition containing same Expired ES470379A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE842528 1976-06-03

Publications (1)

Publication Number Publication Date
ES470379A1 true ES470379A1 (en) 1979-10-16

Family

ID=3861370

Family Applications (2)

Application Number Title Priority Date Filing Date
ES459466A Expired ES459466A1 (en) 1976-06-03 1977-06-03 Methylamine derivatives preparation method and pharmceutical composition containing same
ES470379A Expired ES470379A1 (en) 1976-06-03 1978-05-31 Methylamine derivatives preparation method and pharmceutical composition containing same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES459466A Expired ES459466A1 (en) 1976-06-03 1977-06-03 Methylamine derivatives preparation method and pharmceutical composition containing same

Country Status (17)

Country Link
JP (1) JPS6039261B2 (en)
AR (4) AR213646A1 (en)
AT (1) AT352088B (en)
AU (1) AU511705B2 (en)
DK (1) DK146063C (en)
ES (2) ES459466A1 (en)
FI (1) FI63015C (en)
FR (2) FR2374901A1 (en)
GR (1) GR61148B (en)
MX (1) MX4778E (en)
NL (1) NL7706052A (en)
NO (1) NO145337C (en)
NZ (1) NZ184161A (en)
PT (1) PT66623B (en)
SE (2) SE452317B (en)
YU (1) YU129577A (en)
ZA (1) ZA773151B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES437790A1 (en) * 1974-05-20 1977-05-16 Labaz Therapeutic compositions containing methylamine derivatives or their salts
BE842528R (en) * 1976-06-03 1976-12-03 METHYLAMINE ACTIVE DERIVATIVES, THERAPEUTIC COMPOSITIONS CONTAINING THEM AND THE PROCESSES FOR THE PREPARATION OF THESE DERIVATIVES AND COMPOSITIONS

Also Published As

Publication number Publication date
DK146063B (en) 1983-06-20
NL7706052A (en) 1977-12-06
DK244677A (en) 1977-12-04
NO145337C (en) 1982-03-03
FI63015B (en) 1982-12-31
GR61148B (en) 1978-09-27
FR2372795A1 (en) 1978-06-30
ZA773151B (en) 1978-04-26
YU129577A (en) 1983-01-21
SE452763B (en) 1987-12-14
PT66623B (en) 1978-11-07
SE452317B (en) 1987-11-23
JPS6039261B2 (en) 1985-09-05
AR215052A1 (en) 1979-08-31
NO145337B (en) 1981-11-23
DK146063C (en) 1983-11-14
SE8206445L (en) 1982-11-12
AU511705B2 (en) 1980-09-04
NO771941L (en) 1977-12-06
FR2372795B1 (en) 1983-08-12
PT66623A (en) 1977-07-01
AR215053A1 (en) 1979-08-31
MX4778E (en) 1982-09-15
SE8206445D0 (en) 1982-11-12
AR215175A1 (en) 1979-09-14
SE7706448L (en) 1977-12-04
JPS52148006A (en) 1977-12-08
ES459466A1 (en) 1978-08-16
ATA395877A (en) 1979-02-15
FI771780A (en) 1977-12-04
NZ184161A (en) 1980-10-08
AU2556177A (en) 1978-11-30
AT352088B (en) 1979-08-27
AR213646A1 (en) 1979-02-28
FR2374901A1 (en) 1978-07-21
FI63015C (en) 1983-04-11
FR2374901B1 (en) 1981-04-17

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