SE7904080L - TERMINAL-BIFUNCTIONAL XYLITE DERIVATIVES - Google Patents

TERMINAL-BIFUNCTIONAL XYLITE DERIVATIVES

Info

Publication number
SE7904080L
SE7904080L SE7904080A SE7904080A SE7904080L SE 7904080 L SE7904080 L SE 7904080L SE 7904080 A SE7904080 A SE 7904080A SE 7904080 A SE7904080 A SE 7904080A SE 7904080 L SE7904080 L SE 7904080L
Authority
SE
Sweden
Prior art keywords
derivatives
xylite
bifunctional
terminal
xylitol
Prior art date
Application number
SE7904080A
Other languages
Swedish (sv)
Inventor
I Vidra
L Institoris
S Eckhardt
K Lapis
A Jeney
L Kopper
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of SE7904080L publication Critical patent/SE7904080L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/64—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by simultaneous introduction of -OH groups and halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/42—Polyhydroxylic acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

Xylitol derivatives of the general formula <IMAGE> wherein R<1> and R<5> are the same and represent halogen, tosyloxy or mesyloxy, in which case R<2> and R<4> represent hydroxy or R<1> and R<2> as well as R<4> and R<5> together form oxygen bridges, R<3>, whatever the values of R<1>, R<2>, R<4> and R<5>, is hydrogen, alkanoyl, aralkanoyl or aroyl, exhibit cytostatic activity. They can be prepared from xylitol by standard methods. The compounds can be formulated for pharmaceutical use in conventional manner.
SE7904080A 1978-05-11 1979-05-09 TERMINAL-BIFUNCTIONAL XYLITE DERIVATIVES SE7904080L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78CI1826A HU176216B (en) 1978-05-11 1978-05-11 Process for producing terminally bifuntional xylite derivatives of citostatic activity

Publications (1)

Publication Number Publication Date
SE7904080L true SE7904080L (en) 1979-11-12

Family

ID=10994695

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7904080A SE7904080L (en) 1978-05-11 1979-05-09 TERMINAL-BIFUNCTIONAL XYLITE DERIVATIVES

Country Status (26)

Country Link
JP (1) JPS5522662A (en)
AR (1) AR222332A1 (en)
AT (1) AT361945B (en)
BE (1) BE876166A (en)
CA (1) CA1145349A (en)
CH (1) CH641437A5 (en)
CS (1) CS211399B2 (en)
DD (1) DD143765A5 (en)
DE (1) DE2917538A1 (en)
DK (1) DK195279A (en)
EG (1) EG15150A (en)
ES (1) ES480869A1 (en)
FI (1) FI67845C (en)
FR (1) FR2425445A1 (en)
GB (1) GB2024204B (en)
GR (1) GR68495B (en)
HU (1) HU176216B (en)
IL (1) IL57182A (en)
IN (1) IN150040B (en)
IT (1) IT1118485B (en)
NL (1) NL7903634A (en)
NO (1) NO153928C (en)
PL (1) PL121560B1 (en)
SE (1) SE7904080L (en)
SU (1) SU984410A3 (en)
YU (1) YU108079A (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH381666A (en) * 1958-04-24 1964-09-15 Nat Res Dev Process for the preparation of derivatives of polyhydric alcohols
DE1668241A1 (en) * 1968-03-06 1971-02-11 Herbrand Kg Dr Therapeutically effective 1,5-di-substituted derivatives of xylitol, adonitol and arabitol

Also Published As

Publication number Publication date
CH641437A5 (en) 1984-02-29
DD143765A5 (en) 1980-09-10
FR2425445B1 (en) 1984-06-08
FI791484A (en) 1979-11-12
CA1145349A (en) 1983-04-26
DE2917538A1 (en) 1979-11-15
IL57182A (en) 1983-07-31
HU176216B (en) 1981-01-28
DK195279A (en) 1979-11-12
IT1118485B (en) 1986-03-03
ATA347779A (en) 1980-09-15
NO153928C (en) 1986-06-18
AT361945B (en) 1981-04-10
PL215489A1 (en) 1980-02-11
FI67845B (en) 1985-02-28
IN150040B (en) 1982-07-03
GR68495B (en) 1982-01-07
PL121560B1 (en) 1982-05-31
CS211399B2 (en) 1982-02-26
IT7967984A0 (en) 1979-05-10
NO153928B (en) 1986-03-10
SU984410A3 (en) 1982-12-23
FR2425445A1 (en) 1979-12-07
ES480869A1 (en) 1980-06-16
EG15150A (en) 1985-12-31
NL7903634A (en) 1979-11-13
IL57182A0 (en) 1979-07-25
YU108079A (en) 1982-10-31
BE876166A (en) 1979-09-03
NO791564L (en) 1979-11-13
JPS5522662A (en) 1980-02-18
GB2024204A (en) 1980-01-09
FI67845C (en) 1985-06-10
GB2024204B (en) 1982-10-27
AR222332A1 (en) 1981-05-15

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