SE7609837L - PROCEDURE FOR THE MANUFACTURE OF MONOSPECIFIC ANTIBODIES REGARDING AN ANTIGEN - Google Patents
PROCEDURE FOR THE MANUFACTURE OF MONOSPECIFIC ANTIBODIES REGARDING AN ANTIGENInfo
- Publication number
- SE7609837L SE7609837L SE7609837A SE7609837A SE7609837L SE 7609837 L SE7609837 L SE 7609837L SE 7609837 A SE7609837 A SE 7609837A SE 7609837 A SE7609837 A SE 7609837A SE 7609837 L SE7609837 L SE 7609837L
- Authority
- SE
- Sweden
- Prior art keywords
- polypeptide antigen
- fraction
- solids
- antigen
- polypeptide
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 5
- 102000036639 antigens Human genes 0.000 title abstract 5
- 108091007433 antigens Proteins 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 7
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 239000007787 solid Substances 0.000 abstract 3
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000011324 bead Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002808 molecular sieve Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
To obtain a tumour polypeptide antigen, initially material with tumour polypeptide antigenic activity is homogenised in a liquid at a temperature not exceeding 0 DEG C. The solids are removed from the mixture of liquid homogenate and solids directly or after treatment with an organic solvent in the cold. The solids are extracted with an alkaline aqueous solution. The extract is filtered through a filtration gel of the molecular sieve type in bead form which permits fractionation of compounds with a molecular weight in the range from 10,000 to 20 x 10<6>, the gel is eluted and the fraction with a molecular weight of 10 x 10<6> to 20 x 10<6> is obtained. The resulting fraction is purified by chromatography. The fraction having antigenic activity is obtained and subjected to isoelectric precipitation by adding acid until the solubility of the polypeptides reaches a minimum as a consequence of the presence of the polypeptide molecules in the form of zwitterions. Subsequently, the polypeptide antigen is further purified. The resulting tumour polypeptide antigen can be used for the preparation of antibodies which are monospecific for the polypeptide antigen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27027372A | 1972-07-10 | 1972-07-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7609837L true SE7609837L (en) | 1976-09-06 |
| SE440597B SE440597B (en) | 1985-08-12 |
Family
ID=23030635
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7308917A SE440697B (en) | 1972-07-10 | 1973-06-25 | PROCEDURE FOR DIAGNOSTICATION OF CANCER BY DETERMINATION OF NERVARON OF CANCER CONNECTED POLYPEPTID ANTIGEN (CAPA) |
| SE7609837A SE440597B (en) | 1972-07-10 | 1976-09-06 | SET TO MANUFACTURE ANTIBODIES AGAINST A CANCER BUT THE POLYPEPTID ANTIGEN (CAPA) |
| SE7609836A SE418186B (en) | 1972-07-10 | 1976-09-06 | PROCEDURE FOR ISOLATING AN ADVANCED POLYPEPTIDE ANTIGEN |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7308917A SE440697B (en) | 1972-07-10 | 1973-06-25 | PROCEDURE FOR DIAGNOSTICATION OF CANCER BY DETERMINATION OF NERVARON OF CANCER CONNECTED POLYPEPTID ANTIGEN (CAPA) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7609836A SE418186B (en) | 1972-07-10 | 1976-09-06 | PROCEDURE FOR ISOLATING AN ADVANCED POLYPEPTIDE ANTIGEN |
Country Status (22)
| Country | Link |
|---|---|
| JP (2) | JPS5817168B2 (en) |
| AR (1) | AR197243A1 (en) |
| AT (1) | AT336780B (en) |
| BE (1) | BE802126A (en) |
| BR (1) | BR7305142D0 (en) |
| CA (1) | CA1039650A (en) |
| CH (1) | CH617853A5 (en) |
| DD (2) | DD113918A5 (en) |
| DE (2) | DE2366609C2 (en) |
| DK (1) | DK139898B (en) |
| ES (1) | ES416726A1 (en) |
| FI (1) | FI60567C (en) |
| FR (1) | FR2191885B1 (en) |
| GB (2) | GB1443053A (en) |
| IL (1) | IL42594A (en) |
| IN (1) | IN138903B (en) |
| IT (1) | IT1009527B (en) |
| NL (1) | NL7309257A (en) |
| NO (1) | NO146338C (en) |
| SE (3) | SE440697B (en) |
| SU (1) | SU581842A3 (en) |
| ZA (1) | ZA734632B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132769A (en) * | 1974-10-30 | 1979-01-02 | Osther Kurt B | Cancer antigen, cancer therapy, and cancer diagnosis |
| US4146603A (en) * | 1977-02-18 | 1979-03-27 | Research Corporation | Tumor specific glycoproteins and method for detecting tumorigenic cancers |
| US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| JPS56145297A (en) * | 1980-04-11 | 1981-11-11 | Kureha Chem Ind Co Ltd | Preparative method of glycoprotein having immunosupressing activity |
| NO830570L (en) * | 1982-02-22 | 1983-08-23 | Carlton Med Prod | ANTIBODIES AND ANTIGENS FOR CANCER DIAGNOSIS AND TREATMENT |
-
1973
- 1973-06-25 IL IL42594A patent/IL42594A/en unknown
- 1973-06-25 SE SE7308917A patent/SE440697B/en unknown
- 1973-06-25 IN IN1473/CAL/73A patent/IN138903B/en unknown
- 1973-06-29 FI FI2099/73A patent/FI60567C/en active
- 1973-07-03 NL NL7309257A patent/NL7309257A/xx not_active Application Discontinuation
- 1973-07-03 DE DE2366609A patent/DE2366609C2/de not_active Expired
- 1973-07-03 DE DE19732333740 patent/DE2333740A1/en active Granted
- 1973-07-06 CH CH988073A patent/CH617853A5/en not_active IP Right Cessation
- 1973-07-06 AR AR248979A patent/AR197243A1/en active
- 1973-07-06 DD DD172110A patent/DD113918A5/xx unknown
- 1973-07-06 DD DD186676*A patent/DD118946A5/xx unknown
- 1973-07-09 ES ES416726A patent/ES416726A1/en not_active Expired
- 1973-07-09 NO NO2807/73A patent/NO146338C/en unknown
- 1973-07-09 DK DK380773AA patent/DK139898B/en not_active IP Right Cessation
- 1973-07-09 IT IT26346/73A patent/IT1009527B/en active
- 1973-07-09 AT AT600773A patent/AT336780B/en not_active IP Right Cessation
- 1973-07-09 GB GB3263473A patent/GB1443053A/en not_active Expired
- 1973-07-09 GB GB4980974A patent/GB1443054A/en not_active Expired
- 1973-07-09 CA CA175,995A patent/CA1039650A/en not_active Expired
- 1973-07-10 SU SU7301949792A patent/SU581842A3/en active
- 1973-07-10 ZA ZA734632A patent/ZA734632B/en unknown
- 1973-07-10 BE BE133300A patent/BE802126A/en not_active IP Right Cessation
- 1973-07-10 BR BR5142/73A patent/BR7305142D0/en unknown
- 1973-07-10 FR FR7325241A patent/FR2191885B1/fr not_active Expired
- 1973-07-10 JP JP48077839A patent/JPS5817168B2/en not_active Expired
-
1976
- 1976-09-06 SE SE7609837A patent/SE440597B/en not_active IP Right Cessation
- 1976-09-06 SE SE7609836A patent/SE418186B/en not_active IP Right Cessation
-
1981
- 1981-01-14 JP JP56003331A patent/JPS6018011B2/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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