SE7606795L - WAY TO PREPARE A NEW DESOXISTREPTAMIN DERIVATIVE AND ITS SALTS - Google Patents

WAY TO PREPARE A NEW DESOXISTREPTAMIN DERIVATIVE AND ITS SALTS

Info

Publication number
SE7606795L
SE7606795L SE7606795A SE7606795A SE7606795L SE 7606795 L SE7606795 L SE 7606795L SE 7606795 A SE7606795 A SE 7606795A SE 7606795 A SE7606795 A SE 7606795A SE 7606795 L SE7606795 L SE 7606795L
Authority
SE
Sweden
Prior art keywords
alpha
desoxystreptamine
xylohexopyranosyl
tridesoxy
didesoxy
Prior art date
Application number
SE7606795A
Other languages
Swedish (sv)
Other versions
SE427461B (en
Inventor
J-B Chazan
J-C Gasc
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of SE7606795L publication Critical patent/SE7606795L/en
Publication of SE427461B publication Critical patent/SE427461B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

1502537 2 - Desoxy - streptamine derivatives ROUSSEL-UCLAF 23 July 1976 [23 July 1975] 30746/76 Heading C2C Novel N 1 - [L(-) - 2 - hydroxy - 4 - aminobutyryl] - 4 - O - [2<SP>1</SP>,6<SP>1</SP> - diamino - 2<SP>1</SP>,6<SP>1</SP> - didesoxy - &alpha;,D - glucopyranosyl] - 6 - O - [3<SP>11</SP>- methylamino - 3<SP>11</SP>,4<SP>11</SP>,6<SP>11</SP> - tridesoxy - &alpha;,D- xylohexopyranosyl] - 2 - desoxystreptamine (I) and addition salts thereof with mineral or organic acids are prepared by reacting 4-O- [2<SP>1</SP>,6<SP>1</SP> - diamino - 21,61 - didesoxy - &alpha;,D - glucopyranosyl] - 6 - O - [3<SP>11</SP> - methylamino - 3<SP>11</SP>,4<SP>11</SP>, 6<SP>11</SP> - tridesoxy - &alpha;,D - xylohexopyranosyl] - 2- desoxystreptamine with N - benzyloxycarbonyloxy-succinimide, reacting the resulting novel 4 - O - [21 - amino - 61 - benzyloxycarbonylamino - 2<SP>1</SP>,6<SP>1</SP> - didesoxy - &alpha;,D - glucopyranosyl] - 6 - O - [3<SP>11</SP> - methylamino - 3<SP>11</SP>,4<SP>11</SP>, 6<SP>11</SP> - tridesoxy - &alpha;,D - xylohexopyranosyl] - 2- desoxystreptamine with the N-hydroxysuccinimide ester of L-(-)-&gamma;-benzyloxycarbonylamino - &alpha; - hydroxy - butyric acid and catalytically hydrogenating the resulting novel N 1 - [L - (-) - 2 - hydroxy - 4 - benzyloxycarbonylamino - butyryl] - 4 - O - [2<SP>1</SP> - amino- 61 - benzyloxycarbonylamino - 2<SP>1</SP>,6<SP>1</SP> - didesoxy- &alpha;,D - glucopyranosyl] - 6 - O - [3<SP>11</SP> - methylamino - 3<SP>11</SP>,4<SP>11</SP>,6<SP>11</SP> - tridesoxy - &alpha;,D - xylohexopyranosyl] - 2 - desoxystreptamine, followed optionally by salification with an appropriate acid. Pharmaceutical compositions having antibiotic activity comprise, as active ingredient, the compound (I) or a pharmaceutically acceptable mineral or organic acid addition salt thereof, in association with a suitable pharmaceutical vehicle.
SE7606795A 1975-07-23 1976-06-15 SET TO MAKE A NEW DESOXISTREPTAMIN DERIVATIVE AND ITS THERAPEUTIC PORTABLE SALTS SE427461B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7522987A FR2318648A1 (en) 1975-07-23 1975-07-23 NEW DERIVATIVE OF DESOXYSTREPTAMINE AND SALTS, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
SE7606795L true SE7606795L (en) 1977-01-24
SE427461B SE427461B (en) 1983-04-11

Family

ID=9158255

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7606795A SE427461B (en) 1975-07-23 1976-06-15 SET TO MAKE A NEW DESOXISTREPTAMIN DERIVATIVE AND ITS THERAPEUTIC PORTABLE SALTS

Country Status (19)

Country Link
JP (1) JPS5214746A (en)
AT (1) AT344902B (en)
AU (1) AU503819B2 (en)
BE (1) BE843535A (en)
CH (1) CH598281A5 (en)
DD (1) DD126770A5 (en)
DE (1) DE2630590C2 (en)
DK (1) DK149186C (en)
ES (1) ES450028A1 (en)
FR (1) FR2318648A1 (en)
GB (1) GB1502537A (en)
HU (1) HU175411B (en)
IE (1) IE43582B1 (en)
IL (1) IL49900A (en)
LU (1) LU75266A1 (en)
NL (1) NL7608151A (en)
SE (1) SE427461B (en)
SU (1) SU656528A3 (en)
ZA (1) ZA763895B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435481A1 (en) * 1978-09-06 1980-04-04 Roussel Uclaf NOVEL AMINOGLYCOSIDES DERIVED FROM DESOXYSTREPTAMINE AND SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND APPLICATION AS MEDICAMENTS
USD975431S1 (en) * 2020-12-18 2023-01-17 Wonderland Switzerland Ag Infant carrier

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE786201A (en) * 1971-07-13 1973-01-12 Bristol Myers Co METHOD FOR PREPARING ANTIBIOTICS
FR2228474A1 (en) * 1973-05-10 1974-12-06 Roussel Uclaf Amino-glycoside deriv as an antibacterial agent - prepd by a stepwise process from a substd 2-O-ethoxycarbonyl D-xylohexopyranoside
US3959255A (en) 1973-05-10 1976-05-25 Roussel-Uclaf Antibiotic aminoglycosides, and process of preparation

Also Published As

Publication number Publication date
SE427461B (en) 1983-04-11
SU656528A3 (en) 1979-04-05
DD126770A5 (en) 1977-08-10
IE43582L (en) 1977-01-23
AT344902B (en) 1978-08-25
ES450028A1 (en) 1977-08-01
FR2318648B1 (en) 1978-10-06
JPS5214746A (en) 1977-02-03
CH598281A5 (en) 1978-04-28
AU503819B2 (en) 1979-09-20
NL7608151A (en) 1977-01-25
AU1608376A (en) 1978-01-26
GB1502537A (en) 1978-03-01
DK149186B (en) 1986-03-10
LU75266A1 (en) 1977-03-18
IE43582B1 (en) 1981-04-08
FR2318648A1 (en) 1977-02-18
ATA545176A (en) 1977-12-15
DE2630590C2 (en) 1984-08-09
DE2630590A1 (en) 1977-02-10
DK149186C (en) 1986-09-15
ZA763895B (en) 1977-08-31
HU175411B (en) 1980-07-28
IL49900A (en) 1979-05-31
JPS619318B2 (en) 1986-03-22
IL49900A0 (en) 1976-08-31
BE843535A (en) 1976-12-29
DK329876A (en) 1977-01-24

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