SE7600284L - THERAPEUTIC INSULIN PREPARATION. - Google Patents

THERAPEUTIC INSULIN PREPARATION.

Info

Publication number
SE7600284L
SE7600284L SE7600284A SE7600284A SE7600284L SE 7600284 L SE7600284 L SE 7600284L SE 7600284 A SE7600284 A SE 7600284A SE 7600284 A SE7600284 A SE 7600284A SE 7600284 L SE7600284 L SE 7600284L
Authority
SE
Sweden
Prior art keywords
protein
basic
insulin preparation
dissociating
reaction
Prior art date
Application number
SE7600284A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE437219B (en
Inventor
B A Hansen
F H Andresen
Original Assignee
Nordisk Insulinlab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordisk Insulinlab filed Critical Nordisk Insulinlab
Publication of SE7600284L publication Critical patent/SE7600284L/en
Publication of SE437219B publication Critical patent/SE437219B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • C07K14/625Extraction from natural sources
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A stable insulin preparation having a lasting action and having low antigenicity is prepared by reaction of acidic groups of the insulin with basic groups of organic compounds. The reaction is carried out in an aqueous buffer solution which contains a protein-dissociating or protein-depolymerising agent. Basic polypeptides, e.g. protamines, or cleavage products of basic polypeptides are preferred as organic compounds containing a basic group. The protein-dissociating or protein-depolymerising agent is preferably urea.
SE7600284A 1975-01-15 1976-01-13 PROCEDURE FOR PREPARING A STABLE INSULIN PREPARATION WITH PROTRAHERED EFFECT SE437219B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK8375AA DK140801B (en) 1975-01-15 1975-01-15 Process for the preparation of a stable long-acting insulin preparation.

Publications (2)

Publication Number Publication Date
SE7600284L true SE7600284L (en) 1976-07-16
SE437219B SE437219B (en) 1985-02-18

Family

ID=8089535

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7600284A SE437219B (en) 1975-01-15 1976-01-13 PROCEDURE FOR PREPARING A STABLE INSULIN PREPARATION WITH PROTRAHERED EFFECT

Country Status (36)

Country Link
JP (1) JPS5946939B2 (en)
AR (1) AR213088A1 (en)
AT (1) AT362492B (en)
BE (1) BE837600A (en)
BR (1) BR7600206A (en)
CA (1) CA1094549A (en)
CH (1) CH631625A5 (en)
CS (1) CS208147B2 (en)
DD (1) DD124379A5 (en)
DE (1) DE2600971C2 (en)
DK (1) DK140801B (en)
EG (1) EG11988A (en)
ES (1) ES444558A1 (en)
FI (1) FI66751C (en)
FR (1) FR2297634A1 (en)
GB (1) GB1524431A (en)
GR (1) GR58608B (en)
HU (1) HU175142B (en)
IE (1) IE42395B1 (en)
IL (1) IL48845A (en)
IN (1) IN143279B (en)
IT (1) IT1054211B (en)
KE (1) KE2919A (en)
LU (1) LU74175A1 (en)
MX (1) MX4052E (en)
MY (1) MY7900169A (en)
NL (1) NL166464C (en)
NO (1) NO146698C (en)
NZ (1) NZ179733A (en)
OA (1) OA05209A (en)
PL (1) PL99927B1 (en)
PT (1) PT64696B (en)
RO (1) RO71576A (en)
SE (1) SE437219B (en)
YU (1) YU8376A (en)
ZA (1) ZA7658B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK374579A (en) * 1979-09-07 1981-03-08 Nordisk Insulinlab PROCEDURE FOR THE PREPARATION OF AN INJUCABLE INSULIN PREPARATION
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
US4801575A (en) * 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
AU609769B2 (en) * 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US4878892A (en) * 1987-02-10 1989-11-07 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5447728A (en) 1992-06-15 1995-09-05 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
EP2662472B1 (en) 2009-03-31 2019-02-27 Boehringer Ingelheim International Gmbh Method for coating a surface of a component
US9265910B2 (en) 2009-05-18 2016-02-23 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and nebulizer
EP2504052B1 (en) 2009-11-25 2022-07-27 Boehringer Ingelheim International GmbH Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
JP5658268B2 (en) 2009-11-25 2015-01-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Nebulizer
EP2585151B1 (en) 2010-06-24 2018-04-04 Boehringer Ingelheim International GmbH Nebulizer
EP2694220B1 (en) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medical device comprising a container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (en) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Atomiser with coding means
EP3030298B1 (en) 2013-08-09 2017-10-11 Boehringer Ingelheim International GmbH Nebulizer
ES2836977T3 (en) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizer
ES2954961T3 (en) 2014-05-07 2023-11-27 Boehringer Ingelheim Int Unit, nebulizer and method
DK3139984T3 (en) 2014-05-07 2021-07-19 Boehringer Ingelheim Int Atomizer
RS64124B1 (en) 2014-05-07 2023-05-31 Boehringer Ingelheim Int Nebulizer and container

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1285023A (en) * 1968-08-09 1972-08-09 Novo Terapeutisk Labor As Improvements in or relating to injectable insulin preparations
US3758683A (en) * 1971-04-30 1973-09-11 R Jackson Insulin product

Also Published As

Publication number Publication date
HU175142B (en) 1980-05-28
AU1030776A (en) 1977-07-21
IE42395B1 (en) 1980-07-30
FR2297634A1 (en) 1976-08-13
PT64696A (en) 1976-02-01
NO760118L (en) 1976-07-16
RO71576A (en) 1980-12-30
BE837600A (en) 1976-07-15
IE42395L (en) 1976-07-15
MX4052E (en) 1981-11-24
EG11988A (en) 1978-06-30
IT1054211B (en) 1981-11-10
GB1524431A (en) 1978-09-13
CH631625A5 (en) 1982-08-31
NL7600338A (en) 1976-07-19
ZA7658B (en) 1976-12-29
AT362492B (en) 1981-05-25
NO146698C (en) 1982-11-24
PT64696B (en) 1977-08-10
FI760058A (en) 1976-07-16
PL99927B1 (en) 1978-08-31
CA1094549A (en) 1981-01-27
DK140801C (en) 1980-04-21
BR7600206A (en) 1976-08-31
ATA21376A (en) 1980-10-15
YU8376A (en) 1982-06-30
NZ179733A (en) 1978-04-28
ES444558A1 (en) 1977-05-16
SE437219B (en) 1985-02-18
NO146698B (en) 1982-08-16
JPS5946939B2 (en) 1984-11-15
IL48845A (en) 1981-06-29
NL166464B (en) 1981-03-16
AR213088A1 (en) 1978-12-15
NL166464C (en) 1981-08-17
IL48845A0 (en) 1976-03-31
KE2919A (en) 1979-03-30
DK140801B (en) 1979-11-19
DE2600971A1 (en) 1976-07-22
JPS51125299A (en) 1976-11-01
LU74175A1 (en) 1977-03-18
DD124379A5 (en) 1977-02-16
DE2600971C2 (en) 1985-12-12
GR58608B (en) 1977-11-10
MY7900169A (en) 1979-12-31
FI66751C (en) 1984-12-10
DK8375A (en) 1976-07-16
FR2297634B1 (en) 1979-03-30
IN143279B (en) 1977-10-29
FI66751B (en) 1984-08-31
OA05209A (en) 1981-02-28
CS208147B2 (en) 1981-08-31

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