SE461985B - In vitro immunisering av lymfocytinnehaallande cellpopulationer och materialsats daerfoer - Google Patents
In vitro immunisering av lymfocytinnehaallande cellpopulationer och materialsats daerfoerInfo
- Publication number
- SE461985B SE461985B SE8803208A SE8803208A SE461985B SE 461985 B SE461985 B SE 461985B SE 8803208 A SE8803208 A SE 8803208A SE 8803208 A SE8803208 A SE 8803208A SE 461985 B SE461985 B SE 461985B
- Authority
- SE
- Sweden
- Prior art keywords
- lysosomotropic
- cell populations
- vitro
- lymphocyte
- leucine
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title claims abstract description 47
- 238000002649 immunization Methods 0.000 title claims abstract description 27
- 238000000338 in vitro Methods 0.000 title claims abstract description 24
- 210000004698 lymphocyte Anatomy 0.000 title claims abstract description 19
- 230000003053 immunization Effects 0.000 title claims description 24
- 239000000463 material Substances 0.000 title claims description 6
- 239000000427 antigen Substances 0.000 claims abstract description 31
- 102000036639 antigens Human genes 0.000 claims abstract description 31
- 108091007433 antigens Proteins 0.000 claims abstract description 31
- 230000002080 lysosomotropic effect Effects 0.000 claims abstract description 30
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 23
- 239000012190 activator Substances 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 16
- 210000001541 thymus gland Anatomy 0.000 claims abstract description 16
- 230000001419 dependent effect Effects 0.000 claims abstract description 8
- 102000008072 Lymphokines Human genes 0.000 claims abstract description 3
- 108010074338 Lymphokines Proteins 0.000 claims abstract description 3
- 210000004408 hybridoma Anatomy 0.000 claims description 23
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 6
- 108090001090 Lectins Proteins 0.000 claims description 4
- 102000004856 Lectins Human genes 0.000 claims description 4
- 239000002158 endotoxin Substances 0.000 claims description 4
- 239000002523 lectin Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 241000191967 Staphylococcus aureus Species 0.000 claims description 3
- 101710120037 Toxin CcdB Proteins 0.000 claims description 3
- 150000003862 amino acid derivatives Chemical class 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 230000002411 adverse Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000470 constituent Substances 0.000 abstract 3
- 210000004989 spleen cell Anatomy 0.000 description 12
- 108010033737 Pokeweed Mitogens Proteins 0.000 description 11
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 239000012894 fetal calf serum Substances 0.000 description 3
- 230000002163 immunogen Effects 0.000 description 3
- 108010026206 Conalbumin Proteins 0.000 description 2
- 108010062580 Concanavalin A Proteins 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 210000003712 lysosome Anatomy 0.000 description 2
- 230000001868 lysosomic effect Effects 0.000 description 2
- 239000003607 modifier Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- 229930045534 Me ester-Cyclohexaneundecanoic acid Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002132 lysosomal effect Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8803208A SE461985B (sv) | 1988-09-13 | 1988-09-13 | In vitro immunisering av lymfocytinnehaallande cellpopulationer och materialsats daerfoer |
| AU42069/89A AU4206989A (en) | 1988-09-13 | 1989-09-12 | In vitro immunisation of lymphocyte-containing cell populations and kit therefor |
| PCT/SE1989/000486 WO1990002795A1 (en) | 1988-09-13 | 1989-09-12 | In vitro immunisation of lymphocyte-containing cell populations and kit therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8803208A SE461985B (sv) | 1988-09-13 | 1988-09-13 | In vitro immunisering av lymfocytinnehaallande cellpopulationer och materialsats daerfoer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8803208D0 SE8803208D0 (sv) | 1988-09-13 |
| SE8803208L SE8803208L (fa) | 1990-03-14 |
| SE461985B true SE461985B (sv) | 1990-04-23 |
Family
ID=20373301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8803208A SE461985B (sv) | 1988-09-13 | 1988-09-13 | In vitro immunisering av lymfocytinnehaallande cellpopulationer och materialsats daerfoer |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU4206989A (fa) |
| SE (1) | SE461985B (fa) |
| WO (1) | WO1990002795A1 (fa) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU645488B2 (en) * | 1989-02-21 | 1994-01-20 | Terumo Corporation | A process for the generation of proliferating CD4 lymphocytes |
| HUT62803A (en) * | 1990-05-22 | 1993-06-28 | Univ California | Process for producing antigen-specific, high affinity human monoclonal antibody |
| JP3150991B2 (ja) * | 1991-04-10 | 2001-03-26 | 協和醗酵工業株式会社 | ハイブリドーマの製造法 |
| PL2464664T3 (pl) | 2009-08-13 | 2016-02-29 | Crucell Holland Bv | Przeciwciała przeciwko ludzkiemu syncytialnemu wirusowi oddechowemu (RSV) i sposoby zastosowania |
| CN106188284B (zh) | 2010-07-09 | 2020-05-08 | 扬森疫苗与预防公司 | 抗人呼吸道合胞病毒(rsv)抗体以及使用方法 |
| US11123372B2 (en) | 2016-07-29 | 2021-09-21 | Prokidney | Bioactive renal cells for the treatment of chronic kidney disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4716111A (en) * | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| SE459008B (sv) * | 1986-09-04 | 1989-05-29 | Bioinvent Int Ab | Saett att framsstaella humana monoklonala antikroppar |
-
1988
- 1988-09-13 SE SE8803208A patent/SE461985B/sv not_active IP Right Cessation
-
1989
- 1989-09-12 AU AU42069/89A patent/AU4206989A/en not_active Abandoned
- 1989-09-12 WO PCT/SE1989/000486 patent/WO1990002795A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| SE8803208D0 (sv) | 1988-09-13 |
| WO1990002795A1 (en) | 1990-03-22 |
| SE8803208L (fa) | 1990-03-14 |
| AU4206989A (en) | 1990-04-02 |
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