SE521676C2 - Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet - Google Patents
Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditetInfo
- Publication number
- SE521676C2 SE521676C2 SE0200005A SE0200005A SE521676C2 SE 521676 C2 SE521676 C2 SE 521676C2 SE 0200005 A SE0200005 A SE 0200005A SE 0200005 A SE0200005 A SE 0200005A SE 521676 C2 SE521676 C2 SE 521676C2
- Authority
- SE
- Sweden
- Prior art keywords
- sulphates
- glycosaminoglycan according
- group
- heparan
- labor
- Prior art date
Links
- 229920002683 Glycosaminoglycan Polymers 0.000 title claims abstract description 29
- 208000002193 Pain Diseases 0.000 title description 8
- 230000036407 pain Effects 0.000 title description 8
- 238000011282 treatment Methods 0.000 title description 7
- 230000035935 pregnancy Effects 0.000 title description 6
- 230000002265 prevention Effects 0.000 title description 2
- 230000014508 negative regulation of coagulation Effects 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 210000003679 cervix uteri Anatomy 0.000 claims abstract description 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 6
- 210000000754 myometrium Anatomy 0.000 claims abstract description 4
- 230000000069 prophylactic effect Effects 0.000 claims abstract description 4
- 238000009109 curative therapy Methods 0.000 claims abstract description 3
- 229920002971 Heparan sulfate Polymers 0.000 claims description 30
- 229920000669 heparin Polymers 0.000 claims description 20
- 229960002897 heparin Drugs 0.000 claims description 20
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 16
- 229920000045 Dermatan sulfate Polymers 0.000 claims description 14
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 claims description 13
- 101800000989 Oxytocin Proteins 0.000 claims description 13
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 claims description 13
- 229960001723 oxytocin Drugs 0.000 claims description 13
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 11
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 8
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 6
- 230000004913 activation Effects 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 claims 1
- 230000037452 priming Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
- 238000002360 preparation method Methods 0.000 description 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 19
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 16
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical compound OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 description 12
- 102400000050 Oxytocin Human genes 0.000 description 12
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 10
- 239000002244 precipitate Substances 0.000 description 10
- 239000011780 sodium chloride Substances 0.000 description 10
- 239000002253 acid Substances 0.000 description 9
- FPJHWYCPAOPVIV-VOZMEZHOSA-N (2R,3S,4R,5R,6R)-6-[(2R,3R,4R,5R,6R)-5-acetamido-2-(hydroxymethyl)-6-methoxy-3-sulfooxyoxan-4-yl]oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical compound CO[C@@H]1O[C@H](CO)[C@H](OS(O)(=O)=O)[C@H](O[C@@H]2O[C@H]([C@@H](OC)[C@H](O)[C@H]2O)C(O)=O)[C@H]1NC(C)=O FPJHWYCPAOPVIV-VOZMEZHOSA-N 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 150000002016 disaccharides Chemical group 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000002429 anti-coagulating effect Effects 0.000 description 5
- 239000003146 anticoagulant agent Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 230000008602 contraction Effects 0.000 description 5
- 230000035800 maturation Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 238000012384 transportation and delivery Methods 0.000 description 5
- MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- 206010036872 Prolonged labour Diseases 0.000 description 4
- 239000008186 active pharmaceutical agent Substances 0.000 description 4
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 4
- 229940127219 anticoagulant drug Drugs 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 229940051593 dermatan sulfate Drugs 0.000 description 4
- 229940087051 fragmin Drugs 0.000 description 4
- 229940097043 glucuronic acid Drugs 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940011871 estrogen Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229960002442 glucosamine Drugs 0.000 description 3
- 229920002674 hyaluronan Polymers 0.000 description 3
- 229960003160 hyaluronic acid Drugs 0.000 description 3
- AEMOLEFTQBMNLQ-CLQWQSTFSA-N l-iduronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O AEMOLEFTQBMNLQ-CLQWQSTFSA-N 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000001632 sodium acetate Substances 0.000 description 3
- 235000017281 sodium acetate Nutrition 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 2
- 208000034423 Delivery Diseases 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 108010074860 Factor Xa Proteins 0.000 description 2
- 208000036365 Normal labour Diseases 0.000 description 2
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 230000002785 anti-thrombosis Effects 0.000 description 2
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N beta-D-galactopyranuronic acid Natural products OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
- 239000001639 calcium acetate Substances 0.000 description 2
- 229960005147 calcium acetate Drugs 0.000 description 2
- 235000011092 calcium acetate Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 150000008273 hexosamines Chemical class 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 239000003055 low molecular weight heparin Substances 0.000 description 2
- 229940127215 low-molecular weight heparin Drugs 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 208000033300 perinatal asphyxia Diseases 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 238000005670 sulfation reaction Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- 102000004411 Antithrombin III Human genes 0.000 description 1
- 108090000935 Antithrombin III Proteins 0.000 description 1
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 description 1
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 description 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 229920000288 Keratan sulfate Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical group CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000005107 Premature Birth Diseases 0.000 description 1
- 206010036590 Premature baby Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 239000012891 Ringer solution Substances 0.000 description 1
- 108090000054 Syndecan-2 Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002001 anti-metastasis Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229960005348 antithrombin iii Drugs 0.000 description 1
- 229940127217 antithrombotic drug Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000037020 contractile activity Effects 0.000 description 1
- 229940041967 corticotropin-releasing hormone Drugs 0.000 description 1
- KLVRDXBAMSPYKH-RKYZNNDCSA-N corticotropin-releasing hormone (human) Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)[C@@H](C)CC)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)C)C(C)C)C1=CNC=N1 KLVRDXBAMSPYKH-RKYZNNDCSA-N 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 229940018872 dalteparin sodium Drugs 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 229960002986 dinoprostone Drugs 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 150000002301 glucosamine derivatives Chemical class 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 239000002634 heparin fragment Substances 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000002184 nasal cartilage Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 201000011461 pre-eclampsia Diseases 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000019635 sulfation Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (25)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0200005A SE521676C2 (sv) | 2002-01-02 | 2002-01-02 | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| PT03700633T PT1461049E (pt) | 2002-01-02 | 2003-01-02 | Utilização de glicosaminoglicanos sulfatados para estabelecer um parto efectivo em mulheres |
| CA2472093A CA2472093C (en) | 2002-01-02 | 2003-01-02 | Use of sulfated glycosaminoglycans for establishing effective labor in women |
| IL16266403A IL162664A0 (en) | 2002-01-02 | 2003-01-02 | Use of sulfated glycosaminoglycans for establishing effective labor inwomen |
| AT03700633T ATE395067T1 (de) | 2002-01-02 | 2003-01-02 | Verwendung von sulfatierten glykosaminoglykanen zur herbeiführung von effektiven wehen bei frauen |
| DK03700633T DK1461049T3 (da) | 2002-01-02 | 2003-01-02 | Anvendelse af sulfaterede glycosaminoglykoner til etablering af effektiv födsel hos kvinder |
| ES03700633T ES2306852T3 (es) | 2002-01-02 | 2003-01-02 | Uso de glicosaminoglicanos sulfatados para establecer un parto efectivo en mujeres. |
| PL370428A PL206458B1 (pl) | 2002-01-02 | 2003-01-02 | Zastosowanie siarczanowanych glikozoaminoglikanów w położnictwie |
| KR1020047010488A KR100958691B1 (ko) | 2002-01-02 | 2003-01-02 | 임부의 효과적인 분만을 유도하기 위한 황산화글리코스아미노글리칸의 용도 |
| PCT/SE2003/000004 WO2003055499A1 (en) | 2002-01-02 | 2003-01-02 | Use of sulfated glycosaminoglycans for establishing effective labor in women |
| NZ53385603A NZ533856A (en) | 2002-01-02 | 2003-01-02 | Sulphated glycosaminoglycans with an anticoagulant activity of 100 BP units/mg or less for prophylactic priming or curative treatment of the cervix and myometrium during labour |
| US10/500,284 US7407945B2 (en) | 2002-01-02 | 2003-01-02 | Use of sulfated glycosaminoglycans for establishing effective labor in women |
| EP03700633A EP1461049B1 (en) | 2002-01-02 | 2003-01-02 | Use of sulfated glycosaminoglycans for establishing effective labor in women |
| JP2003556076A JP4434741B2 (ja) | 2002-01-02 | 2003-01-02 | 女性の有効な分娩を確立するための硫酸化グリコサミノグリカンの使用 |
| SI200331314T SI1461049T1 (sl) | 2002-01-02 | 2003-01-02 | Uporaba sulfatiranih glikozaminoglikanov za uvedbo učinkovitega poroda pri ženskah |
| AU2003201787A AU2003201787B2 (en) | 2002-01-02 | 2003-01-02 | Use of sulfated glycosaminoglycans for establishing effective labor in women |
| DE60320931T DE60320931D1 (de) | 2002-01-02 | 2003-01-02 | Verwendung von sulfatierten glykosaminoglykanen zur herbeiführung von effektiven wehen bei frauen |
| CNB038019442A CN100341518C (zh) | 2002-01-02 | 2003-01-02 | 硫酸化葡糖胺聚糖在制备预防和治疗足月分娩进展缓慢的药物制剂中的用途 |
| HK05108458.3A HK1076389B (en) | 2002-01-02 | 2003-01-02 | Use of sulfated glycosaminoglycans for the manufacture of a pharmaceutical preparation for the prevention and treatment of slow progress of term labor |
| IL162664A IL162664A (en) | 2002-01-02 | 2004-06-21 | Use of sulfated glycosaminoglycans for the manufacture of a pharmaceutical preparation for the prevention and treatment of slow progress of term labor |
| ZA2004/05015A ZA200405015B (en) | 2002-01-02 | 2004-06-24 | Use of sulfated glycosaminoglycans for establishing effective labor in women |
| NO20043190A NO332702B1 (no) | 2002-01-02 | 2004-07-27 | Anvendelse av sulfaterte glykosaminoglykaner for fremstilling av et farmasoytisk preparat for forebygging og behandling av langsom utvikling av fodselsveer hos kvinner |
| US12/168,683 US8207145B2 (en) | 2002-01-02 | 2008-07-07 | Use of sulfated glycosaminoglycans for establishing effective labor in women |
| CY20081100861T CY1108260T1 (el) | 2002-01-02 | 2008-08-13 | Χρηση θειικων γλυκοζαμινογλυκανιων για την πραγματοποιηση αποτελεσματικου τοκετου σε γυναικες |
| US13/467,918 US8524688B2 (en) | 2002-01-02 | 2012-05-09 | Use of sulfated glycosaminoglycans for establishing effective labor in women |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0200005A SE521676C2 (sv) | 2002-01-02 | 2002-01-02 | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE0200005D0 SE0200005D0 (sv) | 2002-01-02 |
| SE0200005L SE0200005L (sv) | 2003-07-03 |
| SE521676C2 true SE521676C2 (sv) | 2003-11-25 |
Family
ID=20286575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE0200005A SE521676C2 (sv) | 2002-01-02 | 2002-01-02 | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7407945B2 (pl) |
| EP (1) | EP1461049B1 (pl) |
| JP (1) | JP4434741B2 (pl) |
| KR (1) | KR100958691B1 (pl) |
| CN (1) | CN100341518C (pl) |
| AT (1) | ATE395067T1 (pl) |
| AU (1) | AU2003201787B2 (pl) |
| CA (1) | CA2472093C (pl) |
| CY (1) | CY1108260T1 (pl) |
| DE (1) | DE60320931D1 (pl) |
| DK (1) | DK1461049T3 (pl) |
| ES (1) | ES2306852T3 (pl) |
| IL (2) | IL162664A0 (pl) |
| NO (1) | NO332702B1 (pl) |
| NZ (1) | NZ533856A (pl) |
| PL (1) | PL206458B1 (pl) |
| PT (1) | PT1461049E (pl) |
| SE (1) | SE521676C2 (pl) |
| SI (1) | SI1461049T1 (pl) |
| WO (1) | WO2003055499A1 (pl) |
| ZA (1) | ZA200405015B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE521676C2 (sv) | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
| WO2005007223A2 (en) * | 2003-07-16 | 2005-01-27 | Sasha John | Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations |
| US9475888B2 (en) * | 2011-12-19 | 2016-10-25 | Dilafor Ab | Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| JP2015514705A (ja) * | 2012-03-26 | 2015-05-21 | ディラフォール・アクチボラゲットＤｉｌａｆｏｒ Ａｂ | 分娩停止の処置のための方法 |
| CA2868444A1 (en) * | 2012-03-26 | 2013-10-03 | Dilafor Ab | Combination treatment comprising sulphated glycosaminoglycans for inducing labor |
| MY192330A (en) * | 2012-05-08 | 2022-08-17 | Dilafor Ab | Treatment of postpartum haemorrhage with chemically modified heapin or heparan sulphate and a uterotonic agent |
| AU2013296240B2 (en) | 2012-08-03 | 2018-05-17 | Lfb Usa, Inc. | The use of antithrombin in extracorporeal membrane oxygenation |
| BR112022014456A2 (pt) | 2020-02-17 | 2022-09-13 | Dilafor Ab | Tafoxiparina para o tratamento da pré-eclâmpsia |
| EP4272749A1 (en) | 2022-05-03 | 2023-11-08 | Dilafor AB | New medical use of tafoxiparin |
| CN119136815A (zh) | 2022-05-03 | 2024-12-13 | 迪乐方有限责任公司 | 他福昔肝素的新医学用途 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| EP0209924A1 (en) * | 1985-07-12 | 1987-01-28 | Akzo N.V. | New anti-trombosis agent based on glycosaminoglycan, process for its preparation, and pharmaceutical compositions |
| US4916122A (en) * | 1987-01-28 | 1990-04-10 | University Of Georgia Research Foundation, Inc. | 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition |
| US5190926A (en) * | 1987-01-28 | 1993-03-02 | University Of Georgia Research Foundation, Inc. | 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents |
| SE8702254D0 (sv) | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
| GB8719367D0 (en) * | 1987-08-15 | 1987-09-23 | Wellcome Found | Therapeutic compounds |
| US5968914A (en) * | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| US5470838A (en) * | 1987-10-28 | 1995-11-28 | Pro-Neuron, Inc. | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine |
| US5736531A (en) * | 1987-10-28 | 1998-04-07 | Pro-Neuron, Inc. | Compositions of chemotherapeutic agent or antiviral agent with acylated pyrimidine nucleosides |
| US6020322A (en) * | 1993-11-09 | 2000-02-01 | Pro-Neuron, Inc. | Acyl deoxyribonucleoside derivatives and uses thereof |
| US5194654A (en) * | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
| US5411947A (en) * | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| US5543389A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization | Covalent polar lipid-peptide conjugates for use in salves |
| US5256641A (en) * | 1990-11-01 | 1993-10-26 | State Of Oregon | Covalent polar lipid-peptide conjugates for immunological targeting |
| US5543390A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5149794A (en) * | 1990-11-01 | 1992-09-22 | State Of Oregon | Covalent lipid-drug conjugates for drug targeting |
| US5280016A (en) | 1991-03-29 | 1994-01-18 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
| US5554728A (en) * | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
| SE9302135D0 (sv) * | 1993-06-18 | 1993-06-18 | Kabi Pharmacia Ab | New pharmaceutical composition |
| US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
| CA2219132C (en) * | 1995-06-07 | 2007-03-06 | Emory University | Nucleosides with anti-hepatitis b virus activity |
| US6025335A (en) * | 1995-09-21 | 2000-02-15 | Lipitek International, Inc. | L-Nucleoside Dimer Compounds and therapeutic uses |
| US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
| JP4203611B2 (ja) * | 1996-10-15 | 2009-01-07 | 生化学工業株式会社 | 子宮頸管熟化剤 |
| JP4412756B2 (ja) | 1998-02-26 | 2010-02-10 | 生化学工業株式会社 | 新規多糖誘導体、その製造法及びそれを有効成分とする医薬組成物 |
| AU4716299A (en) * | 1998-06-24 | 2000-01-10 | Emory University | Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv |
| IL127896A0 (en) * | 1998-12-31 | 1999-10-28 | Gail Laster | A novel treatment for preeclampsia and related diseases |
| JP2000309544A (ja) * | 1999-02-25 | 2000-11-07 | Seikagaku Kogyo Co Ltd | 早産または流産防止剤および子宮頚管熟化抑制剤ならびにヒアルロニダーゼの阻害剤 |
| SE521676C2 (sv) | 2002-01-02 | 2003-11-25 | Dilafor Ab | Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet |
-
2002
- 2002-01-02 SE SE0200005A patent/SE521676C2/sv unknown
-
2003
- 2003-01-02 AU AU2003201787A patent/AU2003201787B2/en not_active Ceased
- 2003-01-02 DE DE60320931T patent/DE60320931D1/de not_active Expired - Lifetime
- 2003-01-02 EP EP03700633A patent/EP1461049B1/en not_active Expired - Lifetime
- 2003-01-02 CA CA2472093A patent/CA2472093C/en not_active Expired - Fee Related
- 2003-01-02 DK DK03700633T patent/DK1461049T3/da active
- 2003-01-02 SI SI200331314T patent/SI1461049T1/sl unknown
- 2003-01-02 PL PL370428A patent/PL206458B1/pl unknown
- 2003-01-02 JP JP2003556076A patent/JP4434741B2/ja not_active Expired - Fee Related
- 2003-01-02 KR KR1020047010488A patent/KR100958691B1/ko not_active Expired - Fee Related
- 2003-01-02 WO PCT/SE2003/000004 patent/WO2003055499A1/en not_active Ceased
- 2003-01-02 AT AT03700633T patent/ATE395067T1/de active
- 2003-01-02 IL IL16266403A patent/IL162664A0/xx unknown
- 2003-01-02 ES ES03700633T patent/ES2306852T3/es not_active Expired - Lifetime
- 2003-01-02 CN CNB038019442A patent/CN100341518C/zh not_active Expired - Fee Related
- 2003-01-02 PT PT03700633T patent/PT1461049E/pt unknown
- 2003-01-02 NZ NZ53385603A patent/NZ533856A/xx not_active IP Right Cessation
- 2003-01-02 US US10/500,284 patent/US7407945B2/en not_active Expired - Fee Related
-
2004
- 2004-06-21 IL IL162664A patent/IL162664A/en not_active IP Right Cessation
- 2004-06-24 ZA ZA2004/05015A patent/ZA200405015B/en unknown
- 2004-07-27 NO NO20043190A patent/NO332702B1/no not_active IP Right Cessation
-
2008
- 2008-07-07 US US12/168,683 patent/US8207145B2/en not_active Expired - Fee Related
- 2008-08-13 CY CY20081100861T patent/CY1108260T1/el unknown
-
2012
- 2012-05-09 US US13/467,918 patent/US8524688B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8524688B2 (en) | Use of sulfated glycosaminoglycans for establishing effective labor in women | |
| JPH11504018A (ja) | 硫酸化オリゴ糖の製造および使用 | |
| CN104244957B (zh) | 用于治疗分娩停止的方法 | |
| CN104203256B (zh) | 用于引产的包含硫酸化的葡糖胺聚糖的联合治疗 | |
| AU2003242881A1 (en) | Low molecular weight oversulfated polysaccharide | |
| EP3060223B1 (en) | Sulfated polysaccharides for use in the treatment of cancer | |
| CA2868403A1 (en) | Treatment of postpartum haemorrhage with chemically modified heparin or heparan sulphate and a uterotonic agent | |
| WO2002083155A1 (en) | Use of sulfated bacterial polysaccharides suitable for the inhibition of angiogenesis | |
| HK1076389B (en) | Use of sulfated glycosaminoglycans for the manufacture of a pharmaceutical preparation for the prevention and treatment of slow progress of term labor | |
| AU2012203519A1 (en) | Treatment of cytokine mediated conditions | |
| CA2779838A1 (en) | Treatment of cytokine mediated conditions |