SE441525B - P-hydroxifenylettiksyra - Google Patents

P-hydroxifenylettiksyra

Info

Publication number
SE441525B
SE441525B SE7805275A SE7805275A SE441525B SE 441525 B SE441525 B SE 441525B SE 7805275 A SE7805275 A SE 7805275A SE 7805275 A SE7805275 A SE 7805275A SE 441525 B SE441525 B SE 441525B
Authority
SE
Sweden
Prior art keywords
chromium
acid
reduction
salt
iii
Prior art date
Application number
SE7805275A
Other languages
English (en)
Other versions
SE7805275L (sv
Inventor
P N Edwards
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd filed Critical Ici Ltd
Priority claimed from BE187882A external-priority patent/BE867289A/xx
Publication of SE7805275L publication Critical patent/SE7805275L/sv
Publication of SE441525B publication Critical patent/SE441525B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups

Description

uter. 7805275-0 2 šcm i sin eur är en värdefull mellanprcdunt för framställning av B-adrenoceptorblockeraren p-(2-hydroxi-5-isopropylamino~ propoxi)-fenylacetamid (atenolol), Uppfinningen belyses närmare med hjälp av, men är icke begränsad till nedanstående utföringsexempel.
Exemgel - 5 jEn blandning av 16,4 liter av en 65-procentig (vikt/vo- llym) kromkloridlösning och 7,5 liter 78-viktprocentig vatten- haltig svavelsyra uppvärmdes till 5500 och sattes därefter mycket snabbt till en omrörd blandning av 16,6 kg natrium- -p-hydroximandelat-monohydrat, 10,4 kg zinkpulver, 28 liter vatten och 0,35 liter paraffinolja (använd för att förhindra skumning), som uppvärmdes till 50°C. Den omrörda blandningen .uppvärmdes därefter till 80°C och ytterligare 10 liter 78- -viktprocentig svavelsyra tillsattes under loppet av 90 minu- Den omrörda blandningen uppvärmdes vid 80°C under ytter- ligare 75 minuter och filtrerades därefter. Den fasta återsto- den bestod av p-hydroxifenylättiksyra och erhölls i 97-procen- tigt utbyte, räknat på det använda natrium-p-hydroximandelatet.

Claims (4)

796527540 Patentkrav -1
1. Sätt att framställa p-hydroxifenylättiksyra, k ä n- n e t e c k n a t av reduktion av p-hydroximandelsyra med hjälp av ett krom(II)-salt.
2. Sätt enligt krav 1, k ä n n e t e c k n a t av att det kemiska reduktionsförfarandet genomföres med hjälp av ett krom(II)-salt, framställt in situ genom reduktion av ett krom- (III)-salt med zink upplöst i en syra.
3. Sätt enligt krav 2, k ä n n e t e c k n a t av att reduktionen genomföres genom användning av krom(III)klorid och zinkpulver, lästa 1 vattermaltig svavelsyra.
4. Sätt enligt ett eller flera av kraven 1-5, k ä n- n e t e c k n a t av att p-hydroximandelsyran tillföres i form av natrium-p-hydroximandelat-monohydrat. F B 87.10.” 5.000
SE7805275A 1978-05-19 1978-05-09 P-hydroxifenylettiksyra SE441525B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE187882A BE867289A (fr) 1978-05-19 1978-05-19 Procede de reduction

Publications (2)

Publication Number Publication Date
SE7805275L SE7805275L (sv) 1979-11-10
SE441525B true SE441525B (sv) 1985-10-14

Family

ID=3843116

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7805275A SE441525B (sv) 1978-05-19 1978-05-09 P-hydroxifenylettiksyra

Country Status (7)

Country Link
US (1) US4198526A (sv)
JP (1) JPS54148746A (sv)
CH (1) CH633513A5 (sv)
DE (1) DE2820854C2 (sv)
FR (1) FR2426669A1 (sv)
NL (1) NL7805438A (sv)
SE (1) SE441525B (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2944480A1 (de) * 1979-11-03 1981-05-27 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von phenylessigsaeure und von deren einfachen derivaten
JPS5699440A (en) * 1980-01-11 1981-08-10 Ube Ind Ltd Preparation of 3-alkoxy-4-hydroxyphenylacetic acid
DE3001511C2 (de) * 1980-01-17 1982-04-01 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von p-Hydroxyphenylessigsäure
US4393235A (en) * 1980-06-11 1983-07-12 Imperial Chemical Industries Plc Process for producing p-hydroxyphenyl/acetic acid
US4337355A (en) * 1980-06-20 1982-06-29 Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha Process for preparing 4-hydroxyphenylacetic acid
IN170870B (sv) * 1989-10-26 1992-06-06 Ici India Ltd
HU209251B (en) * 1992-03-13 1994-04-28 Synepos Ag Process for producing stable, peroral solution drug forms with controlled release of active ingredient and comprising beta-blocking pharmacons
FR2705669B1 (fr) * 1993-05-28 1995-08-25 Hoechst France Procédé de préparation d'acides hydroxyphénylacétiques.
CN102557917A (zh) * 2010-12-21 2012-07-11 湖北康静生物科技有限公司 一种制备2,4,6-三甲基苯乙酸的方法
CN107445823B (zh) * 2017-08-29 2020-06-09 常州沃腾化工科技有限公司 一种3，4，5-三甲氧基苯乙酸的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54125635A (en) * 1978-02-20 1979-09-29 Diamalt Ag Manufacture of 44hydroxyphenylacetic acid

Also Published As

Publication number Publication date
SE7805275L (sv) 1979-11-10
JPS54148746A (en) 1979-11-21
JPS6127381B2 (sv) 1986-06-25
FR2426669B1 (sv) 1984-01-20
DE2820854C2 (de) 1986-05-07
DE2820854A1 (de) 1979-11-22
CH633513A5 (de) 1982-12-15
US4198526A (en) 1980-04-15
FR2426669A1 (fr) 1979-12-21
NL7805438A (nl) 1979-11-21

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