SE510742C2 - Closed cartridge container for receiving lyophilized preparation - Google Patents

Closed cartridge container for receiving lyophilized preparation

Info

Publication number
SE510742C2
SE510742C2 SE9103372A SE9103372A SE510742C2 SE 510742 C2 SE510742 C2 SE 510742C2 SE 9103372 A SE9103372 A SE 9103372A SE 9103372 A SE9103372 A SE 9103372A SE 510742 C2 SE510742 C2 SE 510742C2
Authority
SE
Sweden
Prior art keywords
container
lyophilized preparation
closed cartridge
cartridge container
receiving
Prior art date
Application number
SE9103372A
Other languages
Swedish (sv)
Other versions
SE9103372L (en
SE9103372D0 (en
Inventor
Heinz Redl
Thomas Seelich
Original Assignee
Immuno Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno Ag filed Critical Immuno Ag
Publication of SE9103372L publication Critical patent/SE9103372L/en
Publication of SE9103372D0 publication Critical patent/SE9103372D0/en
Publication of SE510742C2 publication Critical patent/SE510742C2/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

In a method of accelerating the dissolution of hard-soluble lyophilized medicaments based on proteins, a magnetic body 13 is introduced into an end container 6 under sterile conditions prior to the lyophilization of the batch. The end container 6 is brought into the region of a magnetic rotary field after addition of a solvent to the lyophilized batch, whereupon the magnetic body 13 is set in motion. An arrangement for carrying out the method includes a heatable block 2 of antimagnetic material with one or more accommodation openings 3, 3', 3'' etc. for the end containers. A rotating magnetic stirrer 8 is installed below the accommodation openings.

Description

15 20 25 30 35 510 742 Anordningen enligt uppfinningen innefattar standardiserade slutbehållare innehållande lyofili- serat humanprotein med vardera en stav av magne- tiserbart material, ett med åtminstone en för upptagning av standardi- serade slutbehàllare anordnad upptagningsöppning med sluten botten försett, i ett hus inneslutet upp- värmbart, i området för ett roterande magnetfält beläget block av icke-magnetiskt material. The device according to the invention comprises standardized end containers containing lyophilized human protein, each with a rod of magnetizable material, one with at least one receiving opening provided for receiving standardized end containers provided with a closed bottom, enclosed in a housing. heatable, in the area of a rotating magnetic field located block of non-magnetic material.

Det är föredraget att anordningen innefattar en i upptag- ningsöppningen insättbar insatsring, vars innerdiameter motsvarar ytterdiametern av en standardiserad slutbe- hållare. försedd med en däri insatt fasthállningsanordning för Företrädesvis är härvid insatsringens innervägg slutbehållaren.It is preferred that the device comprises an insert ring insertable in the receiving opening, the inner diameter of which corresponds to the outer diameter of a standardized final container. provided with a holding device inserted therein. Preferably, the inner wall of the insert ring is the final container.

Uppfinningen kommer i det följande att förklaras närmare med hjälp av ett exempel.The invention will be explained in more detail below by means of an example.

Ett för försegling av sår avsett vävnadsklister, ett s.k. fibrinlim, som innehåller fibrinogen och faktor XIII, fram- ställes på känt sätt, sterilfiltreras och fylles i en steriliserad slutbehàllare, i vilken dessförinnan placerats en liten stav av magnetiskt material. Därefter frystorkas det i slutbehàllaren ifyllda materialet och lagras. Då preparatet skall användas införes i slutbehàllaren sterilt, destillerat vatten medelst en injektionsspruta. Behållaren insättes i en insatsring hos den nedan beskrivna uppvärm- nings- och omrörningsanordningen, som innefattar en motor- driven roterbar permanentmagnet. Då permanentmagneten sättes i rörelse medtages den magnetiska staven av det roterande magnetfältet och försättes i rotation. Upp- 10 15 20 25 510 742 lösningen sker snabbt och utan skumbildning under sterila betingelser.A tissue adhesive intended for sealing wounds, a so-called Fibrin glue, which contains fibrinogen and factor XIII, is prepared in a known manner, sterile filtered and filled into a sterilized final container, in which a small rod of magnetic material has previously been placed. The material filled in the final container is then freeze-dried and stored. When the preparation is to be used, sterile, distilled water is introduced into the final container by means of a syringe. The container is inserted into an insert ring of the heating and stirring device described below, which comprises a motor-driven rotatable permanent magnet. When the permanent magnet is set in motion, the magnetic rod is taken by the rotating magnetic field and set in rotation. The dissolution takes place rapidly and without foaming under sterile conditions.

Uppfinningen kommer i det följande att förklaras närmare med hänvisning till pá bifogade ritning visat utförings- exempel, varvid “ fig. 1 visar ett vertikalsnitt genom anordningen och fig. 2 visar en planvy av anordningen.The invention will be explained in more detail below with reference to the exemplary embodiment shown in the accompanying drawing, in which “Fig. 1 shows a vertical section through the device and Fig. 2 shows a plan view of the device.

Den pà ritningen visade anordningen omfattar ett hus 1, i vilket är inneslutet ett uppvärmbart block 2 av icke magne- tiskt material och säkrat genom en tätningslist 1'. Blocket uppvisar en upptagningsöppning 3 med sluten botten 4, i vilken en insatsring 5 kan sättas in. Insatsringens 5 innerdiameter motsvarar ytterdiametern av en däri insatt standardiserad slutbehàllare 6 innehållande lyofiliserat proteinpreparat 12 och en stav 13 av rostfritt eller plast- överdraget ferritiskt material. Insatsringens 5 innervägg kan vara försedd med en däri insatt fasthàllningsanordning 7, lämpligen en fjäderpáverkad spärr, som förhindrar en vridning av slutbehállaren 6. Under blocket 2 är en perma- nentmagnet 8 fästad på en axel 9, som är driven av en pà ett stàngsystem ll fästad motor 10. Vid drivning av axeln 9 alstras inom upptagningsöppningen 3 och slutbehállaren 6 ett roterande magnetfält. Blocket 2 uppvärmes medelst en vârmestav 14.The device shown in the drawing comprises a housing 1, in which a heatable block 2 of non-magnetic material is enclosed and secured by a sealing strip 1 '. The block has a receiving opening 3 with a closed bottom 4, in which an insert ring 5 can be inserted. The inner diameter of the insert ring 5 corresponds to the outer diameter of a standardized final container 6 containing lyophilized protein preparation 12 and a rod 13 of stainless or plastic-coated ferritic material inserted therein. The inner wall of the insert ring 5 may be provided with a holding device 7 inserted therein, suitably a spring-actuated latch, which prevents a rotation of the end container 6. Under the block 2 a permanent magnet 8 is attached to a shaft 9, which is driven by a rod system 11 attached motor 10. When driving the shaft 9, a rotating magnetic field is generated within the receiving opening 3 and the final container 6. The block 2 is heated by means of a heating rod 14.

Claims (2)

10 15 510 742 P a t e n t k r a v10 15 510 742 P a t e n t k r a v 1. Sluten cylinderampullformig behållare för upptagande av ett frystorkat preparat under sterila betingelser, k ä n n e t e c k n a d av att i behållaren (6) också under sterila betingelser anordnats en magnetisk omrörare (13), behållaren har ett för penetrering medelst en in- jektionsspruta utførmat membran för införande av sterilt lösningsmedel och att det frystorkade preparatet är ett vävnadsklister.Closed cartridge-shaped container for receiving a lyophilised preparation under sterile conditions, characterized in that a magnetic stirrer (13) is also arranged in the container (6), the container having a membrane designed for penetration by means of a syringe for introduction of sterile solvent and that the lyophilized preparation is a tissue adhesive. 2. Behållare enligt krav 1, k ä n n e t e c k n a d av att den magnetiska omröraren (13) består av en stav av rostfritt eller plastöverdraget ferritmaterial.Container according to claim 1, characterized in that the magnetic stirrer (13) consists of a rod of stainless or plastic-coated ferrite material.
SE9103372A 1980-08-25 1991-11-14 Closed cartridge container for receiving lyophilized preparation SE510742C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0428980A AT371719B (en) 1980-08-25 1980-08-25 METHOD AND DEVICE FOR ACCELERATING THE DISOLDERING OF SLAVE-LYOPHILIZED MEDICINAL PRODUCTS

Publications (3)

Publication Number Publication Date
SE9103372L SE9103372L (en) 1991-11-14
SE9103372D0 SE9103372D0 (en) 1991-11-14
SE510742C2 true SE510742C2 (en) 1999-06-21

Family

ID=3562079

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8104544A SE8104544L (en) 1980-08-25 1981-07-24 PROCEDURE AND FINAL CONTAINER AND DEVICE FOR SPEEDING UP THE DISSOLUTION OF RESPONSIBLE LYOFILIZED MEDICINES
SE9103372A SE510742C2 (en) 1980-08-25 1991-11-14 Closed cartridge container for receiving lyophilized preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE8104544A SE8104544L (en) 1980-08-25 1981-07-24 PROCEDURE AND FINAL CONTAINER AND DEVICE FOR SPEEDING UP THE DISSOLUTION OF RESPONSIBLE LYOFILIZED MEDICINES

Country Status (14)

Country Link
JP (1) JPS5789863A (en)
AR (1) AR224086A1 (en)
AT (1) AT371719B (en)
BE (1) BE890002A (en)
CA (1) CA1182444A (en)
CH (1) CH659394A5 (en)
DE (1) DE3129995A1 (en)
DK (1) DK157331C (en)
ES (1) ES504858A0 (en)
FR (1) FR2488802A1 (en)
GB (1) GB2082929B (en)
IT (1) IT1137641B (en)
NL (1) NL189799C (en)
SE (2) SE8104544L (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3308892A1 (en) * 1983-03-12 1984-09-13 Vereinigte Aluminium-Werke AG, 1000 Berlin und 5300 Bonn HEATABLE MAGNETIC STIRRER FOR HIGH TEMPERATURE DIGESTIONS
DE3439654A1 (en) * 1984-10-30 1986-04-30 Beck & Co, 2800 Bremen Process and apparatus for uniform distribution of yeast particles in yeast-containing beer
AT382783B (en) * 1985-06-20 1987-04-10 Immuno Ag DEVICE FOR APPLICATING A TISSUE ADHESIVE
AT397203B (en) * 1988-05-31 1994-02-25 Immuno Ag FABRIC ADHESIVE
DE4017868A1 (en) * 1990-06-02 1990-10-31 Siegfried Dipl Phys Stiller Mixing chamber - for dilution and haemolysis of blood free from air bubbles
JPH06312009A (en) * 1993-04-28 1994-11-08 Daiichi Rajio Isotope Kenkyusho:Kk Radioactive medicine heating apparatus
DE4406217C2 (en) * 1994-02-25 1997-04-17 Janke & Kunkel Kg Magnetic stirrer with a housing
US5529391A (en) * 1994-09-22 1996-06-25 Duke University Magnetic stirring and heating/cooling apparatus
US5549382A (en) * 1995-04-27 1996-08-27 Correia, Ii; Bernard A. Stirrer for food preparation
DE19617369A1 (en) * 1996-04-30 1997-11-06 Immuno Ag Storage-stable fibrinogen preparations
US5899567A (en) * 1997-09-23 1999-05-04 Morris, Jr.; Joseph E. Magnetic synchronized stirring and heating test apparatus
US6382827B1 (en) * 2000-11-01 2002-05-07 Dade Behring Inc. Method and apparatus for mixing liquid solutions using a rotating magnet to generate a stirring vortex action
US6467946B1 (en) * 2001-04-24 2002-10-22 Dade Microscan Inc. Method and apparatus for mixing liquid samples in a container using rotating magnetic fields
US20030119060A1 (en) 2001-08-10 2003-06-26 Desrosiers Peter J. Apparatuses and methods for creating and testing pre-formulations and systems for same
AU2008230476B2 (en) 2007-03-22 2012-11-01 Km Biologics Co., Ltd. Solid fibrinogen preparation
MX351980B (en) 2011-12-29 2017-11-03 Omrix Biopharmaceuticals Ltd Method and device for fast dissolution of solid protein composition.
TWI590817B (en) * 2015-10-14 2017-07-11 鈺邦科技股份有限公司 Impregnation apparatus and impregnation method
CN113576756A (en) * 2021-07-15 2021-11-02 伊索曼(中山)医疗器械有限公司 Method for improving structural uniformity of freeze-dried dressing

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE498056A (en) * 1949-03-25
FR1200467A (en) * 1958-06-25 1959-12-22 Rech S Et De Controle Du Caout Stirring and thermal regulation device, particularly applicable in laboratories
GB921719A (en) * 1960-05-06 1963-03-20 Nat Res Dev Improvement in magnetic stirrers
US3356346A (en) * 1966-01-03 1967-12-05 Landsberger Kurt Test tube stirring support
CA1072538A (en) * 1975-07-03 1980-02-26 Leonard E. Brown Bottom supported magnetic stirring element
US3997272A (en) * 1975-12-15 1976-12-14 Varian Associates Magnetic stirrer improvement
SE397637B (en) * 1976-03-09 1977-11-14 Wik G MAGNETOMRORARE

Also Published As

Publication number Publication date
IT1137641B (en) 1986-09-10
DK157331C (en) 1990-05-14
CA1182444A (en) 1985-02-12
CH659394A5 (en) 1987-01-30
FR2488802A1 (en) 1982-02-26
AT371719B (en) 1983-07-25
JPS6353823B2 (en) 1988-10-25
DE3129995C2 (en) 1987-01-15
JPS5789863A (en) 1982-06-04
DK157331B (en) 1989-12-18
NL8103695A (en) 1982-03-16
SE8104544L (en) 1982-02-26
ES8303111A1 (en) 1983-02-01
BE890002A (en) 1981-12-16
NL189799C (en) 1993-08-02
DE3129995A1 (en) 1982-05-27
GB2082929B (en) 1985-02-27
DK351481A (en) 1982-02-26
ATA428980A (en) 1982-12-15
ES504858A0 (en) 1983-02-01
SE9103372L (en) 1991-11-14
GB2082929A (en) 1982-03-17
NL189799B (en) 1993-03-01
FR2488802B1 (en) 1985-01-04
AR224086A1 (en) 1981-10-15
SE9103372D0 (en) 1991-11-14
IT8123609A0 (en) 1981-08-24

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