ES8401758A1 - Isoxazoles - Google Patents
IsoxazolesInfo
- Publication number
- ES8401758A1 ES8401758A1 ES511894A ES511894A ES8401758A1 ES 8401758 A1 ES8401758 A1 ES 8401758A1 ES 511894 A ES511894 A ES 511894A ES 511894 A ES511894 A ES 511894A ES 8401758 A1 ES8401758 A1 ES 8401758A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- oxy
- stands
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002545 isoxazoles Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- -1 carbamoylamino-oxy Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
Abstract
Isoxazole derivatives of the general formula (I) and acid addition salts thereof < IMAGE > (wherein R represents a C1-4 alkyl or a phenyl group, R2 denotes a halogen atom or a (C1-4 alkoxy)-carbonyl group, R1 represents a group of the formula -CH(NH2)-COOH, or a guanyl-thio, a bis- C1-4 alkoxycarbonyl-C1-4alkanoyl-amido- methyl, an amino-oxy, a carbamoylamino-oxy, a guanidino- oxy, a phthalimido-oxy group or a group of the general formula -NR3R4, wherein R3 stands for a hydrogen atom or a C1-4 alkyl, C3-6 cycloalkyl, omega -halogen-(C1-4 alkyl), di-(C1-4 alkyl)- amino-(C1-4 alkyl), 2,6- dihalogenbenzyl group or a p-amino- phenyl-sulfonyl group which latter may be N-substituted by a C1-4 alkanoyl group, and R4 stands for a hydrogen atom or a C1-4 alkyl group, or R3 and R4 together represent a 2,6- dihalogen-benzylidene group, or R3 and R4 form, together with the adjacent nitrogen atom a 6 membered heterocyclic ring which may optionally contain an oxygen as a further hetero atom, with the proviso that if R represents methyl and R1 stands for a guanyl-thio group, R2 may represent only chlorine), possess hypotensive, antiinflammatory and antipyretic activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU8080637A HU180567B (en) | 1980-03-19 | 1980-03-19 | Method for producing derivatives of isooxazole |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8401758A1 true ES8401758A1 (en) | 1984-01-01 |
| ES511894A0 ES511894A0 (en) | 1984-01-01 |
Family
ID=10950573
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES501095A Expired ES8302674A1 (en) | 1980-03-19 | 1981-03-18 | Isoxazoles |
| ES511894A Granted ES511894A0 (en) | 1980-03-19 | 1982-04-16 | "METHOD OF PREPARING ISOXAZOL-5-IL-METHYLENEOXYGUANIDINE DERIVATIVES". |
| ES511895A Expired ES8305340A1 (en) | 1980-03-19 | 1982-04-16 | Isoxazoles |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES501095A Expired ES8302674A1 (en) | 1980-03-19 | 1981-03-18 | Isoxazoles |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES511895A Expired ES8305340A1 (en) | 1980-03-19 | 1982-04-16 | Isoxazoles |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS56158774A (en) |
| BE (1) | BE887954A (en) |
| CA (1) | CA1163631A (en) |
| CH (1) | CH646157A5 (en) |
| DE (1) | DE3110817A1 (en) |
| DK (3) | DK151012C (en) |
| ES (3) | ES8302674A1 (en) |
| FI (1) | FI70011C (en) |
| FR (1) | FR2478634A1 (en) |
| GB (1) | GB2075009B (en) |
| HU (1) | HU180567B (en) |
| IT (1) | IT1211010B (en) |
| SE (1) | SE454695B (en) |
| SU (3) | SU1053750A3 (en) |
| YU (1) | YU42560B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0979226B1 (en) * | 1997-04-21 | 2005-11-09 | Sumitomo Pharmaceuticals Company, Limited | Isoxazole derivatives |
| US6100260A (en) * | 1997-04-21 | 2000-08-08 | Sumitomo Pharmaceutical Company, Limited | Isoxazole derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL302496A (en) * | 1962-12-22 | |||
| US3808221A (en) * | 1971-04-14 | 1974-04-30 | Hoffmann La Roche | Antiandrogenic n-(3,5-dilower alkyl-4-heterocyclic)methyl)phthalimides |
-
1980
- 1980-03-19 HU HU8080637A patent/HU180567B/en not_active IP Right Cessation
-
1981
- 1981-03-16 BE BE1/10179A patent/BE887954A/en not_active IP Right Cessation
- 1981-03-17 YU YU689/81A patent/YU42560B/en unknown
- 1981-03-17 SE SE8101703A patent/SE454695B/en not_active IP Right Cessation
- 1981-03-18 GB GB8108545A patent/GB2075009B/en not_active Expired
- 1981-03-18 DK DK122581A patent/DK151012C/en not_active IP Right Cessation
- 1981-03-18 FI FI810838A patent/FI70011C/en not_active IP Right Cessation
- 1981-03-18 CH CH182981A patent/CH646157A5/en not_active IP Right Cessation
- 1981-03-18 ES ES501095A patent/ES8302674A1/en not_active Expired
- 1981-03-18 IT IT8120395A patent/IT1211010B/en active
- 1981-03-18 FR FR8105378A patent/FR2478634A1/en active Granted
- 1981-03-19 DE DE19813110817 patent/DE3110817A1/en not_active Withdrawn
- 1981-03-19 CA CA000373380A patent/CA1163631A/en not_active Expired
- 1981-03-19 JP JP4023281A patent/JPS56158774A/en active Pending
- 1981-03-19 SU SU813261940A patent/SU1053750A3/en active
-
1982
- 1982-04-01 SU SU823416146A patent/SU1158044A3/en active
- 1982-04-01 SU SU823414099A patent/SU1152518A3/en active
- 1982-04-16 ES ES511894A patent/ES511894A0/en active Granted
- 1982-04-16 ES ES511895A patent/ES8305340A1/en not_active Expired
-
1987
- 1987-01-16 DK DK023187A patent/DK153549C/en not_active IP Right Cessation
- 1987-01-16 DK DK023087A patent/DK151959C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB2075009A (en) | 1981-11-11 |
| DK151012C (en) | 1988-07-04 |
| IT8120395A0 (en) | 1981-03-18 |
| DK151959B (en) | 1988-01-18 |
| YU42560B (en) | 1988-10-31 |
| DE3110817A1 (en) | 1982-03-04 |
| FR2478634A1 (en) | 1981-09-25 |
| IT1211010B (en) | 1989-09-29 |
| BE887954A (en) | 1981-09-16 |
| ES501095A0 (en) | 1983-02-16 |
| SU1158044A3 (en) | 1985-05-23 |
| CA1163631A (en) | 1984-03-13 |
| DK151959C (en) | 1988-07-11 |
| SU1152518A3 (en) | 1985-04-23 |
| GB2075009B (en) | 1983-11-30 |
| DK151012B (en) | 1987-10-12 |
| FI70011C (en) | 1986-09-12 |
| ES511895A0 (en) | 1983-05-01 |
| DK122581A (en) | 1981-09-20 |
| JPS56158774A (en) | 1981-12-07 |
| ES8302674A1 (en) | 1983-02-16 |
| SE454695B (en) | 1988-05-24 |
| SU1053750A3 (en) | 1983-11-07 |
| FR2478634B1 (en) | 1983-11-10 |
| HU180567B (en) | 1983-03-28 |
| SE8101703L (en) | 1981-09-20 |
| FI70011B (en) | 1986-01-31 |
| CH646157A5 (en) | 1984-11-15 |
| DK23087A (en) | 1987-01-16 |
| FI810838L (en) | 1981-09-20 |
| DK153549B (en) | 1988-07-25 |
| DK23187A (en) | 1987-01-16 |
| DK153549C (en) | 1988-12-05 |
| ES511894A0 (en) | 1984-01-01 |
| YU68981A (en) | 1983-10-31 |
| ES8305340A1 (en) | 1983-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990201 |