SE7811478L - SUBSTITUTED TIOPHENES - Google Patents

SUBSTITUTED TIOPHENES

Info

Publication number
SE7811478L
SE7811478L SE7811478A SE7811478A SE7811478L SE 7811478 L SE7811478 L SE 7811478L SE 7811478 A SE7811478 A SE 7811478A SE 7811478 A SE7811478 A SE 7811478A SE 7811478 L SE7811478 L SE 7811478L
Authority
SE
Sweden
Prior art keywords
denotes
tiophenes
substituted
hydrogen
compounds
Prior art date
Application number
SE7811478A
Other languages
Swedish (sv)
Other versions
SE442509B (en
Inventor
G G I Moore
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of SE7811478L publication Critical patent/SE7811478L/en
Publication of SE442509B publication Critical patent/SE442509B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compounds of formula: <IMAGE> in which L denotes a carbonyl group, or a C/C bond, and R denotes a hydrogen or halogen atom, or a methyl group, have antiinflammatory, and in some cases also analgesic, antipyretic and/or immunosuppressive, properties; they are particularly suitable for use as antiinflammatory agents, as well as oxidation stabilisers. Compounds are preferred in which L denotes a carbonyl group and R denotes a hydrogen or chlorine atom.
SE7811478A 1977-05-16 1978-11-07 2,6-BIS (TERT.-BUTYL) -4- (TENOYL-RESPECTIVE TIENYL -) - PHENOLES WITH ANTI-INFLAMMATORY EFFECTS SE442509B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79718277A 1977-05-16 1977-05-16

Publications (2)

Publication Number Publication Date
SE7811478L true SE7811478L (en) 1980-05-08
SE442509B SE442509B (en) 1986-01-13

Family

ID=25170140

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7811478A SE442509B (en) 1977-05-16 1978-11-07 2,6-BIS (TERT.-BUTYL) -4- (TENOYL-RESPECTIVE TIENYL -) - PHENOLES WITH ANTI-INFLAMMATORY EFFECTS

Country Status (13)

Country Link
JP (1) JPS53141265A (en)
AT (1) AT361467B (en)
AU (1) AU518109B2 (en)
BE (1) BE867067A (en)
CA (1) CA1113103A (en)
CH (1) CH637129A5 (en)
DE (1) DE2821391A1 (en)
FR (1) FR2391208A1 (en)
GB (1) GB1600704A (en)
HK (1) HK11682A (en)
NL (1) NL7805226A (en)
SE (1) SE442509B (en)
ZA (1) ZA782765B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254259A3 (en) * 1986-07-21 1989-11-23 Otsuka Pharmaceutical Factory, Inc. P-aminophenol derivatives
DE10248479A1 (en) * 2002-10-17 2004-05-06 Consortium für elektrochemische Industrie GmbH Preparation of 3-halo-1-thienyl-1-propanone, useful as intermediate for duloxetin an inhibitor of neurotransmitter uptake, by Friedel-Crafts reaction of thiophene and halopropionyl chloride
JP7321777B2 (en) * 2018-05-31 2023-08-07 株式会社トクヤマ Method for producing diaryl ketone compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4017632A (en) * 1975-10-22 1977-04-12 Centre European De Recherches Pharmacologiques C.E.R.P.H.A. Phenoxyacetic acid derivatives

Also Published As

Publication number Publication date
ZA782765B (en) 1979-05-30
AT361467B (en) 1981-03-10
SE442509B (en) 1986-01-13
BE867067A (en) 1978-11-13
DE2821391C2 (en) 1987-03-05
AU518109B2 (en) 1981-09-17
FR2391208A1 (en) 1978-12-15
GB1600704A (en) 1981-10-21
NL7805226A (en) 1978-11-20
FR2391208B1 (en) 1981-02-27
ATA783578A (en) 1980-08-15
HK11682A (en) 1982-03-11
DE2821391A1 (en) 1978-11-30
AU3612978A (en) 1979-11-22
CH637129A5 (en) 1983-07-15
JPS6113715B2 (en) 1986-04-15
CA1113103A (en) 1981-11-24
JPS53141265A (en) 1978-12-08

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