ES480869A1 - Xylitol derivatives, their preparation and pharmaceutical compositions containing them - Google Patents

Xylitol derivatives, their preparation and pharmaceutical compositions containing them

Info

Publication number
ES480869A1
ES480869A1 ES480869A ES480869A ES480869A1 ES 480869 A1 ES480869 A1 ES 480869A1 ES 480869 A ES480869 A ES 480869A ES 480869 A ES480869 A ES 480869A ES 480869 A1 ES480869 A1 ES 480869A1
Authority
ES
Spain
Prior art keywords
xylitol
preparation
pharmaceutical compositions
compositions containing
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES480869A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of ES480869A1 publication Critical patent/ES480869A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/64—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by simultaneous introduction of -OH groups and halogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/42—Polyhydroxylic acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

Xylitol derivatives of the general formula < IMAGE > wherein R<1> and R<5> are the same and represent halogen, tosyloxy or mesyloxy, in which case R<2> and R<4> represent hydroxy or R<1> and R<2> as well as R<4> and R<5> together form oxygen bridges, R<3>, whatever the values of R<1>, R<2>, R<4> and R<5>, is hydrogen, alkanoyl, aralkanoyl or aroyl, exhibit cytostatic activity. They can be prepared from xylitol by standard methods. The compounds can be formulated for pharmaceutical use in conventional manner.
ES480869A 1978-05-11 1979-05-11 Xylitol derivatives, their preparation and pharmaceutical compositions containing them Expired ES480869A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78CI1826A HU176216B (en) 1978-05-11 1978-05-11 Process for producing terminally bifuntional xylite derivatives of citostatic activity

Publications (1)

Publication Number Publication Date
ES480869A1 true ES480869A1 (en) 1980-06-16

Family

ID=10994695

Family Applications (1)

Application Number Title Priority Date Filing Date
ES480869A Expired ES480869A1 (en) 1978-05-11 1979-05-11 Xylitol derivatives, their preparation and pharmaceutical compositions containing them

Country Status (26)

Country Link
JP (1) JPS5522662A (en)
AR (1) AR222332A1 (en)
AT (1) AT361945B (en)
BE (1) BE876166A (en)
CA (1) CA1145349A (en)
CH (1) CH641437A5 (en)
CS (1) CS211399B2 (en)
DD (1) DD143765A5 (en)
DE (1) DE2917538A1 (en)
DK (1) DK195279A (en)
EG (1) EG15150A (en)
ES (1) ES480869A1 (en)
FI (1) FI67845C (en)
FR (1) FR2425445A1 (en)
GB (1) GB2024204B (en)
GR (1) GR68495B (en)
HU (1) HU176216B (en)
IL (1) IL57182A (en)
IN (1) IN150040B (en)
IT (1) IT1118485B (en)
NL (1) NL7903634A (en)
NO (1) NO153928C (en)
PL (1) PL121560B1 (en)
SE (1) SE7904080L (en)
SU (1) SU984410A3 (en)
YU (1) YU108079A (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH381666A (en) * 1958-04-24 1964-09-15 Nat Res Dev Process for the preparation of derivatives of polyhydric alcohols
DE1668241A1 (en) * 1968-03-06 1971-02-11 Herbrand Kg Dr Therapeutically effective 1,5-di-substituted derivatives of xylitol, adonitol and arabitol

Also Published As

Publication number Publication date
FR2425445B1 (en) 1984-06-08
IT1118485B (en) 1986-03-03
FI67845C (en) 1985-06-10
JPS5522662A (en) 1980-02-18
BE876166A (en) 1979-09-03
NL7903634A (en) 1979-11-13
GB2024204A (en) 1980-01-09
HU176216B (en) 1981-01-28
IN150040B (en) 1982-07-03
AT361945B (en) 1981-04-10
NO153928B (en) 1986-03-10
SE7904080L (en) 1979-11-12
GR68495B (en) 1982-01-07
FI791484A (en) 1979-11-12
FI67845B (en) 1985-02-28
DK195279A (en) 1979-11-12
DD143765A5 (en) 1980-09-10
AR222332A1 (en) 1981-05-15
EG15150A (en) 1985-12-31
DE2917538A1 (en) 1979-11-15
IT7967984A0 (en) 1979-05-10
CH641437A5 (en) 1984-02-29
CA1145349A (en) 1983-04-26
ATA347779A (en) 1980-09-15
GB2024204B (en) 1982-10-27
SU984410A3 (en) 1982-12-23
NO153928C (en) 1986-06-18
PL121560B1 (en) 1982-05-31
NO791564L (en) 1979-11-13
PL215489A1 (en) 1980-02-11
YU108079A (en) 1982-10-31
FR2425445A1 (en) 1979-12-07
IL57182A0 (en) 1979-07-25
IL57182A (en) 1983-07-31
CS211399B2 (en) 1982-02-26

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