GB1443053A - Cancer associated polypeptide antigen process for its pre paration and composition useful as an immunizing agent - Google Patents
Cancer associated polypeptide antigen process for its pre paration and composition useful as an immunizing agentInfo
- Publication number
- GB1443053A GB1443053A GB3263473A GB3263473A GB1443053A GB 1443053 A GB1443053 A GB 1443053A GB 3263473 A GB3263473 A GB 3263473A GB 3263473 A GB3263473 A GB 3263473A GB 1443053 A GB1443053 A GB 1443053A
- Authority
- GB
- United Kingdom
- Prior art keywords
- polypeptide antigen
- fraction
- solids
- polypeptide
- tumour
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 8
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 8
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 239000000427 antigen Substances 0.000 title abstract 5
- 102000036639 antigens Human genes 0.000 title abstract 5
- 108091007433 antigens Proteins 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 229940124452 immunizing agent Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000007787 solid Substances 0.000 abstract 3
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000011324 bead Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000005194 fractionation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002808 molecular sieve Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
To obtain a tumour polypeptide antigen, initially material with tumour polypeptide antigenic activity is homogenised in a liquid at a temperature not exceeding 0 DEG C. The solids are removed from the mixture of liquid homogenate and solids directly or after treatment with an organic solvent in the cold. The solids are extracted with an alkaline aqueous solution. The extract is filtered through a filtration gel of the molecular sieve type in bead form which permits fractionation of compounds with a molecular weight in the range from 10,000 to 20 x 10<6>, the gel is eluted and the fraction with a molecular weight of 10 x 10<6> to 20 x 10<6> is obtained. The resulting fraction is purified by chromatography. The fraction having antigenic activity is obtained and subjected to isoelectric precipitation by adding acid until the solubility of the polypeptides reaches a minimum as a consequence of the presence of the polypeptide molecules in the form of zwitterions. Subsequently, the polypeptide antigen is further purified. The resulting tumour polypeptide antigen can be used for the preparation of antibodies which are monospecific for the polypeptide antigen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27027372A | 1972-07-10 | 1972-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1443053A true GB1443053A (en) | 1976-07-21 |
Family
ID=23030635
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3263473A Expired GB1443053A (en) | 1972-07-10 | 1973-07-09 | Cancer associated polypeptide antigen process for its pre paration and composition useful as an immunizing agent |
| GB4980974A Expired GB1443054A (en) | 1972-07-10 | 1973-07-09 | Process for preparing anti-bodies for cancer associated polypeptid antigen and process of cancer diagnosis |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4980974A Expired GB1443054A (en) | 1972-07-10 | 1973-07-09 | Process for preparing anti-bodies for cancer associated polypeptid antigen and process of cancer diagnosis |
Country Status (22)
| Country | Link |
|---|---|
| JP (2) | JPS5817168B2 (en) |
| AR (1) | AR197243A1 (en) |
| AT (1) | AT336780B (en) |
| BE (1) | BE802126A (en) |
| BR (1) | BR7305142D0 (en) |
| CA (1) | CA1039650A (en) |
| CH (1) | CH617853A5 (en) |
| DD (2) | DD118946A5 (en) |
| DE (2) | DE2333740C2 (en) |
| DK (1) | DK139898B (en) |
| ES (1) | ES416726A1 (en) |
| FI (1) | FI60567C (en) |
| FR (1) | FR2191885B1 (en) |
| GB (2) | GB1443053A (en) |
| IL (1) | IL42594A (en) |
| IN (1) | IN138903B (en) |
| IT (1) | IT1009527B (en) |
| NL (1) | NL7309257A (en) |
| NO (1) | NO146338C (en) |
| SE (3) | SE440697B (en) |
| SU (1) | SU581842A3 (en) |
| ZA (1) | ZA734632B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2121417A (en) * | 1982-02-22 | 1983-12-21 | Carlton Med Prod | Antigens and antibodies useful in the detection of cancer |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132769A (en) * | 1974-10-30 | 1979-01-02 | Osther Kurt B | Cancer antigen, cancer therapy, and cancer diagnosis |
| US4146603A (en) * | 1977-02-18 | 1979-03-27 | Research Corporation | Tumor specific glycoproteins and method for detecting tumorigenic cancers |
| US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
| JPS56145297A (en) * | 1980-04-11 | 1981-11-11 | Kureha Chem Ind Co Ltd | Preparative method of glycoprotein having immunosupressing activity |
-
1973
- 1973-06-25 IN IN1473/CAL/73A patent/IN138903B/en unknown
- 1973-06-25 SE SE7308917A patent/SE440697B/en unknown
- 1973-06-25 IL IL42594A patent/IL42594A/en unknown
- 1973-06-29 FI FI2099/73A patent/FI60567C/en active
- 1973-07-03 DE DE2333740A patent/DE2333740C2/en not_active Expired
- 1973-07-03 NL NL7309257A patent/NL7309257A/xx not_active Application Discontinuation
- 1973-07-03 DE DE2366609A patent/DE2366609C2/de not_active Expired
- 1973-07-06 DD DD186676*A patent/DD118946A5/xx unknown
- 1973-07-06 AR AR248979A patent/AR197243A1/en active
- 1973-07-06 DD DD172110A patent/DD113918A5/xx unknown
- 1973-07-06 CH CH988073A patent/CH617853A5/en not_active IP Right Cessation
- 1973-07-09 ES ES416726A patent/ES416726A1/en not_active Expired
- 1973-07-09 AT AT600773A patent/AT336780B/en not_active IP Right Cessation
- 1973-07-09 IT IT26346/73A patent/IT1009527B/en active
- 1973-07-09 GB GB3263473A patent/GB1443053A/en not_active Expired
- 1973-07-09 GB GB4980974A patent/GB1443054A/en not_active Expired
- 1973-07-09 CA CA175,995A patent/CA1039650A/en not_active Expired
- 1973-07-09 NO NO2807/73A patent/NO146338C/en unknown
- 1973-07-09 DK DK380773AA patent/DK139898B/en not_active IP Right Cessation
- 1973-07-10 FR FR7325241A patent/FR2191885B1/fr not_active Expired
- 1973-07-10 ZA ZA734632A patent/ZA734632B/en unknown
- 1973-07-10 JP JP48077839A patent/JPS5817168B2/en not_active Expired
- 1973-07-10 BE BE133300A patent/BE802126A/en not_active IP Right Cessation
- 1973-07-10 SU SU7301949792A patent/SU581842A3/en active
- 1973-07-10 BR BR5142/73A patent/BR7305142D0/en unknown
-
1976
- 1976-09-06 SE SE7609836A patent/SE418186B/en not_active IP Right Cessation
- 1976-09-06 SE SE7609837A patent/SE440597B/en not_active IP Right Cessation
-
1981
- 1981-01-14 JP JP56003331A patent/JPS6018011B2/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2121417A (en) * | 1982-02-22 | 1983-12-21 | Carlton Med Prod | Antigens and antibodies useful in the detection of cancer |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19930708 |