SE447482B - Forfarande for framstellning av somatostatinanaloger - Google Patents
Forfarande for framstellning av somatostatinanalogerInfo
- Publication number
- SE447482B SE447482B SE7802015A SE7802015A SE447482B SE 447482 B SE447482 B SE 447482B SE 7802015 A SE7802015 A SE 7802015A SE 7802015 A SE7802015 A SE 7802015A SE 447482 B SE447482 B SE 447482B
- Authority
- SE
- Sweden
- Prior art keywords
- phe
- thr
- boc
- cys
- group
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 26
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title description 14
- 150000001875 compounds Chemical class 0.000 claims description 43
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- 125000006239 protecting group Chemical group 0.000 claims description 34
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- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 12
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 12
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77095377A | 1977-02-22 | 1977-02-22 | |
| US05/778,517 US4077952A (en) | 1977-03-17 | 1977-03-17 | Somatostatin analogs |
| US05/830,930 US4104267A (en) | 1977-02-22 | 1977-09-06 | Somatostatin analogs |
| GB4047177 | 1977-09-29 | ||
| US05/864,173 US4190575A (en) | 1977-12-27 | 1977-12-27 | Polypeptides related to somatostatin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7802015L SE7802015L (sv) | 1978-10-16 |
| SE447482B true SE447482B (sv) | 1986-11-17 |
Family
ID=27516344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7802015A SE447482B (sv) | 1977-02-22 | 1978-02-21 | Forfarande for framstellning av somatostatinanaloger |
Country Status (5)
| Country | Link |
|---|---|
| DE (1) | DE2807403A1 (da) |
| DK (1) | DK150618C (da) |
| FR (1) | FR2382433A1 (da) |
| IE (1) | IE46462B1 (da) |
| SE (1) | SE447482B (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7810156L (sv) * | 1977-12-13 | 1979-06-14 | American Home Prod | Somatostatinanaloger |
| LU80207A1 (de) * | 1978-09-07 | 1980-04-21 | H Kalbacher | Neue substituierte kohlensaeureester und urethane,verfahren zu ihrer herstellung und deren verwendung |
| US4225472A (en) * | 1979-05-29 | 1980-09-30 | American Home Products Corporation | Truncated somatostatin analogs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061608A (en) * | 1976-07-13 | 1977-12-06 | American Home Products Corporation | Arg 4 -somatostatin and analogues thereof |
-
1978
- 1978-02-17 IE IE348/78A patent/IE46462B1/en unknown
- 1978-02-21 SE SE7802015A patent/SE447482B/sv not_active IP Right Cessation
- 1978-02-21 FR FR7804954A patent/FR2382433A1/fr active Granted
- 1978-02-21 DK DK076378A patent/DK150618C/da not_active IP Right Cessation
- 1978-02-21 DE DE19782807403 patent/DE2807403A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DK150618B (da) | 1987-04-21 |
| FR2382433B1 (da) | 1983-12-09 |
| IE46462B1 (en) | 1983-06-15 |
| DK76378A (da) | 1978-08-23 |
| SE7802015L (sv) | 1978-10-16 |
| DK150618C (da) | 1987-10-19 |
| FR2382433A1 (fr) | 1978-09-29 |
| DE2807403A1 (de) | 1978-08-31 |
| DE2807403C2 (da) | 1990-11-29 |
| IE780348L (en) | 1978-08-22 |
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| Date | Code | Title | Description |
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| NUG | Patent has lapsed |
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