SE501876C2 - Motorised arrangement for endoscopic removal of prostate tissue - includes tubular body, with hand grip, channels for inspection, lighting, and input for flushing fluid for removal of fluid and cut-away tissue - Google Patents

Motorised arrangement for endoscopic removal of prostate tissue - includes tubular body, with hand grip, channels for inspection, lighting, and input for flushing fluid for removal of fluid and cut-away tissue

Info

Publication number
SE501876C2
SE501876C2 SE9203375A SE9203375A SE501876C2 SE 501876 C2 SE501876 C2 SE 501876C2 SE 9203375 A SE9203375 A SE 9203375A SE 9203375 A SE9203375 A SE 9203375A SE 501876 C2 SE501876 C2 SE 501876C2
Authority
SE
Sweden
Prior art keywords
shaft
removal
motor
knife
tissue
Prior art date
Application number
SE9203375A
Other languages
Swedish (sv)
Other versions
SE9203375D0 (en
SE9203375L (en
Inventor
Christer Dahlstrand
Original Assignee
Christer Dahlstrand Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christer Dahlstrand Ab filed Critical Christer Dahlstrand Ab
Priority to SE9203375A priority Critical patent/SE501876C2/en
Publication of SE9203375D0 publication Critical patent/SE9203375D0/en
Priority to PCT/SE1994/000413 priority patent/WO1995030377A1/en
Priority to AU70106/94A priority patent/AU7010694A/en
Priority to EP94919029A priority patent/EP0774924A1/en
Publication of SE9203375L publication Critical patent/SE9203375L/en
Publication of SE501876C2 publication Critical patent/SE501876C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1485—Probes or electrodes therefor having a short rigid shaft for accessing the inner body through natural openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320016—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • A61B17/32002—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes with continuously rotating, oscillating or reciprocating cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00057—Light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00115—Electrical control of surgical instruments with audible or visual output
    • A61B2017/00119—Electrical control of surgical instruments with audible or visual output alarm; indicating an abnormal situation
    • A61B2017/00123—Electrical control of surgical instruments with audible or visual output alarm; indicating an abnormal situation and automatic shutdown
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00274—Prostate operation, e.g. prostatectomy, turp, bhp treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00547—Prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/005—Auxiliary appliance with suction drainage system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2217/00—General characteristics of surgical instruments
    • A61B2217/002—Auxiliary appliance
    • A61B2217/007—Auxiliary appliance with irrigation system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/71—Suction drainage systems
    • A61M1/77—Suction-irrigation systems
    • A61M1/774—Handpieces specially adapted for providing suction as well as irrigation, either simultaneously or independently
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/16—Male reproductive, genital organs
    • A61M2210/166—Prostate

Abstract

A shaft (6) extends through the body (1). The shaft is driven for rotation and/or oscillation by a motor at its end, so that a blade (8) fitted at the shaft other end, via a hand grip (10), is moved axially in relation to the body, imparting a rotation movement for carrying out the operative engagement. The shaft is electrically insulated from the body so that electrical current can be fed through the shaft to the blade to allow cutting and stop bleeding. A safety switch is incorporated. The shaft-driving motor (9), which can be electric, pneumatic or hydraulic, is fitted in direct connection with the tubular body or connected with it by means of a flexible shaft. An electronic safety circuit stops the motor when bleeding occurs.

Description

_501 10 15 20 25 30 35 876 2 ände anbragd kniv, som är anordnad att medelst handtaget förskjutas axiellt i förhållande till kroppen, bibringas en rotationsrörelse för genomförande av det operativa ingreppet. An end-mounted knife, which is arranged to be displaced axially relative to the body by means of the handle, is subjected to a rotational movement for carrying out the operative engagement.

Därigenom kan trots god precision den hastighet med vilken ingreppet genomföres ökas avsevärt i förhållande till tidigare känd teknik. Dessutom möjliggöres genom upp- finningen operation av mycket stora prostator, vilket ti- digare ej kunnat ske med titthålskirurgi.As a result, despite good precision, the speed at which the procedure is performed can be increased considerably in relation to the prior art. In addition, the invention enables surgery of very large prostates, which previously could not be done with peephole surgery.

Enligt ytterligare ett kännetecken på uppfinningen är axeln elektriskt isolerad från kroppen, så att elektrisk ström kan ledas genom axeln till kniven för att underlätta skärningen och stoppa blödning. Det är lämpligt att anord- na en säkerhetsbrytare för att hindra för djup skärning. Även om det i kroppen är anordnad en kanal för avlägsnande av vätska och lösskuren vävnad, kan det vara lämpligt att anordna en extra sådan kanal, företrädesvis som komplette- ring av kanalen i kroppen. Införandet av spolvätska kan ske kontinuerligt, varför inspolningsmängden kan bli för- hållandevis stor och dessutom kan urin tillföras urinblá- san och måste avlägsnas.According to a further feature of the invention, the shaft is electrically isolated from the body, so that electric current can be conducted through the shaft to the knife to facilitate cutting and stop bleeding. It is advisable to provide a safety switch to prevent excessive cutting. Although a channel is provided in the body for removing fluid and cut tissue, it may be appropriate to provide an additional such channel, preferably as a supplement to the channel in the body. The introduction of flushing fluid can take place continuously, so the amount of flushing can be relatively large and in addition urine can be supplied to the bladder and must be removed.

Vid operationen föreligger risk för blödning, vilken medför att avflödesvätskan färgas röd. Detta kan utnyttjas som varningssignal och via en elektronisk krets utnyttjas för att stoppa motorn.During the operation, there is a risk of bleeding, which causes the effluent to turn red. This can be used as a warning signal and via an electronic circuit used to stop the motor.

Uppfinningen skall i det följande närmare beskrivas med hänvisning till de bifogade ritningarna, varå fig. 1 är en perspektivvy av anordningen enligt uppfinningen.The invention will be described in more detail below with reference to the accompanying drawings, in which Fig. 1 is a perspective view of the device according to the invention.

Fig. 2 är en ändvy av kroppen till instrumentet med kniv och säkerhetsbrytare och fig. 3 är en bruten sidovy av samma del av instrumentet. Fig. 4 visar instrumentkroppen med motorn anbragt inuti denna och fig. 5 åskådliggör motorns anslutning till axeln i kroppen medelst en flexi- bel axel.Fig. 2 is an end view of the body of the instrument with knife and safety switch and Fig. 3 is a broken side view of the same part of the instrument. Fig. 4 shows the instrument body with the motor arranged inside it and Fig. 5 illustrates the connection of the motor to the shaft in the body by means of a flexible shaft.

Det i fig. l visade instrumentet för kirurgisk be- handling av företrädesvis prostata består av en kropp 1 med fyra kanaler 2, 3, 4 och 5 för inspektion, belysning, 10 15 20 25 30 35 so1.s76.å 3 inflöde av spolvätska samt för avlägsnande av vätska och lösskuren vävnad. Genom kroppen 1 sträcker sig lämpligen centralt en axel 6, som vid sin ut från änden på kroppen 1 sig sträckande änddel 7 uppbär ett skärverktyg, nämligen en kniv i form av en bygel 8. Vid sin andra ände uppbär axeln 6 enligt det i fig. 1 visade utföringsexemplet en motor 9, på vars mantel är fäst ett handtag 10. Detta operationsverktyg fungerar så, att när kroppen 1 förts in genom urinröret så långt, att kniven 8 befinner sig vid prostata, motorn 9 startas. Axeln 6 bringas då att rotera och bibringar i sin tur kniven 8 en roterande rörelse för att på så sätt skära bort ett skikt av prostatan. Med hjälp av handtaget 10 kan motorn 9 med axeln 6 och kniven 8 förskjutas på antytt sätt, varigenom vävnad avlägsnas längs hela prostatakörteln. Denna glidrörelse i hylsan innebär att skavning med hylsan mot känslig vävnad und- vikes. Skärförloppet kan under hela operationen följas genom inspektionskanalen 2 och spolning kan ske genom göras ström- av blodkärl. ett genomfö- rande av operationen på kortast möjliga tid, vilket icke blott förbättrar effektiviteten och produktiviteten för kanalerna 4 och 5. Genom att kniven lätt kan ledande, kan blödning stillas genom bränning Detta operationsinstrument möjliggör sålunda operatören utan dessutom, vilket måste anses särskilt viktigt, betyder mindre påfrestning för patienten.The instrument shown in Fig. 1 for surgical treatment of preferably the prostate consists of a body 1 with four channels 2, 3, 4 and 5 for inspection, illumination, 3 15 20 25 30 35 so1.s76.å 3 inflow of flushing fluid and for the removal of fluid and loose tissue. Extending centrally through the body 1 is a shaft 6, which at its end part 7 extending from the end of the body 1 carries a cutting tool, namely a knife in the form of a shackle 8. At its other end, the shaft 6 according to that shown in fig. 1 shows an engine 9, on the mantle of which a handle 10 is attached. This surgical tool works so that when the body 1 is inserted through the urethra so far that the knife 8 is at the prostate, the engine 9 is started. The shaft 6 is then caused to rotate and in turn imparts a rotating movement to the knife 8 in order to cut off a layer of the prostate. By means of the handle 10, the motor 9 with the shaft 6 and the knife 8 can be displaced in the indicated manner, whereby tissue is removed along the entire prostate gland. This sliding movement in the sleeve means that rubbing with the sleeve against sensitive tissue is avoided. The cutting process can be followed throughout the operation through the inspection channel 2 and flushing can take place by making a flow of blood vessels. carrying out the operation in the shortest possible time, which not only improves the efficiency and productivity of the channels 4 and 5. Because the knife can easily conduct, bleeding can be stopped by burning. means less strain on the patient.

I fig. 2 och 3 visas änddelen på kroppen 1 med kniven 8. Här åskådliggöres hur man för att hindra för djup skär- ning har anordnat en säkerhetsbrytare ll, vilken känner av om kniven 8 skulle sjunka till ett icke godtagbart djup. I sådant fall kommer änden på kroppen 1 att vara sänkt så, att bygeln ll, dvs säkerhetsbrytaren, svänges kring sin ledpunkt 12 och påverkar ett kontaktorgan 13 för att bryta strömmen till motorn 9 och sålunda avbryta skärningen av prostatan.Figures 2 and 3 show the end part of the body 1 with the knife 8. Here it is illustrated how, in order to prevent too deep cutting, a safety switch 11 has been arranged, which detects whether the knife 8 should sink to an unacceptable depth. In such a case, the end of the body 1 will be lowered so that the shackle 11, i.e. the safety switch, pivots around its pivot point 12 and acts on a contact means 13 to cut off the current to the motor 9 and thus interrupt the cutting of the prostate.

I fig. 4 visas motorn 9 anbragt i det inre av kroppen 1 och i fig. 5 àskådliggöres hur motorn 9 kan vara anbragt utanför kroppen 1 och ansluten till axeln 6 medelst en böjlig axel 14. 501 876 10 15 20 25 30 35 4 Uppfinningen är inte begränsad till de visade och beskrivna utföringsexemplen, utan många variationer är tänkbara inom ramen för de efterföljande kraven. Sålunda kan sammankopplingen av instrumentets delar ske på annat sätt än som visat med hjälp av bajonettfattningar. Ej heller är placeringen av anslutningarna för införande av ljus och spolvätska på något sätt bunden till de visade utföringsexemplen. Även andra detaljer torde kunna modi- fieras och anpassas till olika behov, eftersom det väsent- liga är att genom uppfinningen man åstadkommit ett instru- ment, som genom sin speciella konstruktion möjliggör genomförandet av en operativ behandling av prostatakörteln på en avsevärt kortare tid än som tidigare varit möjligt under för kirurgen mindre påfrestande arbete. Dessutom blir behandlingen säkrare för patienten. Det är möjligt att operera större prostata än vad som tidigare kunnat utföras med titthålskirurgi. Kniven kan även ha annan form eller storlek än vad som visas på ritningarna och be- skrives ovan. Exempelvis kan kniven vara sammansatt av från axeln utskjutande blad. Den kan även vara utbytbart anbringad på axeln.Fig. 4 shows the motor 9 arranged in the interior of the body 1 and Fig. 5 illustrates how the motor 9 can be arranged outside the body 1 and connected to the shaft 6 by means of a flexible shaft 14. 501 876 10 15 20 25 30 35 is not limited to the embodiments shown and described, but many variations are conceivable within the scope of the appended claims. Thus, the interconnection of the instrument parts can take place in another way than as shown by means of bayonet sockets. Nor is the location of the connections for the introduction of light and flushing liquid in any way bound to the embodiments shown. Other details should also be able to be modified and adapted to different needs, since it is essential that the invention provides an instrument which, through its special construction, enables the implementation of an operative treatment of the prostate gland in a considerably shorter time than previously been possible during the surgeon's less stressful work. In addition, the treatment becomes safer for the patient. It is possible to operate on a larger prostate than could previously be performed with peephole surgery. The knife can also have a different shape or size than what is shown in the drawings and described above. For example, the knife may be composed of blades projecting from the shaft. It can also be interchangeably mounted on the shaft.

Det är emellertid viktigt att kniven vid rotation är genomsiktlig. Det kan därvid också vara av betydelse vid anpassning av knivens rotationshastighet i förhållande till ljusets frekvens.However, it is important that the knife is transparent during rotation. It can also be important in adjusting the rotational speed of the knife in relation to the frequency of the light.

I stället för att roteras kontinuerligt i en riktning kan kniven roteras omväxlande i båda riktningarna delar av ett varv eller ett flertal varv i vardera riktningen.Instead of being rotated continuously in one direction, the knife can be rotated alternately in both directions parts of one revolution or several revolutions in each direction.

Tittkanalen och andra rör kan kompletteras med eller ersättas av videoteknik.The viewing channel and other tubes can be supplemented with or replaced by video technology.

Claims (8)

10 15 20 25 30 35 so1,s76. PATENTKRAV10 15 20 25 30 35 so1, s76. PATENT REQUIREMENTS 1. Anordning för motoriserat, endoskopiskt avlägs- nande av vävnad inuti en levande kropp, i synnerhet för operativ behandling av prostatakörteln, vilken anordning består av en rörformig kropp (1), som uppvisar ett handtag (10), kanaler (2, 3, 4, 5) för inspektion, videoövervak- ning, belysning, införande av spolvätska samt för avlägs- k ä av en genom kroppen (1) sig sträckande axel nande av vätska och losskuren vävnad o l, n n e - t e c k n a d (6), som är anordnad att drivas för rotation eller oscil- lation av en vid dess ena ände anbragd motor, så att en vid axelns andra ände anbragd kniv (8), som är anordnad att medelst handtaget (10) förskjutas axiellt i förhål- lande till kroppen (1), bibringas en rotationsrörelse för genomförande av det operativa ingreppet. k ä n n e t e c k - n a d därav, att axeln (6) är elektriskt isolerad frånA device for motorized, endoscopic removal of tissue within a living body, in particular for operative treatment of the prostate gland, which device consists of a tubular body (1), which has a handle (10), channels (2, 3, 4, 5) for inspection, video surveillance, lighting, insertion of flushing liquid and for removal of a shaft extending through the body (1) of liquid and loosely cut tissue etc., drawn (6), which is arranged to be driven for rotation or oscillation of a motor arranged at one end thereof, so that a knife (8) arranged at the other end of the shaft, which is arranged to be displaced axially by means of the handle (10) relative to the body (1) , a rotational movement is imparted to perform the operative intervention. characterized in that the shaft (6) is electrically insulated from 2. Anordning enligt kravet 1, kroppen (1), så att elektrisk ström kan ledas genom axeln (6) till kniven för att underlätta skärningen och stoppa blödning.Device according to claim 1, the body (1), so that electric current can be conducted through the shaft (6) to the knife to facilitate the cutting and stop bleeding. 3. Anordning enligt kravet 1 eller 2, k ä n n e - t e c k n a d av en säkerhetsbrytare (ll), som är anord- nad att hindra för djup skärning (Fig. 2).Device according to claim 1 or 2, characterized by a safety switch (ll), which is arranged to prevent too deep cutting (Fig. 2). 4. Anordning enligt något av föregående krav, k ä n n e t e c k n a d av ett en separat avloppskanal bildande rör e l som är anordnat att införas till det organ, där vävnad skall avlägsnas t ex urinblåsan, vilket rör e l är anordnat att komplettera eller ersätta avlopps- kanalen i kroppen (1).Device according to any one of the preceding claims, characterized by a tube forming a separate drainage channel which is arranged to be inserted into the organ where tissue is to be removed, for example the bladder, which tube is arranged to supplement or replace the drainage channel in the body (1). 5. Anordning enligt något av föregående krav, k ä n n e t e c k n a d därav, att den axeln (6) drivande motorn (9), som kan vara elektrisk, pneumatisk eller hydraulisk, är anbragt i eller i omedelbar anslutning till den rörformiga kroppen (1) eller förbunden med denna medelst en flexibel axel (14). 501 876 10 15 20 25 30 35 6Device according to one of the preceding claims, characterized in that the motor (9) driving the shaft (6), which may be electric, pneumatic or hydraulic, is arranged in or in immediate connection with the tubular body (1) or connected to it by means of a flexible shaft (14). 501 876 10 15 20 25 30 35 6 6. Anordning enligt något av föregående krav, k ä n n e t e c k n a d av en elektronisk säkerhetskrets, som är anordnad att stoppa motorn vid av blödning orsakad rödfärgning av flödesvätskan.Device according to one of the preceding claims, characterized by an electronic safety circuit, which is arranged to stop the motor in the event of redness of the flow liquid caused by bleeding. 7. Anordning enligt något av föregående krav, k ä n n e t e c k n a d av att kniven är utbytbart an- bragt på axeln.Device according to one of the preceding claims, characterized in that the knife is interchangeably mounted on the shaft. 8. Anordning enligt något av föregående krav, k ä n n e t e c k n a d av att kniven består av en på motorns axel anbragt skiva, från vilken knivar sträcker sig i huvudsak radiellt.Device according to one of the preceding claims, characterized in that the knife consists of a disc arranged on the shaft of the motor, from which knives extend substantially radially.
SE9203375A 1992-11-12 1992-11-12 Motorised arrangement for endoscopic removal of prostate tissue - includes tubular body, with hand grip, channels for inspection, lighting, and input for flushing fluid for removal of fluid and cut-away tissue SE501876C2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SE9203375A SE501876C2 (en) 1992-11-12 1992-11-12 Motorised arrangement for endoscopic removal of prostate tissue - includes tubular body, with hand grip, channels for inspection, lighting, and input for flushing fluid for removal of fluid and cut-away tissue
PCT/SE1994/000413 WO1995030377A1 (en) 1992-11-12 1994-05-06 A surgical instrument, particularly for operative treatment of the prostate gland
AU70106/94A AU7010694A (en) 1992-11-12 1994-05-06 A surgical instrument, particularly for operative treatment of the prostate gland
EP94919029A EP0774924A1 (en) 1992-11-12 1994-05-06 A surgical instrument, particularly for operative treatment of the prostate gland

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9203375A SE501876C2 (en) 1992-11-12 1992-11-12 Motorised arrangement for endoscopic removal of prostate tissue - includes tubular body, with hand grip, channels for inspection, lighting, and input for flushing fluid for removal of fluid and cut-away tissue
PCT/SE1994/000413 WO1995030377A1 (en) 1992-11-12 1994-05-06 A surgical instrument, particularly for operative treatment of the prostate gland

Publications (3)

Publication Number Publication Date
SE9203375D0 SE9203375D0 (en) 1992-11-12
SE9203375L SE9203375L (en) 1994-05-13
SE501876C2 true SE501876C2 (en) 1995-06-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SE9203375A SE501876C2 (en) 1992-11-12 1992-11-12 Motorised arrangement for endoscopic removal of prostate tissue - includes tubular body, with hand grip, channels for inspection, lighting, and input for flushing fluid for removal of fluid and cut-away tissue

Country Status (4)

Country Link
EP (1) EP0774924A1 (en)
AU (1) AU7010694A (en)
SE (1) SE501876C2 (en)
WO (1) WO1995030377A1 (en)

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EP0774924A1 (en) 1997-05-28
SE9203375D0 (en) 1992-11-12
SE9203375L (en) 1994-05-13
WO1995030377A1 (en) 1995-11-16
AU7010694A (en) 1995-11-29

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