SE8101703L - NEW ISOXAZOLD DERIVATIVES JUST SET FOR THEIR PREPARATION - Google Patents

NEW ISOXAZOLD DERIVATIVES JUST SET FOR THEIR PREPARATION

Info

Publication number
SE8101703L
SE8101703L SE8101703A SE8101703A SE8101703L SE 8101703 L SE8101703 L SE 8101703L SE 8101703 A SE8101703 A SE 8101703A SE 8101703 A SE8101703 A SE 8101703A SE 8101703 L SE8101703 L SE 8101703L
Authority
SE
Sweden
Prior art keywords
group
alkyl
oxy
stands
amino
Prior art date
Application number
SE8101703A
Other languages
Swedish (sv)
Other versions
SE454695B (en
Inventor
R Bognar
Ferenczik I Pelyvas
F Sztaricskai
Z Gyorgydeak
J Szegi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of SE8101703L publication Critical patent/SE8101703L/en
Publication of SE454695B publication Critical patent/SE454695B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Abstract

Isoxazole derivatives of the general formula (I) and acid addition salts thereof <IMAGE> (wherein R represents a C1-4 alkyl or a phenyl group, R2 denotes a halogen atom or a (C1-4 alkoxy)-carbonyl group, R1 represents a group of the formula -CH(NH2)-COOH, or a guanyl-thio, a bis- C1-4 alkoxycarbonyl-C1-4alkanoyl-amido- methyl, an amino-oxy, a carbamoylamino-oxy, a guanidino- oxy, a phthalimido-oxy group or a group of the general formula -NR3R4, wherein R3 stands for a hydrogen atom or a C1-4 alkyl, C3-6 cycloalkyl, omega -halogen-(C1-4 alkyl), di-(C1-4 alkyl)- amino-(C1-4 alkyl), 2,6- dihalogenbenzyl group or a p-amino- phenyl-sulfonyl group which latter may be N-substituted by a C1-4 alkanoyl group, and R4 stands for a hydrogen atom or a C1-4 alkyl group, or R3 and R4 together represent a 2,6- dihalogen-benzylidene group, or R3 and R4 form, together with the adjacent nitrogen atom a 6 membered heterocyclic ring which may optionally contain an oxygen as a further hetero atom, with the proviso that if R represents methyl and R1 stands for a guanyl-thio group, R2 may represent only chlorine), possess hypotensive, antiinflammatory and antipyretic activity.
SE8101703A 1980-03-19 1981-03-17 NEW ISOXAZOLD DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL COMPOSITION THEREOF SE454695B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU8080637A HU180567B (en) 1980-03-19 1980-03-19 Method for producing derivatives of isooxazole

Publications (2)

Publication Number Publication Date
SE8101703L true SE8101703L (en) 1981-09-20
SE454695B SE454695B (en) 1988-05-24

Family

ID=10950573

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8101703A SE454695B (en) 1980-03-19 1981-03-17 NEW ISOXAZOLD DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL COMPOSITION THEREOF

Country Status (15)

Country Link
JP (1) JPS56158774A (en)
BE (1) BE887954A (en)
CA (1) CA1163631A (en)
CH (1) CH646157A5 (en)
DE (1) DE3110817A1 (en)
DK (3) DK151012C (en)
ES (3) ES8302674A1 (en)
FI (1) FI70011C (en)
FR (1) FR2478634A1 (en)
GB (1) GB2075009B (en)
HU (1) HU180567B (en)
IT (1) IT1211010B (en)
SE (1) SE454695B (en)
SU (3) SU1053750A3 (en)
YU (1) YU42560B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100260A (en) * 1997-04-21 2000-08-08 Sumitomo Pharmaceutical Company, Limited Isoxazole derivatives
CN1138764C (en) * 1997-04-21 2004-02-18 住友制药株式会社 Isoxazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL302496A (en) * 1962-12-22
US3808221A (en) * 1971-04-14 1974-04-30 Hoffmann La Roche Antiandrogenic n-(3,5-dilower alkyl-4-heterocyclic)methyl)phthalimides

Also Published As

Publication number Publication date
ES511895A0 (en) 1983-05-01
DK122581A (en) 1981-09-20
HU180567B (en) 1983-03-28
YU68981A (en) 1983-10-31
IT8120395A0 (en) 1981-03-18
ES8305340A1 (en) 1983-05-01
DK151012B (en) 1987-10-12
DK153549C (en) 1988-12-05
DK23087A (en) 1987-01-16
DK23187A (en) 1987-01-16
YU42560B (en) 1988-10-31
ES8401758A1 (en) 1984-01-01
SU1152518A3 (en) 1985-04-23
FI70011C (en) 1986-09-12
DK151959C (en) 1988-07-11
ES511894A0 (en) 1984-01-01
GB2075009B (en) 1983-11-30
CA1163631A (en) 1984-03-13
DK151959B (en) 1988-01-18
CH646157A5 (en) 1984-11-15
DE3110817A1 (en) 1982-03-04
DK151012C (en) 1988-07-04
ES501095A0 (en) 1983-02-16
SU1053750A3 (en) 1983-11-07
GB2075009A (en) 1981-11-11
FI810838L (en) 1981-09-20
IT1211010B (en) 1989-09-29
DK153549B (en) 1988-07-25
SU1158044A3 (en) 1985-05-23
BE887954A (en) 1981-09-16
FI70011B (en) 1986-01-31
SE454695B (en) 1988-05-24
JPS56158774A (en) 1981-12-07
ES8302674A1 (en) 1983-02-16
FR2478634A1 (en) 1981-09-25
FR2478634B1 (en) 1983-11-10

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