SE424861B - Forfarande att framstella nya terapeutiskt aktiva derivat av guanidin innehallande en pyrrol-, pyrrolin- eller pyrrolidinrest - Google Patents
Forfarande att framstella nya terapeutiskt aktiva derivat av guanidin innehallande en pyrrol-, pyrrolin- eller pyrrolidinrestInfo
- Publication number
- SE424861B SE424861B SE7706520A SE7706520A SE424861B SE 424861 B SE424861 B SE 424861B SE 7706520 A SE7706520 A SE 7706520A SE 7706520 A SE7706520 A SE 7706520A SE 424861 B SE424861 B SE 424861B
- Authority
- SE
- Sweden
- Prior art keywords
- pyrroline
- pyrrol
- pyrrolidine
- rest
- procedure
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 2
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 title 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical class NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 title 1
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB23331/76A GB1530675A (en) | 1976-06-05 | 1976-06-05 | Guanidine derivatives |
| GB305677 | 1977-01-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7706520L SE7706520L (sv) | 1978-01-20 |
| SE424861B true SE424861B (sv) | 1982-08-16 |
Family
ID=26237989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7706520A SE424861B (sv) | 1976-06-05 | 1977-06-03 | Forfarande att framstella nya terapeutiskt aktiva derivat av guanidin innehallande en pyrrol-, pyrrolin- eller pyrrolidinrest |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4140793A (en:Method) |
| JP (1) | JPS52151161A (en:Method) |
| AU (1) | AU509883B2 (en:Method) |
| CA (1) | CA1070691A (en:Method) |
| CH (1) | CH641159A5 (en:Method) |
| CY (1) | CY1130A (en:Method) |
| DE (1) | DE2724989A1 (en:Method) |
| DK (1) | DK248177A (en:Method) |
| FR (1) | FR2353530A1 (en:Method) |
| HK (1) | HK57981A (en:Method) |
| IE (1) | IE45198B1 (en:Method) |
| KE (1) | KE3170A (en:Method) |
| MY (1) | MY8200180A (en:Method) |
| NL (1) | NL7706173A (en:Method) |
| SE (1) | SE424861B (en:Method) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1580559A (en) * | 1977-11-24 | 1980-12-03 | Wyeth John & Brother Ltd | Amide cerivatives |
| GB1588096A (en) * | 1978-05-20 | 1981-04-15 | Wyeth & Bros Ltd John | Pyrrole derivatives |
| US4332822A (en) * | 1980-02-05 | 1982-06-01 | John Wyeth & Brother Limited | Guanidine derivatives |
| FR2490026A1 (fr) * | 1980-09-09 | 1982-03-12 | Thomson Csf | Antenne reseau non dispersive et son application a la realisation d'une antenne a balayage electronique |
| US4563475A (en) * | 1984-01-13 | 1986-01-07 | William H. Rorer, Inc. | Guanidine derivatives for treating gastrointestinal motility dysfunction |
| JPH01106831U (en:Method) * | 1988-01-08 | 1989-07-19 | ||
| RU2006142552A (ru) * | 2004-06-16 | 2008-07-27 | Вайет (Us) | Производные амино-5,5-дифенилимидазолона как ингибиторы b-секретазы |
| PE20060299A1 (es) * | 2004-06-16 | 2006-05-18 | Wyeth Corp | DIFENILIMIDAZOPIRIMIDINA E -IMIDAZOL AMINAS COMO INHIBIDORES DE ß-SECRETASA |
| CA2593515A1 (en) * | 2005-01-14 | 2006-07-20 | Wyeth | Amino-imidazolones for the inhibition of beta-secretase |
| AU2006211159A1 (en) * | 2005-02-01 | 2006-08-10 | Wyeth | Amino-pyridines as inhibitors of beta-secretase |
| JP2008530103A (ja) * | 2005-02-14 | 2008-08-07 | ワイス | β−セクレターゼ阻害剤としてのアゾリルアシルグアニジン |
| TW200738683A (en) * | 2005-06-30 | 2007-10-16 | Wyeth Corp | Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation |
| WO2007005404A1 (en) * | 2005-06-30 | 2007-01-11 | Wyeth | AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION |
| TW200730523A (en) * | 2005-07-29 | 2007-08-16 | Wyeth Corp | Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation |
| CA2623245A1 (en) * | 2005-09-26 | 2007-04-05 | Wyeth | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace) |
| BRPI0620025A2 (pt) * | 2005-12-19 | 2011-10-25 | Wyeth Corp | composto, método para o tratamento de uma doença ou transtorno associado a atividade excessiva de bace, método para modular a atividade de bace, composição farmacêutica e uso do composto |
| WO2007100536A1 (en) * | 2006-02-24 | 2007-09-07 | Wyeth | DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE |
| US7700606B2 (en) * | 2006-08-17 | 2010-04-20 | Wyeth Llc | Imidazole amines as inhibitors of β-secretase |
| MX2009003102A (es) * | 2006-09-21 | 2009-04-01 | Wyeth Corp | INDOLILALQUILPIRIDIN-2-AMINAS PARA LA INHIBICION DE ß-SECRETASA. |
| PE20090160A1 (es) * | 2007-03-20 | 2009-02-11 | Wyeth Corp | COMPUESTOS AMINO-5-[4-(DIFLUOROMETOXI)FENIL SUSTITUIDO]-5-FENILIMIDAZOLONA COMO INHIBIDORES DE ß-SECRETASA |
| AR065814A1 (es) | 2007-03-23 | 2009-07-01 | Wyeth Corp | Derivados de 5-fenilimidazolona,inhibidores de beta-secretasa,composiciones farmaceuticas que los contienen y usos para prevenir y/o tratar trastornos asociados a niveles beta-amiloides elevados. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3189601A (en) * | 1964-01-10 | 1965-06-15 | Ciba Geigy Corp | N, n-alkylene-imino-lower alkanoamidine compounds |
-
1977
- 1977-05-17 IE IE1011/77A patent/IE45198B1/en unknown
- 1977-05-20 AU AU25356/77A patent/AU509883B2/en not_active Expired
- 1977-05-24 CA CA279,260A patent/CA1070691A/en not_active Expired
- 1977-05-31 US US05/801,973 patent/US4140793A/en not_active Expired - Lifetime
- 1977-06-01 CY CY1130A patent/CY1130A/xx unknown
- 1977-06-02 DE DE19772724989 patent/DE2724989A1/de not_active Withdrawn
- 1977-06-03 DK DK248177A patent/DK248177A/da not_active Application Discontinuation
- 1977-06-03 NL NL7706173A patent/NL7706173A/xx not_active Application Discontinuation
- 1977-06-03 SE SE7706520A patent/SE424861B/xx not_active IP Right Cessation
- 1977-06-03 FR FR7717042A patent/FR2353530A1/fr active Granted
- 1977-06-03 JP JP6497377A patent/JPS52151161A/ja active Granted
- 1977-06-03 CH CH688677A patent/CH641159A5/de not_active IP Right Cessation
-
1981
- 1981-11-10 KE KE3170A patent/KE3170A/xx unknown
- 1981-11-26 HK HK579/81A patent/HK57981A/xx unknown
-
1982
- 1982-12-30 MY MY180/82A patent/MY8200180A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1130A (en) | 1982-02-19 |
| IE45198B1 (en) | 1982-07-14 |
| AU509883B2 (en) | 1980-05-29 |
| KE3170A (en) | 1981-12-18 |
| NL7706173A (nl) | 1977-12-07 |
| SE7706520L (sv) | 1978-01-20 |
| JPS613332B2 (en:Method) | 1986-01-31 |
| FR2353530B1 (en:Method) | 1981-07-17 |
| DK248177A (da) | 1977-12-06 |
| IE45198L (en) | 1977-12-05 |
| CH641159A5 (de) | 1984-02-15 |
| CA1070691A (en) | 1980-01-29 |
| AU2535677A (en) | 1978-11-23 |
| DE2724989A1 (de) | 1977-12-15 |
| US4140793A (en) | 1979-02-20 |
| FR2353530A1 (fr) | 1977-12-30 |
| HK57981A (en) | 1981-12-04 |
| JPS52151161A (en) | 1977-12-15 |
| MY8200180A (en) | 1982-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 7706520-9 Effective date: 19890725 Format of ref document f/p: F |