SE7600284L - THERAPEUTIC INSULIN PREPARATION. - Google Patents
THERAPEUTIC INSULIN PREPARATION.Info
- Publication number
- SE7600284L SE7600284L SE7600284A SE7600284A SE7600284L SE 7600284 L SE7600284 L SE 7600284L SE 7600284 A SE7600284 A SE 7600284A SE 7600284 A SE7600284 A SE 7600284A SE 7600284 L SE7600284 L SE 7600284L
- Authority
- SE
- Sweden
- Prior art keywords
- protein
- basic
- insulin preparation
- dissociating
- reaction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
A stable insulin preparation having a lasting action and having low antigenicity is prepared by reaction of acidic groups of the insulin with basic groups of organic compounds. The reaction is carried out in an aqueous buffer solution which contains a protein-dissociating or protein-depolymerising agent. Basic polypeptides, e.g. protamines, or cleavage products of basic polypeptides are preferred as organic compounds containing a basic group. The protein-dissociating or protein-depolymerising agent is preferably urea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK8375AA DK140801B (en) | 1975-01-15 | 1975-01-15 | Process for the preparation of a stable long-acting insulin preparation. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7600284L true SE7600284L (en) | 1976-07-16 |
| SE437219B SE437219B (en) | 1985-02-18 |
Family
ID=8089535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7600284A SE437219B (en) | 1975-01-15 | 1976-01-13 | PROCEDURE FOR PREPARING A STABLE INSULIN PREPARATION WITH PROTRAHERED EFFECT |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5946939B2 (en) |
| AR (1) | AR213088A1 (en) |
| AT (1) | AT362492B (en) |
| BE (1) | BE837600A (en) |
| BR (1) | BR7600206A (en) |
| CA (1) | CA1094549A (en) |
| CH (1) | CH631625A5 (en) |
| CS (1) | CS208147B2 (en) |
| DD (1) | DD124379A5 (en) |
| DE (1) | DE2600971C2 (en) |
| DK (1) | DK140801B (en) |
| EG (1) | EG11988A (en) |
| ES (1) | ES444558A1 (en) |
| FI (1) | FI66751C (en) |
| FR (1) | FR2297634A1 (en) |
| GB (1) | GB1524431A (en) |
| GR (1) | GR58608B (en) |
| HU (1) | HU175142B (en) |
| IE (1) | IE42395B1 (en) |
| IL (1) | IL48845A (en) |
| IN (1) | IN143279B (en) |
| IT (1) | IT1054211B (en) |
| KE (1) | KE2919A (en) |
| LU (1) | LU74175A1 (en) |
| MX (1) | MX4052E (en) |
| MY (1) | MY7900169A (en) |
| NL (1) | NL166464C (en) |
| NO (1) | NO146698C (en) |
| NZ (1) | NZ179733A (en) |
| OA (1) | OA05209A (en) |
| PL (1) | PL99927B1 (en) |
| PT (1) | PT64696B (en) |
| RO (1) | RO71576A (en) |
| SE (1) | SE437219B (en) |
| YU (1) | YU8376A (en) |
| ZA (1) | ZA7658B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK374579A (en) * | 1979-09-07 | 1981-03-08 | Nordisk Insulinlab | PROCEDURE FOR THE PREPARATION OF AN INJUCABLE INSULIN PREPARATION |
| US4459226A (en) * | 1982-02-26 | 1984-07-10 | Eli Lilly And Company | Process for recovering insulin |
| US4801575A (en) * | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| AU609769B2 (en) * | 1987-02-10 | 1991-05-09 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of proteins |
| US4878892A (en) * | 1987-02-10 | 1989-11-07 | Drug Delivery Systems Inc. | Electrolytic transdermal delivery of polypeptides |
| US5447728A (en) | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US5714167A (en) | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
| US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US5643957A (en) | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
| US6051258A (en) | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
| EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
| EP2414560B1 (en) | 2009-03-31 | 2013-10-23 | Boehringer Ingelheim International GmbH | Method for coating a surface of a component |
| WO2010133294A2 (en) | 2009-05-18 | 2010-11-25 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
| JP5658268B2 (en) | 2009-11-25 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Nebulizer |
| US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
| CN102686260B (en) | 2009-11-25 | 2014-10-01 | 贝林格尔.英格海姆国际有限公司 | Nebulizer |
| US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2012130757A1 (en) | 2011-04-01 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Medical device comprising a container |
| US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
| WO2013152894A1 (en) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Atomiser with coding means |
| US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
| ES2836977T3 (en) | 2013-08-09 | 2021-06-28 | Boehringer Ingelheim Int | Nebulizer |
| EP3139979B1 (en) | 2014-05-07 | 2023-07-05 | Boehringer Ingelheim International GmbH | Unit, nebulizer and method |
| UA121114C2 (en) | 2014-05-07 | 2020-04-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Nebulizer, indicator device and container |
| ES2874029T3 (en) | 2014-05-07 | 2021-11-04 | Boehringer Ingelheim Int | Nebulizer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1285023A (en) * | 1968-08-09 | 1972-08-09 | Novo Terapeutisk Labor As | Improvements in or relating to injectable insulin preparations |
| US3758683A (en) * | 1971-04-30 | 1973-09-11 | R Jackson | Insulin product |
-
1975
- 1975-01-15 DK DK8375AA patent/DK140801B/en not_active IP Right Cessation
-
1976
- 1976-01-06 ZA ZA00760058A patent/ZA7658B/en unknown
- 1976-01-07 GR GR49734A patent/GR58608B/en unknown
- 1976-01-07 IN IN41/CAL/76A patent/IN143279B/en unknown
- 1976-01-12 NZ NZ179733A patent/NZ179733A/en unknown
- 1976-01-12 FI FI760058A patent/FI66751C/en not_active IP Right Cessation
- 1976-01-12 CA CA243,587A patent/CA1094549A/en not_active Expired
- 1976-01-13 IE IE62/76A patent/IE42395B1/en unknown
- 1976-01-13 IT IT19221/76A patent/IT1054211B/en active
- 1976-01-13 SE SE7600284A patent/SE437219B/en not_active IP Right Cessation
- 1976-01-13 LU LU74175A patent/LU74175A1/xx unknown
- 1976-01-13 DE DE2600971A patent/DE2600971C2/en not_active Expired
- 1976-01-14 BR BR7600206A patent/BR7600206A/en unknown
- 1976-01-14 PL PL1976186526A patent/PL99927B1/en unknown
- 1976-01-14 AT AT21376A patent/AT362492B/en not_active IP Right Cessation
- 1976-01-14 NO NO760118A patent/NO146698C/en unknown
- 1976-01-14 OA OA55703A patent/OA05209A/en unknown
- 1976-01-14 DD DD190805A patent/DD124379A5/xx unknown
- 1976-01-14 FR FR7600854A patent/FR2297634A1/en active Granted
- 1976-01-14 GB GB1309/76A patent/GB1524431A/en not_active Expired
- 1976-01-14 RO RO7684491A patent/RO71576A/en unknown
- 1976-01-14 YU YU00083/76A patent/YU8376A/en unknown
- 1976-01-14 NL NL7600338.A patent/NL166464C/en not_active IP Right Cessation
- 1976-01-14 PT PT64696A patent/PT64696B/en unknown
- 1976-01-14 MX MX764822U patent/MX4052E/en unknown
- 1976-01-15 CS CS76270A patent/CS208147B2/en unknown
- 1976-01-15 CH CH47076A patent/CH631625A5/en not_active IP Right Cessation
- 1976-01-15 ES ES444558A patent/ES444558A1/en not_active Expired
- 1976-01-15 HU HU76NO198A patent/HU175142B/en unknown
- 1976-01-15 IL IL48845A patent/IL48845A/en unknown
- 1976-01-15 BE BE163542A patent/BE837600A/en not_active IP Right Cessation
- 1976-01-16 JP JP51003293A patent/JPS5946939B2/en not_active Expired
- 1976-01-17 EG EG16/76A patent/EG11988A/en active
-
1978
- 1978-01-14 AR AR261924A patent/AR213088A1/en active
-
1979
- 1979-02-07 KE KE2919A patent/KE2919A/en unknown
- 1979-12-30 MY MY169/79A patent/MY7900169A/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7600284-9 Effective date: 19891201 Format of ref document f/p: F |