SE8201618L - 1-PHENYLTIO-2-AMINOPROPANDER DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND THE USE OF THE SAME - Google Patents
1-PHENYLTIO-2-AMINOPROPANDER DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND THE USE OF THE SAMEInfo
- Publication number
- SE8201618L SE8201618L SE8201618A SE8201618A SE8201618L SE 8201618 L SE8201618 L SE 8201618L SE 8201618 A SE8201618 A SE 8201618A SE 8201618 A SE8201618 A SE 8201618A SE 8201618 L SE8201618 L SE 8201618L
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- reaction
- formula
- halogen
- aminopropander
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- BULLHNJGPPOUOX-UHFFFAOYSA-N chloroacetone Chemical compound CC(=O)CCl BULLHNJGPPOUOX-UHFFFAOYSA-N 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 238000006268 reductive amination reaction Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical class SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NEW MATERIAL:The compound of formulaI(R<1> is halogen; R<2> is H or halogen; R<3> is methyl, ethyl, or hydroxyethyl). EXAMPLE:1-(4-Chlorophenylthio)-2-methylaminopropane fumarate. USE:Preventive and remedy for obesity and diabetes. It has low toxicity and is free from stimulating action to central vervous system. It can be administered safely for a long period. PROCESS:The compound of formulaIis prepared by reacting the thiophenol derivative of formula II with chloroacetone according to the reaction formula, and subjecting the resultant compound of formula III to the reductive amination reaction with R<3>NH2 using LiBH3CN or NaBH3CN as a reducing agent. The reaction is carried out in a solvent such as methanol, in the presence of 1-3mol of an acid such as HCl, using 2-20mol of R<3>NH2 based on 1mol of the compound of formula III.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56101454A JPS584760A (en) | 1981-06-29 | 1981-06-29 | 1-phenylthio-2-aminopropane derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8201618L true SE8201618L (en) | 1982-12-30 |
Family
ID=14301134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8201618A SE8201618L (en) | 1981-06-29 | 1982-03-15 | 1-PHENYLTIO-2-AMINOPROPANDER DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND THE USE OF THE SAME |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS584760A (en) |
| DK (1) | DK101082A (en) |
| SE (1) | SE8201618L (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0745671B2 (en) * | 1986-01-23 | 1995-05-17 | 三菱重工業株式会社 | Coal slurry manufacturing method |
-
1981
- 1981-06-29 JP JP56101454A patent/JPS584760A/en active Pending
-
1982
- 1982-03-09 DK DK101082A patent/DK101082A/en not_active Application Discontinuation
- 1982-03-15 SE SE8201618A patent/SE8201618L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS584760A (en) | 1983-01-11 |
| DK101082A (en) | 1982-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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