SE7508208L - PROCEDURE FOR THE PREPARATION OF BENSODIAZEPINE DERIVATIVES. - Google Patents
PROCEDURE FOR THE PREPARATION OF BENSODIAZEPINE DERIVATIVES.Info
- Publication number
- SE7508208L SE7508208L SE7508208A SE7508208A SE7508208L SE 7508208 L SE7508208 L SE 7508208L SE 7508208 A SE7508208 A SE 7508208A SE 7508208 A SE7508208 A SE 7508208A SE 7508208 L SE7508208 L SE 7508208L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- formula
- derivatives
- oct
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
- A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Rehabilitation Therapy (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Harvester Elements (AREA)
Abstract
1,233,489. Benzodiazepine derivatives. F. HOFFMANNLA ROCHE & CO. A.G. 10 Oct., 1969 [18 Oct., 1968], No. 49746/69. Heading C2C. Compounds of the general formula (A = CH 2 , CO; Z = O, NH, N-(C 1-7 alkyl), N- acyl; R 1 = H, halogen, NO 2 , CF 3 , C 1-7 alkyl, C 1-7 alkylmercapto, C 1-7 alkoxy; R2 = H, C 1-7 alkyl, C 3-6 cycloalkyl, C 1-7 hydroxyalkyl; R 3 = H, C 1-7 alkyl; Y = (CH 2 ) 2 , 3 optionally substituted by C 1-7 alkyl, CH 2 Cl, CH 2 Br, C 1-7 alkoxy- (C 1-8 alkyl), di-(C 1-7 alkyl)aminomethyl; R 5 = H, C 1-7 alkyl, Py, Ph optionally substituted by halogen, NO 2 , CF 3 , C 1-7 alkyl) are prepared by (a) cyclizing a compound of the formula optionally followed by alkylation or acylation or (b) reacting a compound of the formula with oxirane or a derivative thereof in the presence of an acidic agent, optionally followed in either case by separation of an isomer mixture. The above compounds are sedatives, muscle relaxants and anticonvulsants, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76890968A | 1968-10-18 | 1968-10-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7508208L true SE7508208L (en) | 1975-07-17 |
| SE420409B SE420409B (en) | 1981-10-05 |
Family
ID=25083843
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE6914318A SE382983B (en) | 1968-10-18 | 1969-10-17 | ANALOGICAL PROCEDURE FOR THE PREPARATION OF OXAZOLO (3,2-D) (1,4) BENZODIAZEPINE DERIVATIVES |
| SE7215570A SE398232B (en) | 1968-10-18 | 1972-11-29 | PROCEDURE FOR THE PREPARATION OF BENSODIAZEPINE DERIVATIVES |
| SE7508208A SE420409B (en) | 1968-10-18 | 1975-07-17 | PROCEDURE FOR THE PREPARATION OF OXAZOLO (3,2-D) (1,4) BENZODIAZEPINES |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE6914318A SE382983B (en) | 1968-10-18 | 1969-10-17 | ANALOGICAL PROCEDURE FOR THE PREPARATION OF OXAZOLO (3,2-D) (1,4) BENZODIAZEPINE DERIVATIVES |
| SE7215570A SE398232B (en) | 1968-10-18 | 1972-11-29 | PROCEDURE FOR THE PREPARATION OF BENSODIAZEPINE DERIVATIVES |
Country Status (20)
| Country | Link |
|---|---|
| JP (2) | JPS4925278B1 (en) |
| AT (3) | AT306037B (en) |
| BE (1) | BE740347A (en) |
| BR (1) | BR6913309D0 (en) |
| CA (1) | CA1041498A (en) |
| CH (2) | CH562247A5 (en) |
| DE (1) | DE1952486A1 (en) |
| DK (1) | DK149817C (en) |
| ES (1) | ES372620A1 (en) |
| FI (1) | FI50984C (en) |
| FR (1) | FR2021010B1 (en) |
| GB (1) | GB1233489A (en) |
| HU (1) | HU166865B (en) |
| IE (1) | IE34252B1 (en) |
| IL (1) | IL33103A (en) |
| MY (1) | MY7500083A (en) |
| NL (1) | NL156141B (en) |
| NO (1) | NO127504B (en) |
| SE (3) | SE382983B (en) |
| YU (1) | YU34205B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1812252C2 (en) * | 1968-11-26 | 1981-09-24 | Sankyo Co., Ltd., Tokyo | Benzodiazepine derivatives, processes for their preparation and pharmaceuticals |
| CH565180A5 (en) * | 1970-12-23 | 1975-08-15 | Hoffmann La Roche | |
| FR2403330A1 (en) * | 1977-06-16 | 1979-04-13 | Fabre Sa Pierre | NEW DERIVATIVES OF BENZOYL-2-CHLORO-4-GLYCINANILIDES SUBSTITUTES, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS |
| AU538998B2 (en) * | 1980-06-27 | 1984-09-06 | Wahl Clipper Corp. | Cushioned massager |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1812252C2 (en) * | 1968-11-26 | 1981-09-24 | Sankyo Co., Ltd., Tokyo | Benzodiazepine derivatives, processes for their preparation and pharmaceuticals |
-
1969
- 1969-09-30 CA CA063,875A patent/CA1041498A/en not_active Expired
- 1969-09-30 IL IL33103A patent/IL33103A/en unknown
- 1969-10-07 CH CH559472A patent/CH562247A5/xx not_active IP Right Cessation
- 1969-10-07 CH CH1502469A patent/CH554361A/en not_active IP Right Cessation
- 1969-10-10 GB GB1233489D patent/GB1233489A/en not_active Expired
- 1969-10-10 DK DK542069A patent/DK149817C/en not_active IP Right Cessation
- 1969-10-13 NO NO04080/69A patent/NO127504B/no unknown
- 1969-10-15 IE IE1417/69A patent/IE34252B1/en unknown
- 1969-10-15 BR BR213309/69A patent/BR6913309D0/en unknown
- 1969-10-15 FI FI692974A patent/FI50984C/en active
- 1969-10-16 YU YU2604/69A patent/YU34205B/en unknown
- 1969-10-16 BE BE740347D patent/BE740347A/xx not_active IP Right Cessation
- 1969-10-17 FR FR696935610A patent/FR2021010B1/fr not_active Expired
- 1969-10-17 AT ATA924/72A patent/AT306037B/en not_active IP Right Cessation
- 1969-10-17 AT AT00925/72A patent/AT303747B/en not_active IP Right Cessation
- 1969-10-17 SE SE6914318A patent/SE382983B/en unknown
- 1969-10-17 NL NL6915750.A patent/NL156141B/en not_active IP Right Cessation
- 1969-10-17 AT AT981069A patent/AT302305B/en not_active IP Right Cessation
- 1969-10-17 HU HUHO1226A patent/HU166865B/hu unknown
- 1969-10-17 DE DE19691952486 patent/DE1952486A1/en active Granted
- 1969-10-17 ES ES372620A patent/ES372620A1/en not_active Expired
- 1969-10-18 JP JP44082993A patent/JPS4925278B1/ja active Pending
-
1972
- 1972-11-29 SE SE7215570A patent/SE398232B/en unknown
-
1973
- 1973-01-12 JP JP48006492A patent/JPS4927199B1/ja active Pending
-
1975
- 1975-07-17 SE SE7508208A patent/SE420409B/en not_active IP Right Cessation
- 1975-12-30 MY MY83/75A patent/MY7500083A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL156141B (en) | 1978-03-15 |
| DE1952486C2 (en) | 1988-06-23 |
| HU166865B (en) | 1975-06-28 |
| YU260469A (en) | 1978-06-30 |
| IL33103A0 (en) | 1969-11-30 |
| BE740347A (en) | 1970-04-16 |
| SE382983B (en) | 1976-02-23 |
| SE420409B (en) | 1981-10-05 |
| BR6913309D0 (en) | 1973-01-04 |
| JPS4927199B1 (en) | 1974-07-16 |
| FI50984C (en) | 1976-09-10 |
| MY7500083A (en) | 1975-12-31 |
| GB1233489A (en) | 1971-05-26 |
| AT303747B (en) | 1972-11-15 |
| FR2021010B1 (en) | 1973-07-13 |
| IE34252L (en) | 1970-04-18 |
| IE34252B1 (en) | 1975-03-19 |
| JPS4925278B1 (en) | 1974-06-28 |
| NL6915750A (en) | 1970-04-21 |
| IL33103A (en) | 1974-06-30 |
| YU34205B (en) | 1979-02-28 |
| SE398232B (en) | 1977-12-12 |
| ES372620A1 (en) | 1972-03-16 |
| CH562247A5 (en) | 1975-05-30 |
| AT302305B (en) | 1972-10-10 |
| CH554361A (en) | 1974-09-30 |
| FR2021010A1 (en) | 1970-07-17 |
| AT306037B (en) | 1973-02-15 |
| FI50984B (en) | 1976-05-31 |
| DK149817B (en) | 1986-10-06 |
| NO127504B (en) | 1973-07-02 |
| DK149817C (en) | 1987-04-06 |
| CA1041498A (en) | 1978-10-31 |
| DE1952486A1 (en) | 1970-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7508208-1 Effective date: 19891020 Format of ref document f/p: F |