SE337588B - - Google Patents
Info
- Publication number
- SE337588B SE337588B SE04814/67A SE481467A SE337588B SE 337588 B SE337588 B SE 337588B SE 04814/67 A SE04814/67 A SE 04814/67A SE 481467 A SE481467 A SE 481467A SE 337588 B SE337588 B SE 337588B
- Authority
- SE
- Sweden
- Prior art keywords
- hydroxy
- steroids
- estr
- ethynyl
- alpha
- Prior art date
Links
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 2
- GFPSIMORZDATOE-PNKHAZJDSA-N (8R,9S,10R,13S,14S)-13-methyl-2,4,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one Chemical compound C1C=C2CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 GFPSIMORZDATOE-PNKHAZJDSA-N 0.000 abstract 1
- JFEPJTGMGDGPHJ-PNKHAZJDSA-N (8r,9s,10r,13s,14s)-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 JFEPJTGMGDGPHJ-PNKHAZJDSA-N 0.000 abstract 1
- MSEZLHAVPJYYIQ-VMXHOPILSA-N (8s,9s,10r,13s,14s)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 MSEZLHAVPJYYIQ-VMXHOPILSA-N 0.000 abstract 1
- OXBWBKSRAIEELU-BDXSIMOUSA-N (8s,9s,13s,14s)-13-methyl-2,4,6,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C([C@H]1[C@@H]2CCC[C@]2(CC[C@@H]11)C)CC2=C1CCC(=O)C2 OXBWBKSRAIEELU-BDXSIMOUSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000004703 alkoxides Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000002084 enol ethers Chemical group 0.000 abstract 1
- HJKVPZJVBHWFCQ-BDXSIMOUSA-N estra-1,3,5(10)-trien-3-ol Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 HJKVPZJVBHWFCQ-BDXSIMOUSA-N 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
- C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
- C07C29/42—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing triple carbon-to-carbon bonds, e.g. with metal-alkynes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54081566A | 1966-04-07 | 1966-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE337588B true SE337588B (de) | 1971-08-16 |
Family
ID=24157045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE04814/67A SE337588B (de) | 1966-04-07 | 1967-04-06 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3470217A (de) |
| CH (1) | CH490358A (de) |
| DE (1) | DE1618868C3 (de) |
| DK (1) | DK122275B (de) |
| GB (1) | GB1176229A (de) |
| NL (1) | NL6704744A (de) |
| SE (1) | SE337588B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4614621A (en) * | 1984-04-20 | 1986-09-30 | The Upjohn Company | Ethynylation of 16-methylene-17-keto steroids |
| US4618456A (en) * | 1984-03-20 | 1986-10-21 | The Upjohn Company | Ethynylation of 16-methyl-17-keto steroids |
| ES2576231T3 (es) | 2011-12-23 | 2016-07-06 | Crystal Pharma S.A.U | Proceso para alquinilar 17-cetoesteroides 16-sustituidos |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2806030A (en) * | 1954-03-20 | 1957-09-10 | Syntex Sa | Cyclopentanophenanthrene derivatives and process for the preparation thereof |
| US2888471A (en) * | 1955-03-25 | 1959-05-26 | Syntex Sa | Process for preparing 17alpha-ethinyl-delta1, 4-androstadiene-17 beta-ol-3-one |
| NL123455C (de) * | 1964-05-13 |
-
1966
- 1966-04-07 US US540815A patent/US3470217A/en not_active Expired - Lifetime
-
1967
- 1967-03-31 DK DK187367AA patent/DK122275B/da unknown
- 1967-04-04 GB GB05411/67A patent/GB1176229A/en not_active Expired
- 1967-04-04 NL NL6704744A patent/NL6704744A/xx unknown
- 1967-04-06 SE SE04814/67A patent/SE337588B/xx unknown
- 1967-04-06 DE DE1618868A patent/DE1618868C3/de not_active Expired
- 1967-04-07 CH CH495267A patent/CH490358A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE1618868A1 (de) | 1972-07-06 |
| DK122275B (da) | 1972-02-14 |
| DE1618868C3 (de) | 1973-10-11 |
| CH490358A (de) | 1970-05-15 |
| GB1176229A (en) | 1970-01-01 |
| US3470217A (en) | 1969-09-30 |
| NL6704744A (de) | 1967-10-09 |
| DE1618868B2 (de) | 1973-03-08 |
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