SE7901510L - HALOGEN-SUBSTITUTED MARKAPTOACYLAMINO ACIDS - Google Patents
HALOGEN-SUBSTITUTED MARKAPTOACYLAMINO ACIDSInfo
- Publication number
- SE7901510L SE7901510L SE7901510A SE7901510A SE7901510L SE 7901510 L SE7901510 L SE 7901510L SE 7901510 A SE7901510 A SE 7901510A SE 7901510 A SE7901510 A SE 7901510A SE 7901510 L SE7901510 L SE 7901510L
- Authority
- SE
- Sweden
- Prior art keywords
- halogen
- hydrogen
- markaptoacylamino
- acids
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Abstract
Compounds which have the general formula (I> <IMAGE> wherein R is hydrogen, lower alkanoyl or <IMAGE> m is 1 or 2; n is 0 or 1; R1 is hydrogen or lower alkyl; R2 and R'2 each is hydrogen or halogen; R3 is hydrogen, lower alkyl or CF3, and also halogen when n is 1; R4 is hydrogen, lower alkyl or trifluoromethyl; R6 is hydrogen, and also halogen when m is 1; at least one of R2, R'2, R3, R4 and R6 being halogen or CF3 as represented by the symbols and only R2 and R'2 can both be halogen at the same time, and basic salts thereof may be used as hypotensive agents.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87903278A | 1978-02-21 | 1978-02-21 | |
| US93914878A | 1978-09-01 | 1978-09-01 | |
| US05/939,147 US4154935A (en) | 1978-02-21 | 1978-09-01 | Halogen substituted mercaptoacylamino acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7901510L true SE7901510L (en) | 1979-08-22 |
| SE431643B SE431643B (en) | 1984-02-20 |
Family
ID=27420501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7901510A SE431643B (en) | 1978-02-21 | 1979-02-20 | THERAPEUTICALLY ACTIVE HALOGEN-SUBSTITUTED PROLINE DERIVATIVES CONTAINING SULFUR AND PROCEDURE FOR THEIR PRODUCTION |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS54125656A (en) |
| AR (2) | AR229152A1 (en) |
| CA (1) | CA1124723A (en) |
| CH (1) | CH639370A5 (en) |
| CS (1) | CS230562B2 (en) |
| DD (1) | DD141827A5 (en) |
| DE (1) | DE2906768A1 (en) |
| DK (1) | DK73379A (en) |
| ES (3) | ES477878A1 (en) |
| FI (1) | FI790593A (en) |
| FR (1) | FR2417499A1 (en) |
| GB (1) | GB2014987B (en) |
| GR (1) | GR82336B (en) |
| HK (1) | HK41383A (en) |
| IE (1) | IE47971B1 (en) |
| IL (1) | IL56662A0 (en) |
| LU (1) | LU80946A1 (en) |
| NL (1) | NL7901319A (en) |
| NO (1) | NO790568L (en) |
| NZ (1) | NZ189626A (en) |
| PH (1) | PH15381A (en) |
| PL (1) | PL118158B1 (en) |
| PT (1) | PT69254A (en) |
| RO (1) | RO77228A (en) |
| SE (1) | SE431643B (en) |
| SU (1) | SU882409A3 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
| NL7809120A (en) * | 1978-09-07 | 1980-03-11 | Oce Andeno B V Grubbenvorsterw | PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES. |
| US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
| CA1132985A (en) * | 1978-12-22 | 1982-10-05 | John Krapcho | Ketal and thioketal derivatives of mercaptoacyl prolines |
| ZA802420B (en) * | 1979-05-18 | 1981-04-29 | Squibb & Sons Inc | Aminoacyl derivatives of mercaptoacyl amino acids |
| US4288368A (en) * | 1979-07-30 | 1981-09-08 | E. R. Squibb & Sons, Inc. | Dithioacylproline derivatives |
| AU542211B2 (en) * | 1980-03-07 | 1985-02-14 | Gruppo Lepetit S.P.A. | Mercaptocycloalkyl carbonyl prolines |
| JP2005213165A (en) * | 2004-01-28 | 2005-08-11 | Mitsui Chemicals Inc | Method for producing fluoroproline compounds |
| JP2011121872A (en) * | 2009-12-08 | 2011-06-23 | Central Glass Co Ltd | Method for purifying optically active n-tert-butoxycarbonyl-trans-4-fluoroproline |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
-
1970
- 1970-02-15 PH PH22197A patent/PH15381A/en unknown
-
1979
- 1979-02-08 CA CA321,233A patent/CA1124723A/en not_active Expired
- 1979-02-12 NZ NZ189626A patent/NZ189626A/en unknown
- 1979-02-13 GR GR58343A patent/GR82336B/el unknown
- 1979-02-14 IL IL56662A patent/IL56662A0/en not_active IP Right Cessation
- 1979-02-15 IE IE297/79A patent/IE47971B1/en not_active IP Right Cessation
- 1979-02-19 GB GB7905788A patent/GB2014987B/en not_active Expired
- 1979-02-20 CS CS791134A patent/CS230562B2/en unknown
- 1979-02-20 LU LU80946A patent/LU80946A1/en unknown
- 1979-02-20 AR AR275559A patent/AR229152A1/en active
- 1979-02-20 DK DK73379A patent/DK73379A/en unknown
- 1979-02-20 NL NL7901319A patent/NL7901319A/en not_active Application Discontinuation
- 1979-02-20 ES ES477878A patent/ES477878A1/en not_active Expired
- 1979-02-20 SE SE7901510A patent/SE431643B/en not_active IP Right Cessation
- 1979-02-20 PT PT69254A patent/PT69254A/en unknown
- 1979-02-20 NO NO790568A patent/NO790568L/en unknown
- 1979-02-21 FR FR7904455A patent/FR2417499A1/en active Granted
- 1979-02-21 JP JP2019979A patent/JPS54125656A/en active Granted
- 1979-02-21 DD DD79211155A patent/DD141827A5/en unknown
- 1979-02-21 DE DE19792906768 patent/DE2906768A1/en not_active Ceased
- 1979-02-21 PL PL1979213593A patent/PL118158B1/en unknown
- 1979-02-21 FI FI790593A patent/FI790593A/en unknown
- 1979-02-21 RO RO7996682A patent/RO77228A/en unknown
- 1979-02-21 CH CH168679A patent/CH639370A5/en not_active IP Right Cessation
- 1979-04-23 ES ES479832A patent/ES479832A1/en not_active Expired
- 1979-04-23 ES ES479833A patent/ES479833A1/en not_active Expired
-
1980
- 1980-02-04 SU SU802878653A patent/SU882409A3/en active
- 1980-06-23 AR AR281499A patent/AR228036A1/en active
-
1983
- 1983-10-13 HK HK413/83A patent/HK41383A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU882409A3 (en) | 1981-11-15 |
| ES479833A1 (en) | 1979-11-16 |
| LU80946A1 (en) | 1979-06-18 |
| AR229152A1 (en) | 1983-06-30 |
| DD141827A5 (en) | 1980-05-21 |
| JPH0134986B2 (en) | 1989-07-21 |
| CA1124723A (en) | 1982-06-01 |
| PH15381A (en) | 1982-12-17 |
| NL7901319A (en) | 1979-08-23 |
| RO77228A (en) | 1981-08-17 |
| DK73379A (en) | 1979-08-22 |
| CH639370A5 (en) | 1983-11-15 |
| AR228036A1 (en) | 1983-01-14 |
| HK41383A (en) | 1983-10-21 |
| ES479832A1 (en) | 1979-11-16 |
| GB2014987A (en) | 1979-09-05 |
| PL213593A1 (en) | 1980-02-25 |
| JPS54125656A (en) | 1979-09-29 |
| FR2417499A1 (en) | 1979-09-14 |
| GR82336B (en) | 1984-12-13 |
| NZ189626A (en) | 1982-03-09 |
| NO790568L (en) | 1979-08-22 |
| IE790297L (en) | 1979-08-21 |
| GB2014987B (en) | 1982-11-03 |
| CS230562B2 (en) | 1984-08-13 |
| SE431643B (en) | 1984-02-20 |
| PT69254A (en) | 1979-03-01 |
| PL118158B1 (en) | 1981-09-30 |
| IE47971B1 (en) | 1984-08-08 |
| FI790593A (en) | 1979-08-22 |
| FR2417499B1 (en) | 1982-06-04 |
| DE2906768A1 (en) | 1979-08-23 |
| IL56662A0 (en) | 1979-05-31 |
| ES477878A1 (en) | 1980-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7901510-3 Effective date: 19930912 Format of ref document f/p: F |