SE8103106L - PROCEDURE FOR THE PREPARATION OF 4A-ARYL-OCTAHYDRO-1H-2-PYRINDINES - Google Patents

PROCEDURE FOR THE PREPARATION OF 4A-ARYL-OCTAHYDRO-1H-2-PYRINDINES

Info

Publication number
SE8103106L
SE8103106L SE8103106A SE8103106A SE8103106L SE 8103106 L SE8103106 L SE 8103106L SE 8103106 A SE8103106 A SE 8103106A SE 8103106 A SE8103106 A SE 8103106A SE 8103106 L SE8103106 L SE 8103106L
Authority
SE
Sweden
Prior art keywords
compound
pyrindines
octahydro
aryl
procedure
Prior art date
Application number
SE8103106A
Other languages
Swedish (sv)
Inventor
D M Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SE8103106L publication Critical patent/SE8103106L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Claims (1)

1. Patentkrav FOrfarande for :Crams-tanning av en cis-forening med den allmNn- na formeln: dar Ri ocn R2 bar de ovan angivna betydelsei7na, omsattes med era reduktionsmedel; vdrefter eventuellt, nNr 02 betecknar C1-03-alkoxi, den erhAllna foreningen avetras till bildLing av en fOrening med formeln I, dal, R2 betecknar hydroxf_. (I) dar IO. betecknar 01-C8-alkyl elder bensyl; och dar R2 betecknar vate, hydroxi eller 01-03-alkoxi; sant ogiftiga, farmaceutiskt godtagbara syraadditionssalter ddrav, kOnnetecknat av att en forening ned den allmanna formeln:A process for: Crams-tanning of a cis compound of the general formula: wherein R 1 and R 2 had the meanings given above, were reacted with your reducing agents; then optionally, when O 2 represents C 1-3 alkoxy, the resulting compound is etherified to give a compound of formula I, dal, R 2 represents hydroxy. (I) dar IO. represents C 1 -C 8 -alkyl or benzyl; and wherein R 2 represents hydrogen, hydroxy or 01-03-alkoxy; true non-toxic, pharmaceutically acceptable acid addition salts ddrav, characterized in that a compound of the general formula:
SE8103106A 1976-11-02 1981-05-18 PROCEDURE FOR THE PREPARATION OF 4A-ARYL-OCTAHYDRO-1H-2-PYRINDINES SE8103106L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
SE8103106L true SE8103106L (en) 1981-05-18

Family

ID=24965981

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7712218A SE7712218L (en) 1976-11-02 1977-10-28 PROCEDURE FOR THE PREPARATION OF 4A-ARYLOCTAHYDRO-1H-2-PYRINDINES
SE8103107A SE8103107L (en) 1976-11-02 1981-05-18 PROCEDURE FOR THE PREPARATION OF 4A-ARYL-OCTAHYDRO-1H-2-PYRINDINES
SE8103106A SE8103106L (en) 1976-11-02 1981-05-18 PROCEDURE FOR THE PREPARATION OF 4A-ARYL-OCTAHYDRO-1H-2-PYRINDINES

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SE7712218A SE7712218L (en) 1976-11-02 1977-10-28 PROCEDURE FOR THE PREPARATION OF 4A-ARYLOCTAHYDRO-1H-2-PYRINDINES
SE8103107A SE8103107L (en) 1976-11-02 1981-05-18 PROCEDURE FOR THE PREPARATION OF 4A-ARYL-OCTAHYDRO-1H-2-PYRINDINES

Country Status (26)

Country Link
JP (1) JPS5356669A (en)
AR (1) AR223454A1 (en)
AT (1) ATA782177A (en)
AU (1) AU513679B2 (en)
BE (1) BE860314A (en)
CA (1) CA1100136A (en)
CS (1) CS211380B2 (en)
DD (1) DD133795A5 (en)
DE (1) DE2748466A1 (en)
DK (1) DK485277A (en)
ES (3) ES463784A1 (en)
FR (1) FR2369267A1 (en)
GB (1) GB1590155A (en)
GR (1) GR70053B (en)
HU (1) HU176231B (en)
IE (1) IE45901B1 (en)
IL (1) IL53236A0 (en)
NL (1) NL7712053A (en)
NZ (1) NZ185539A (en)
PH (1) PH12590A (en)
PL (3) PL108466B1 (en)
PT (1) PT67194B (en)
RO (3) RO77935A (en)
SE (3) SE7712218L (en)
SU (3) SU812174A3 (en)
ZA (1) ZA776497B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189230A (en) * 1977-12-27 1981-05-15 Lilly Co Eli Trans-4a-aryl-2-substituted-octahydro-1h-2-pyrindines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
HUE028983T2 (en) 2010-05-06 2017-01-30 Vertex Pharma Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels
EP3056495A1 (en) 2011-02-02 2016-08-17 Vertex Pharmaceuticals Inc. Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
WO2012125613A1 (en) 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Also Published As

Publication number Publication date
PT67194B (en) 1979-03-23
SE8103107L (en) 1981-05-18
FR2369267B1 (en) 1980-05-16
BE860314A (en) 1978-04-28
DK485277A (en) 1978-05-03
GB1590155A (en) 1981-05-28
ES463783A1 (en) 1979-07-16
NZ185539A (en) 1979-12-11
PL108610B1 (en) 1980-04-30
GR70053B (en) 1982-07-26
PT67194A (en) 1977-11-01
IE45901B1 (en) 1982-12-29
PL201885A1 (en) 1978-12-04
IE45901L (en) 1978-05-02
SU812174A3 (en) 1981-03-07
HU176231B (en) 1981-01-28
CA1100136A (en) 1981-04-28
RO78300A (en) 1982-04-12
AR223454A1 (en) 1981-08-31
NL7712053A (en) 1978-05-05
ES463784A1 (en) 1978-06-16
ATA782177A (en) 1981-10-15
AU513679B2 (en) 1980-12-18
PL109690B1 (en) 1980-06-30
SU845777A3 (en) 1981-07-07
RO77935A (en) 1981-12-25
RO72900A (en) 1981-11-04
ES472276A1 (en) 1979-10-01
DE2748466A1 (en) 1978-05-03
PH12590A (en) 1979-06-27
FR2369267A1 (en) 1978-05-26
SE7712218L (en) 1978-05-03
JPS5356669A (en) 1978-05-23
AU3023577A (en) 1979-05-10
SU913941A3 (en) 1982-03-15
DD133795A5 (en) 1979-01-24
CS211380B2 (en) 1982-02-26
ZA776497B (en) 1979-06-27
IL53236A0 (en) 1977-12-30
PL108466B1 (en) 1980-04-30

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