SE7612554L - AMINO ALCOHOL DERIVATIVES, AND PROCEDURES FOR MANUFACTURE OF SADANA - Google Patents

AMINO ALCOHOL DERIVATIVES, AND PROCEDURES FOR MANUFACTURE OF SADANA

Info

Publication number
SE7612554L
SE7612554L SE7612554A SE7612554A SE7612554L SE 7612554 L SE7612554 L SE 7612554L SE 7612554 A SE7612554 A SE 7612554A SE 7612554 A SE7612554 A SE 7612554A SE 7612554 L SE7612554 L SE 7612554L
Authority
SE
Sweden
Prior art keywords
activity
image
sadana
procedures
manufacture
Prior art date
Application number
SE7612554A
Other languages
Swedish (sv)
Other versions
SE434744B (en
Inventor
G Lambelin
C Gillet
J Roba
R Roncucci
Original Assignee
Continental Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma filed Critical Continental Pharma
Publication of SE7612554L publication Critical patent/SE7612554L/en
Publication of SE434744B publication Critical patent/SE434744B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/08—Six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Aminoalcohol derivatives corresponding to the formula (I) <IMAGE> in which Q is a group <IMAGE> and the other substituents have the meaning shown in Claim 1 are prepared by reaction with a compound of formula I, in which Q represents a group <IMAGE> or <IMAGE>, with an amine of type R3R4NH, Z being a halogen. The alcohol can then be esterified by reaction with an acid or an anhydride as defined in Claim 1. The compounds obtained have activities on the cardiovascular system, for example antihypertensive and/or antispasmodic activities, peripheral vasodilative activity, protective activity against myocardial anoxia, hypolipidemiating activity, antithrombotic activity, beta -lytic activity or platelet aggregation inhibiting activity, and/or activity on the central nervous system, for example a tranquillising activity.
SE7612554A 1975-11-18 1976-11-11 PROCEDURE FOR PREPARING AMINOAL ALCOHOL DERIVATIVES SE434744B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7535217A FR2332010A1 (en) 1975-11-18 1975-11-18 HETEROCYCLIC AMINO-ALCOHOL, ITS SALT AND ITS PREPARATION PROCESS

Publications (2)

Publication Number Publication Date
SE7612554L true SE7612554L (en) 1977-05-19
SE434744B SE434744B (en) 1984-08-13

Family

ID=9162563

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7612554A SE434744B (en) 1975-11-18 1976-11-11 PROCEDURE FOR PREPARING AMINOAL ALCOHOL DERIVATIVES

Country Status (21)

Country Link
JP (2) JPS5297952A (en)
AT (1) AT355566B (en)
AU (1) AU510315B2 (en)
BE (1) BE848496A (en)
CA (1) CA1094088A (en)
CH (2) CH623321A5 (en)
DE (1) DE2651572C2 (en)
DK (1) DK151330C (en)
ES (1) ES453389A1 (en)
FI (1) FI763265A (en)
FR (1) FR2332010A1 (en)
GB (1) GB1565080A (en)
GR (1) GR62012B (en)
IE (1) IE44265B1 (en)
IL (1) IL50932A (en)
MX (1) MX4881E (en)
NL (1) NL180936C (en)
NZ (1) NZ182665A (en)
PT (1) PT65853B (en)
SE (1) SE434744B (en)
ZA (1) ZA766907B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2512817A1 (en) * 1981-09-17 1983-03-18 Roussel Uclaf NOVEL AMINOMETHYL 1H-INDOLE-4-METHANOL DERIVATIVES AND THEIR SALTS, PROCESS FOR PREPARING THEM, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS COMPRISING THEM AND THEIR PREPARATION INTERMEDIATES
US4521606A (en) * 1983-06-30 1985-06-04 American Home Products Corp. 5-Indolyl substituted aminoethanols
US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
US4622399A (en) * 1983-06-30 1986-11-11 American Home Products Corporation Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives
DE69329084T2 (en) 1992-04-24 2000-12-21 Takeda Chemical Industries, Ltd. Benzoxazepine derivatives as cholinesterase inhibitors
US5541197A (en) * 1994-04-26 1996-07-30 Merck & Co., Inc. Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
US5705515A (en) * 1994-04-26 1998-01-06 Merck & Co., Inc. Substituted sulfonamides as selective β-3 agonists for the treatment of diabetes and obesity
US5561142A (en) * 1994-04-26 1996-10-01 Merck & Co., Inc. Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity
US5656661A (en) * 1994-07-27 1997-08-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents
US6037362A (en) 1996-01-10 2000-03-14 Asahi Kasei Kogyo Kabushiki Kaisha Tricyclic compounds and drug compositions containing the same
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
AU6218598A (en) * 1997-01-30 1998-08-25 Synthelabo Alpha-azacyclomethyl benzothiophene and alpha-azacyclomethyl benzofurane derivatives, preparation and therapeutic application
FR2758820B1 (en) * 1997-01-30 1999-02-26 Synthelabo ALPHA-AZACYCLOMETHYL-BENZOFURANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
KR100335169B1 (en) 1997-07-03 2002-05-04 야마모토 카즈모토 Novel Tricyclic Compounds Having Saturated Rings and Medicinal Compositions Containing the Same
CN1430603A (en) 2000-04-28 2003-07-16 旭化成株式会社 Novel bicyclic compounds
ES2309200T3 (en) 2001-10-25 2008-12-16 Asahi Kasei Pharma Corporation BICYCLE COMPOUND
JPWO2010041568A1 (en) 2008-10-09 2012-03-08 旭化成ファーマ株式会社 Indazole derivatives
AU2009301798B2 (en) 2008-10-09 2012-03-01 Asahi Kasei Pharma Corporation Indazole compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1013224A (en) * 1962-06-21 1965-12-15 Ici Ltd Heterocyclic aminoethanols
US3255249A (en) * 1963-04-26 1966-06-07 Ici Ltd 2-branched lower alkyl-amino-1-(indan-, hydrogenated indan- and hydrogenated naphth-2-yl) lower alkanols
CH442302A (en) * 1964-04-17 1967-08-31 Sandoz Ag Process for the production of a new indole derivative
FR2138488A1 (en) * 1971-05-27 1973-01-05 Lipha 1-(5-indanyl)-omega-aminoalkanes - with tranquillizing activity

Also Published As

Publication number Publication date
CH622770A5 (en) 1981-04-30
AU1977976A (en) 1978-05-25
IL50932A (en) 1984-01-31
FR2332010B1 (en) 1979-06-29
DE2651572C2 (en) 1982-05-19
SE434744B (en) 1984-08-13
NL180936C (en) 1987-05-18
ATA854376A (en) 1979-08-15
JPS63435B2 (en) 1988-01-07
PT65853B (en) 1978-05-15
AU510315B2 (en) 1980-06-19
IL50932A0 (en) 1977-01-31
GB1565080A (en) 1980-04-16
NZ182665A (en) 1978-11-13
JPS6017778B2 (en) 1985-05-07
NL180936B (en) 1986-12-16
DK517076A (en) 1977-05-19
FI763265A (en) 1977-05-19
DK151330C (en) 1988-04-25
CA1094088A (en) 1981-01-20
AT355566B (en) 1980-03-10
CH623321A5 (en) 1981-05-29
ES453389A1 (en) 1977-11-16
ZA766907B (en) 1977-10-26
JPS57145843A (en) 1982-09-09
BE848496A (en) 1977-05-18
FR2332010A1 (en) 1977-06-17
MX4881E (en) 1982-11-30
JPS5297952A (en) 1977-08-17
IE44265B1 (en) 1981-09-23
NL7612794A (en) 1977-05-23
GR62012B (en) 1979-02-15
DE2651572A1 (en) 1977-06-08
PT65853A (en) 1976-12-01
IE44265L (en) 1977-05-18
DK151330B (en) 1987-11-23

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