GB1250719A - - Google Patents
Info
- Publication number
- GB1250719A GB1250719A GB1452969A GB1250719DA GB1250719A GB 1250719 A GB1250719 A GB 1250719A GB 1452969 A GB1452969 A GB 1452969A GB 1250719D A GB1250719D A GB 1250719DA GB 1250719 A GB1250719 A GB 1250719A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reaction
- prepared
- formula
- acid
- followed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/023—Preparation; Separation; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1,250,719. Substituted N-benzoylpiperidene derivatives. LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB. 16 March, 1970 [19 March, 1969], No. 14529/69. Heading C2C. Novel compounds of formula wherein R 1 is a C 3-12 aliphatic hydrocarbon chain optionally attached directly or through O or S to the ring and optionally being substituted by phenyl, phenoxy or phenylthio, R 2 is alkyl and R 3 is C 5-8 cycloalkyl or R 2 and R 3 with N represents an optionally alkyl substituted heterocyclic ring, n 1 is 2 to 4, n 2 is 1 to 5 and n3 is 1 to 3, and pharmaceutically acceptable acid addition salts, are prepared by reacting a compound of Formula III with an acid halide, an anhydride, a mixed anhydride with an alkylcarbonic, carboxylic, sulphonic or inorganic acid, of an acid of Formula II or a reactive derivative thereof formed by reaction with a carbodiimide or a N,N<SP>1</SP>-carbonyldiimidazole. Intermediates of Formula II above are prepared by either diazotization of an aminobenzoic acid followed by reaction with potassium xanthogenate and an alkyl halide or by reaction of an ethyl hydroxybenzoate and an R 1 - bromide followed by hydrolysis of the ester. Piperidino alkylptperidines of Formula III above are prepared by reduction of the corresponding piperidino alkylpyridines which are prepared by reaction of 4-chloromethylpyridine or 4-vinylpyridine with the appropriate piperidine or alkylpiperidine respectively. 4 - (2 - N - Methylcyclohexylamino - ethyl)- piperidine is prepared by reaction of N-methylcyclohexylamine and 4-vinylpyridine followed by reduction. Pharmaceutical compositions in conventional forms for oral or parenteral administration and useful in treating Parkinsonism and having anticholinergic action comprise an above novel compound or salt and one or more pharmaceutical carriers therefor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1452969 | 1969-03-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1250719A true GB1250719A (en) | 1971-10-20 |
Family
ID=10042844
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1452969A Expired GB1250719A (en) | 1969-03-19 | 1969-03-19 |
Country Status (9)
Country | Link |
---|---|
US (1) | US3634410A (en) |
AT (1) | AT296306B (en) |
AU (1) | AU1212770A (en) |
BE (1) | BE747627A (en) |
DE (1) | DE2013179A1 (en) |
ES (1) | ES377734A1 (en) |
FR (1) | FR2035063A1 (en) |
GB (1) | GB1250719A (en) |
NL (1) | NL7003855A (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052311A1 (en) * | 1980-11-19 | 1982-05-26 | Sterling Drug Inc. | 1-((Benzoylphenyl) - lower-alkyl) piperidines and carbinol analogs and preparation thereof |
EP0275696A1 (en) * | 1986-12-22 | 1988-07-27 | Dr. Lo. Zambeletti S.p.A. | Piperidine derivatives |
USRE33906E (en) * | 1985-12-23 | 1992-04-28 | Dr.Lo.Zambeletti S.P.A. | Cyclic carboxamide derivatives and their use as analgesics |
WO2004085423A1 (en) * | 2003-03-25 | 2004-10-07 | Astrazeneca Ab | Piperidine derivatives for the treatment of chemokine or h1 mediated disease state |
EP1739071A1 (en) * | 2004-04-01 | 2007-01-03 | Sumitomo Chemical Company, Limited | Method for producing carboxylic acid compound |
US7186718B2 (en) | 2001-08-22 | 2007-03-06 | Astrazeneca Ab | Piperidinyl-morpholinyl derivatives as modulators of chemokine receptor activity |
US7238691B2 (en) | 2001-09-18 | 2007-07-03 | Astrazeneca Ab | Piperidine derivatives and their use as modulators of chemokine (especially CCR3) activity |
US7307090B2 (en) | 2001-07-02 | 2007-12-11 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
US7482363B2 (en) | 2002-03-19 | 2009-01-27 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
US7495013B2 (en) | 2003-04-01 | 2009-02-24 | Astrazeneca Ab | Chemical compounds |
US7517989B2 (en) | 2002-03-19 | 2009-04-14 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
US8314127B2 (en) | 2005-07-21 | 2012-11-20 | Astrazeneca Ab | Piperidine derivatives |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1585165A (en) * | 1976-06-29 | 1981-02-25 | Leo Pharm Prod Ltd | Derivatives of 6-amidino penicillanic acid |
EP0306375A1 (en) * | 1987-08-07 | 1989-03-08 | Synthelabo | 2-[(4-Piperidinyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their use in therapy |
FR2634205B2 (en) * | 1987-08-07 | 1990-09-07 | Synthelabo | ME THYL-4 ((PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEIN DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2630114B2 (en) * | 1987-08-07 | 1990-07-20 | Synthelabo | (PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2625504B2 (en) * | 1987-08-07 | 1990-05-04 | Synthelabo | ((BENZOYL-1 PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2634204B2 (en) * | 1987-08-07 | 1990-09-07 | Synthelabo | ((PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINS DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
FR2630113B2 (en) * | 1987-08-07 | 1990-07-20 | Synthelabo | ((PIPERIDINYL-4) METHYL) -2 TETRAHYDRO-1,2,3,4 ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
IL89156A (en) * | 1988-07-12 | 1993-05-13 | Synthelabo | Derivatives of 2-((4-piperidinyl) methyl)- 1,2,3,4- tetrahydroisoquinoline, their preparation and their application in therapeutics |
FR2659323B1 (en) * | 1990-03-07 | 1992-06-12 | Synthelabo | DERIVATIVES OF 4- (AMINOMETHYL) PIPERIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION. |
US5272157A (en) * | 1990-03-07 | 1993-12-21 | Synthelabo | Derivatives of 4-(aminomethyl) piperidine, their preparation and their therapeutic application |
US6152681A (en) * | 1996-05-03 | 2000-11-28 | Arrowhead Systems, Llc | Container sweep for a palletizer and method |
EP1140834A1 (en) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
-
1969
- 1969-03-19 GB GB1452969A patent/GB1250719A/en not_active Expired
-
1970
- 1970-03-04 AU AU12127/70A patent/AU1212770A/en not_active Expired
- 1970-03-06 AT AT211170A patent/AT296306B/en not_active IP Right Cessation
- 1970-03-13 US US19474A patent/US3634410A/en not_active Expired - Lifetime
- 1970-03-17 FR FR7009509A patent/FR2035063A1/fr not_active Withdrawn
- 1970-03-18 NL NL7003855A patent/NL7003855A/xx unknown
- 1970-03-19 BE BE747627D patent/BE747627A/en unknown
- 1970-03-19 DE DE19702013179 patent/DE2013179A1/en active Pending
- 1970-03-20 ES ES377734A patent/ES377734A1/en not_active Expired
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052311A1 (en) * | 1980-11-19 | 1982-05-26 | Sterling Drug Inc. | 1-((Benzoylphenyl) - lower-alkyl) piperidines and carbinol analogs and preparation thereof |
USRE33906E (en) * | 1985-12-23 | 1992-04-28 | Dr.Lo.Zambeletti S.P.A. | Cyclic carboxamide derivatives and their use as analgesics |
EP0275696A1 (en) * | 1986-12-22 | 1988-07-27 | Dr. Lo. Zambeletti S.p.A. | Piperidine derivatives |
US4879300A (en) * | 1986-12-22 | 1989-11-07 | Dr. Lo. Zambeletti S.P.A. | Novel piperidine derivatives |
US7307090B2 (en) | 2001-07-02 | 2007-12-11 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
US7186718B2 (en) | 2001-08-22 | 2007-03-06 | Astrazeneca Ab | Piperidinyl-morpholinyl derivatives as modulators of chemokine receptor activity |
US7238691B2 (en) | 2001-09-18 | 2007-07-03 | Astrazeneca Ab | Piperidine derivatives and their use as modulators of chemokine (especially CCR3) activity |
US7482363B2 (en) | 2002-03-19 | 2009-01-27 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
US7517989B2 (en) | 2002-03-19 | 2009-04-14 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
WO2004085423A1 (en) * | 2003-03-25 | 2004-10-07 | Astrazeneca Ab | Piperidine derivatives for the treatment of chemokine or h1 mediated disease state |
US7495013B2 (en) | 2003-04-01 | 2009-02-24 | Astrazeneca Ab | Chemical compounds |
EP1739071A1 (en) * | 2004-04-01 | 2007-01-03 | Sumitomo Chemical Company, Limited | Method for producing carboxylic acid compound |
EP1739071A4 (en) * | 2004-04-01 | 2008-03-26 | Sumitomo Chemical Co | Method for producing carboxylic acid compound |
US8314127B2 (en) | 2005-07-21 | 2012-11-20 | Astrazeneca Ab | Piperidine derivatives |
Also Published As
Publication number | Publication date |
---|---|
NL7003855A (en) | 1970-09-22 |
DE2013179A1 (en) | 1970-10-01 |
ES377734A1 (en) | 1972-05-16 |
AU1212770A (en) | 1971-09-09 |
AT296306B (en) | 1972-02-10 |
BE747627A (en) | 1970-08-31 |
FR2035063A1 (en) | 1970-12-18 |
US3634410A (en) | 1972-01-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PLNP | Patent lapsed through nonpayment of renewal fees |