SE334357B - - Google Patents

Info

Publication number
SE334357B
SE334357B SE1167966A SE1167966A SE334357B SE 334357 B SE334357 B SE 334357B SE 1167966 A SE1167966 A SE 1167966A SE 1167966 A SE1167966 A SE 1167966A SE 334357 B SE334357 B SE 334357B
Authority
SE
Sweden
Prior art keywords
acid
trihaloacetoxy
pregnane series
lower alkanoyloxy
solvolysed
Prior art date
Application number
SE1167966A
Inventor
E Shapiro
L Finckenor
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of SE334357B publication Critical patent/SE334357B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

11b -Hydroxy-17a -lower alkanoyloxy esters of the pregnane series are obtained by treating an 11b -trihaloacetoxy-17a -lower alkanoyloxy ester of the pregnane series in a lower alkanol with a salt of an acid having a pKa falling within the range of about 2.3 and about 7.3 whereby the 11b -trihaloacetoxy grouping is selectively solvolysed to a free hydroxy group. Suitable salts are the sodium or potassium salts of hydrazoic acid, formic acid or trifluoroacetic acid. Pharmaceutical compositions having anti-inflammatory activity and containing the above compounds are administered topically.
SE1167966A 1965-08-30 1966-08-30 SE334357B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48381065A 1965-08-30 1965-08-30

Publications (1)

Publication Number Publication Date
SE334357B true SE334357B (en) 1971-04-26

Family

ID=23921623

Family Applications (1)

Application Number Title Priority Date Filing Date
SE1167966A SE334357B (en) 1965-08-30 1966-08-30

Country Status (7)

Country Link
BE (1) BE686189A (en)
CH (1) CH481085A (en)
DE (1) DE1593519B2 (en)
DK (1) DK117350B (en)
ES (1) ES330696A1 (en)
GB (1) GB1097164A (en)
SE (1) SE334357B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK153556C (en) * 1974-03-27 1988-12-05 Plurichemie Anstalt METHOD FOR PREPARING ESTERS OF 9ALFA-CHLORINE-OR-FLUORO-16ALFA- OR -16-BETA-METHYL-21-DESOXYPREDNISOLONES
IL66432A0 (en) * 1981-08-04 1982-12-31 Plurichemie Anstalt Process for the preparation of steroidal esters

Also Published As

Publication number Publication date
CH481085A (en) 1969-11-15
BE686189A (en) 1967-02-28
DE1593519B2 (en) 1975-08-14
DK117350B (en) 1970-04-20
DE1593519A1 (en) 1970-09-03
ES330696A1 (en) 1967-06-16
GB1097164A (en) 1967-12-29

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