SE8201654L - Amido-AMINO ACIDS - Google Patents

Amido-AMINO ACIDS

Info

Publication number
SE8201654L
SE8201654L SE8201654A SE8201654A SE8201654L SE 8201654 L SE8201654 L SE 8201654L SE 8201654 A SE8201654 A SE 8201654A SE 8201654 A SE8201654 A SE 8201654A SE 8201654 L SE8201654 L SE 8201654L
Authority
SE
Sweden
Prior art keywords
lower alkyl
alkylamino
mercapto
amino
inclusive
Prior art date
Application number
SE8201654A
Other languages
Swedish (sv)
Inventor
J T Suh
J N Barton
J R Regan
Original Assignee
Usv Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Pharma Corp filed Critical Usv Pharma Corp
Publication of SE8201654L publication Critical patent/SE8201654L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Compounds of the formula <IMAGE> wherein R1 and R2 are hydrogen, lower alkyl or phenyl lower alkyl, R2, R3, R4, R5 and R6 are independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, fused aryl-cycloalkyl, aralkyl, cycloalkyl, heterocyclic, substituted lower alkyl, lower alkenyl, and lower alkynyl groups wherein the substituent is hydroxy, alkoxy, halo, amino, alkylamino, mercapto and alkylmercapto groups, and substituted cycloalkyl, aryl and heterocyclic groups in which the substituent is alkyl, hydroxy, alkoxy, hydroxyalkyl, halo, mercapto, alkylmercapto, mercaptoalkyl, haloalkyl, amino, alkylamino, aminoalkyl, nitro, methylenedioxy, and trifluoromethyl; each R8 is lower alkyl, lower alkenyl, lower alkynyl, nitro, amino, alkylamino, dialkylamino, hydroxy, alkoxy, mercapto, alkylmercapto, hydroxyalkyl, mercaptoalkyl, halogen, haloalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalky, sulfonamido, methylenedioxy, or trifluoromethyl, m is an integer from 0 to 2 inclusive; m' is an integer from 1 to 3 inclusive, provided that when m is 0, m' is 2 or 3 and, when m is other than 0, m' is 1 or 2; n is an integer from 0 to 4 inclusive, and salts thereof, especially pharmaceutically acceptable salts with an acid or a base.
SE8201654A 1981-03-19 1982-03-16 Amido-AMINO ACIDS SE8201654L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24540781A 1981-03-19 1981-03-19

Publications (1)

Publication Number Publication Date
SE8201654L true SE8201654L (en) 1982-09-20

Family

ID=22926526

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8201654A SE8201654L (en) 1981-03-19 1982-03-16 Amido-AMINO ACIDS

Country Status (21)

Country Link
JP (1) JPS57165355A (en)
KR (1) KR890001146B1 (en)
AU (1) AU558451B2 (en)
BE (1) BE892552A (en)
CH (1) CH658455A5 (en)
DE (1) DE3209708A1 (en)
DK (1) DK120982A (en)
ES (3) ES510498A0 (en)
FI (1) FI820974L (en)
FR (1) FR2502149A1 (en)
GB (1) GB2095252B (en)
IE (1) IE53076B1 (en)
IL (1) IL65247A (en)
IN (1) IN156096B (en)
IT (1) IT1150697B (en)
NL (1) NL8201066A (en)
NO (1) NO820903L (en)
NZ (1) NZ200047A (en)
PH (1) PH18657A (en)
SE (1) SE8201654L (en)
ZA (1) ZA821833B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (en) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3302125A1 (en) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
FI841052A (en) * 1983-03-16 1984-09-17 Usv Pharma Corp FOERENINGAR FOER BEHANDLING AV BLODTRYCKSSJUKDOMAR.
DE3333454A1 (en) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS
DE3622297A1 (en) * 1986-07-03 1988-01-07 Basf Ag DISAZOTHIOPHENE DYES
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
ES2122941B1 (en) * 1997-05-29 1999-07-01 Esteve Quimica Sa PROCEDURE FOR OBTAINING QUINAPRIL CHLORHYDRATE AND SOLVATES USEFUL FOR THE ISOLATION AND PURIFICATION OF QUINAPRIL CHLORHYDRATE.
EP1333026B1 (en) 2002-01-30 2007-06-27 Les Laboratoires Servier Process for the preparation of high purity perindopril and intermediates useful in the synthesis
US7482361B2 (en) 2002-12-16 2009-01-27 Lupin Limited Crystalline form for quinapril hydrochloride and process for preparing the same
CA2517205C (en) * 2003-02-28 2010-08-24 Lupin Limited Process for preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (en) * 1980-10-02 1982-10-08 Science Union & Cie NOVEL SUBSTITUTED IMINO DIACIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
DE3177130D1 (en) * 1980-08-30 1990-01-11 Hoechst Ag AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, MEANS CONTAINING THEM AND THE USE THEREOF.
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application

Also Published As

Publication number Publication date
GB2095252B (en) 1985-04-17
IE820635L (en) 1982-09-19
ES521030A0 (en) 1984-05-16
ES8307718A1 (en) 1983-08-01
IE53076B1 (en) 1988-06-08
IT1150697B (en) 1986-12-17
GB2095252A (en) 1982-09-29
AU8158482A (en) 1982-09-23
PH18657A (en) 1985-08-29
DE3209708A1 (en) 1982-10-21
JPS57165355A (en) 1982-10-12
KR890001146B1 (en) 1989-04-25
IT8220259A0 (en) 1982-03-18
ES8501363A1 (en) 1984-12-01
IN156096B (en) 1985-05-11
ES521031A0 (en) 1984-12-01
ES510498A0 (en) 1983-08-01
CH658455A5 (en) 1986-11-14
IL65247A0 (en) 1982-05-31
DK120982A (en) 1982-09-20
NO820903L (en) 1982-09-20
NL8201066A (en) 1982-10-18
FI820974L (en) 1982-09-20
ZA821833B (en) 1983-01-26
ES8404317A1 (en) 1984-05-16
FR2502149B1 (en) 1985-01-18
AU558451B2 (en) 1987-01-29
NZ200047A (en) 1985-07-12
FR2502149A1 (en) 1982-09-24
IL65247A (en) 1987-07-31
BE892552A (en) 1982-09-20
KR830009065A (en) 1983-12-17

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