SE7501878L - - Google Patents

Info

Publication number
SE7501878L
SE7501878L SE7501878A SE7501878A SE7501878L SE 7501878 L SE7501878 L SE 7501878L SE 7501878 A SE7501878 A SE 7501878A SE 7501878 A SE7501878 A SE 7501878A SE 7501878 L SE7501878 L SE 7501878L
Authority
SE
Sweden
Prior art keywords
hydroxyphenyl
image
group
cephalosporin
formula
Prior art date
Application number
SE7501878A
Other languages
Unknown language ( )
Inventor
P H Bentley
J P Clayton
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of SE7501878L publication Critical patent/SE7501878L/

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Novel pharmacologically active cephalosporin esters of the formula I are prepared <IMAGE> in which R is a phenyl, 4-hydroxyphenyl, 3-chloro-4-hydroxyphenyl, 2- or 3-thienyl or dihydrophenyl group, X is an acetoxy, carbamoyloxy or a heterocyclic thio group and R<1> and R<2> are hydrogen or methoxy, by reacting an appropriate compound which has an amino group in the 7-position of the cephalosporin radical with a reactive, N-acylating derivative of an acid of the formula VII <IMAGE>
SE7501878A 1974-02-21 1975-02-19 SE7501878L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7860/74A GB1492393A (en) 1974-02-21 1974-02-21 Cephalosporin esters

Publications (1)

Publication Number Publication Date
SE7501878L true SE7501878L (en) 1975-08-22

Family

ID=9841189

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7501878A SE7501878L (en) 1974-02-21 1975-02-19

Country Status (14)

Country Link
JP (1) JPS50121294A (en)
AU (1) AU501950B2 (en)
BE (1) BE825717A (en)
CA (1) CA1069499A (en)
CH (3) CH623589A5 (en)
DE (1) DE2507374A1 (en)
DK (1) DK57575A (en)
ES (1) ES434923A1 (en)
FR (1) FR2261773B1 (en)
GB (1) GB1492393A (en)
IL (1) IL46635A (en)
NL (1) NL7501998A (en)
PH (1) PH11815A (en)
SE (1) SE7501878L (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1130969B (en) * 1980-03-14 1986-06-18 Dob Far Spa CEFAPIRINE ESTERS, THEIR SALTS AND PROCEDURE FOR THEIR OBTAINMENT
IT1141286B (en) * 1980-04-17 1986-10-01 Dob Far Spa ESTERS OF DESACETOXY Cephalosporins THEIR SALTS AND PROCEDURES FOR THEIR OBTAINING
WO1984001949A1 (en) * 1982-11-10 1984-05-24 Kyoto Pharma Ind Cephalosporin derivatives, process and their preparation, and prophylactic and treating agent against bacterial infection

Also Published As

Publication number Publication date
JPS50121294A (en) 1975-09-23
DE2507374A1 (en) 1975-08-28
CH622801A5 (en) 1981-04-30
IL46635A0 (en) 1975-04-25
PH11815A (en) 1978-07-14
AU7837475A (en) 1976-08-19
IL46635A (en) 1978-07-31
AU501950B2 (en) 1979-07-05
FR2261773A1 (en) 1975-09-19
ES434923A1 (en) 1976-12-16
BE825717A (en) 1975-08-19
NL7501998A (en) 1975-08-25
DK57575A (en) 1975-10-20
FR2261773B1 (en) 1978-08-04
CH623329A5 (en) 1981-05-29
CH623589A5 (en) 1981-06-15
CA1069499A (en) 1980-01-08
GB1492393A (en) 1977-11-16

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