SE8003242L - NEW STEROID-5ALFA REDUCTASE INHIBITORS - Google Patents
NEW STEROID-5ALFA REDUCTASE INHIBITORSInfo
- Publication number
- SE8003242L SE8003242L SE8003242A SE8003242A SE8003242L SE 8003242 L SE8003242 L SE 8003242L SE 8003242 A SE8003242 A SE 8003242A SE 8003242 A SE8003242 A SE 8003242A SE 8003242 L SE8003242 L SE 8003242L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- 5alfa
- reductase inhibitors
- coo
- cooh
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The title compounds are of formula <IMAGE> wherein R is =O, -OH, -OCO(C1-5 alkyl), -COOH, -CH2OH, -CHO, -COO(C1-6 alkyl), -COCH3, -CH(CH3)-COOH, -CH(CH3)- COO(C1-6 alkyl), beta -O-(CH2)3- alpha or a 20 beta -isomer of -CH(CH3-)- CH2OH, CH(CH3)-CHO, -CH(CH3)-COOH or -CH(CH3)- COO(C1-6 alkyl). These compounds have utility as inhibitors of the enzyme which converts testosterone to dihydrotestosterone, and may be made up into pharmaceutical compositions for treating acne and oily skin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3535779A | 1979-05-02 | 1979-05-02 | |
US6974179A | 1979-08-27 | 1979-08-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8003242L true SE8003242L (en) | 1980-11-03 |
SE448097B SE448097B (en) | 1987-01-19 |
Family
ID=26712031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8003242A SE448097B (en) | 1979-05-02 | 1980-04-29 | NEW STEROID-5ALFA REDUCED INHIBITORS, PHARMACEUTICAL COMPOSITION CONTAINING THESE AND PROCEDURES FOR PRODUCING THESE |
Country Status (16)
Country | Link |
---|---|
AT (1) | AT390794B (en) |
AU (1) | AU532558B2 (en) |
CA (1) | CA1154008A (en) |
CH (1) | CH643863A5 (en) |
DE (1) | DE3017015A1 (en) |
DK (1) | DK166501B1 (en) |
ES (1) | ES8105012A1 (en) |
FR (1) | FR2455610A1 (en) |
GB (1) | GB2048888B (en) |
IE (1) | IE49704B1 (en) |
IL (1) | IL59934A (en) |
IT (1) | IT1188932B (en) |
NL (1) | NL191387C (en) |
NO (1) | NO154884C (en) |
NZ (1) | NZ193527A (en) |
SE (1) | SE448097B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8503940D0 (en) * | 1985-02-15 | 1985-03-20 | Erba Farmitalia | 4-substituted androstendione derivatives |
NZ239142A (en) * | 1990-08-01 | 1994-05-26 | Merrell Dow Pharma | 4-amino-delta-4-steroids; preparatory processes and pharmaceutical compositions |
US5143909A (en) * | 1991-03-19 | 1992-09-01 | Merrell Dow Pharmaceuticals Inc. | Aminosteroids in a method for inhibiting c17-20 lyase |
AU642757B2 (en) * | 1990-08-01 | 1993-10-28 | Merrell Dow Pharmaceuticals Inc. | 4-amino-delta4, 6-steroids and their use as 5alpha-reductase inhibitors |
EP0794456B1 (en) | 1996-03-07 | 2003-01-29 | Agfa-Gevaert | Method of reproducing an electronically stored medical image on a light-sensitive photographic material |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3917829A (en) * | 1971-11-08 | 1975-11-04 | Research Corp | Novel methods of inhibiting the activity of testosterone 5{60 -reductase |
US4088760A (en) * | 1976-06-23 | 1978-05-09 | Richardson-Merrell Inc. | Testosterone 5α-reductase inhibitors |
-
1980
- 1980-04-21 CA CA000350283A patent/CA1154008A/en not_active Expired
- 1980-04-22 IE IE806/80A patent/IE49704B1/en not_active IP Right Cessation
- 1980-04-23 AU AU57747/80A patent/AU532558B2/en not_active Expired
- 1980-04-24 NZ NZ193527A patent/NZ193527A/en unknown
- 1980-04-25 GB GB8013775A patent/GB2048888B/en not_active Expired
- 1980-04-28 IL IL59934A patent/IL59934A/en unknown
- 1980-04-29 SE SE8003242A patent/SE448097B/en not_active IP Right Cessation
- 1980-04-29 ES ES491010A patent/ES8105012A1/en not_active Expired
- 1980-04-30 NO NO801254A patent/NO154884C/en unknown
- 1980-04-30 IT IT48559/80A patent/IT1188932B/en active
- 1980-04-30 CH CH335980A patent/CH643863A5/en not_active IP Right Cessation
- 1980-04-30 AT AT0232880A patent/AT390794B/en not_active IP Right Cessation
- 1980-04-30 FR FR8009848A patent/FR2455610A1/en active Granted
- 1980-05-01 NL NL8002529A patent/NL191387C/en not_active IP Right Cessation
- 1980-05-01 DK DK194180A patent/DK166501B1/en not_active IP Right Cessation
- 1980-05-02 DE DE19803017015 patent/DE3017015A1/en active Granted
Also Published As
Publication number | Publication date |
---|---|
NL191387B (en) | 1995-02-01 |
NO154884C (en) | 1987-01-07 |
SE448097B (en) | 1987-01-19 |
AT390794B (en) | 1990-06-25 |
IE49704B1 (en) | 1985-11-27 |
DE3017015A1 (en) | 1980-11-20 |
DK166501B1 (en) | 1993-06-01 |
NO801254L (en) | 1980-11-03 |
FR2455610A1 (en) | 1980-11-28 |
NO154884B (en) | 1986-09-29 |
ES491010A0 (en) | 1981-05-16 |
DK194180A (en) | 1980-11-03 |
AU5774780A (en) | 1980-11-06 |
ATA232880A (en) | 1989-12-15 |
IT1188932B (en) | 1988-01-28 |
NL8002529A (en) | 1980-11-04 |
AU532558B2 (en) | 1983-10-06 |
NZ193527A (en) | 1984-10-19 |
ES8105012A1 (en) | 1981-05-16 |
FR2455610B1 (en) | 1982-04-30 |
CA1154008A (en) | 1983-09-20 |
CH643863A5 (en) | 1984-06-29 |
DE3017015C2 (en) | 1989-04-20 |
IT8048559A1 (en) | 1981-10-30 |
IL59934A0 (en) | 1980-06-30 |
NL191387C (en) | 1995-07-03 |
IE800806L (en) | 1980-11-02 |
GB2048888B (en) | 1983-05-25 |
GB2048888A (en) | 1980-12-17 |
IT8048559A0 (en) | 1980-04-30 |
IL59934A (en) | 1983-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK436182A (en) | CYCLOVITAMIN-D COMPOUNDS | |
MX6180E (en) | AN IMPROVED PROCEDURE FOR OBTAINING AN ALPHA-MONKEY- (METHYL-BRANCHED ALKYL) -GLYCERYLLIC | |
JPS5559140A (en) | 3,5-dihydroxypentanoic alkyl ester derivative, its preparation and remedy for hyperlipemia containing the same as the effective component | |
FI792259A (en) | FOERFARANDE FOER KONTROLL AV FAESTINGAR PAO VARMBLODIGA DJUR GENOM ATT ORALT TILLFOERA DJURET EN FAESTINGSEFFEKTIV MAENGD AV EN 2-ARYL-1,3-CYCLOHEXAN FOERENING SAMT ALKALISKA METALLSALTER OMERIUMS | |
SE8002292L (en) | 4-AMINO-3-QUINOLINKARBOXYLIC ACIDS AND ESTERS AS ANTI-SECRETORIC ANTI-ULCEROUS COMPOUNDS | |
DE3062452D1 (en) | Branched fatty acid cholesterol ester and a cosmetic composition containing the same | |
SE7601143L (en) | NEW OXADIAZOLINE DERIVATIVE | |
SE8003242L (en) | NEW STEROID-5ALFA REDUCTASE INHIBITORS | |
NZ234410A (en) | 3-methoximinopropionic ester derivatives and fungicidal compositions | |
FR2496638B1 (en) | ||
ES2071713T3 (en) | N-HETEROCICLOMETIL-SPIROHETEROCICLOS AND THE FUNGICIDES THAT CONTAIN THEM. | |
JPS5695193A (en) | Silyllbenzimidazolee22carbamic acid ester* its manufacture and fungicide containing it as effective substance | |
JPS5579395A (en) | Novel germanium compound | |
JPS5210218A (en) | Preparation of beta-sulfenylacrylamides | |
BR8100315A (en) | PROCESS FOR THE PREPARATION OF INDAN-4-ILO ESTERS OF N-ALKYL-CARBAMIC ACIDS, FUNGICID COMPOSITES, PROCESS FOR COMBATING FUNGI AND PROCESS TO PREPARE FUNGICID COMPOSITES | |
ES502947A0 (en) | PROCEDURE FOR THE OBTAINING OF ESTERS OF DIMETH ACID-CRYLIC | |
JPS5692279A (en) | Thiazolidine derivative | |
JPS5432457A (en) | Preparation of 2-alkyl-3-hydroxycyclo-pentylacetic acid esters and perfume composition containing the same | |
JPS52133959A (en) | 2-cyano-3-methyl-3-(naphthyl)acrylic acids and method of preparing the same | |
JPS53112870A (en) | 3-methyl-3-(4-(1-oxo-2-isoindolinyl)phenyl)glycidic acid, its salt and ester and their preparation | |
GB1004661A (en) | D-(+)-2-(6-alkoxy-3-indolyl)-propylamines | |
JPS52236A (en) | Process for preparation of alpha-substituted benzylphenylether derivatives | |
GB2006765A (en) | Tricyclic purine derivatives, their preparation and pharmaceutical compositions containing them | |
JPS5750983A (en) | Benzoquinone derivative and its preparation | |
GB2013676A (en) | beta -Lactam compounds derived from clavulanic acid, preparation and use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NAL | Patent in force |
Ref document number: 8003242-8 Format of ref document f/p: F |
|
NUG | Patent has lapsed |
Ref document number: 8003242-8 Format of ref document f/p: F |