GB1097164A - Selective solvolysis of 11ª‰,17ª‡,21-triesters of the pregnane series - Google Patents

Selective solvolysis of 11ª‰,17ª‡,21-triesters of the pregnane series

Info

Publication number
GB1097164A
GB1097164A GB3866066A GB3866066A GB1097164A GB 1097164 A GB1097164 A GB 1097164A GB 3866066 A GB3866066 A GB 3866066A GB 3866066 A GB3866066 A GB 3866066A GB 1097164 A GB1097164 A GB 1097164A
Authority
GB
United Kingdom
Prior art keywords
pregnane series
acid
triesters
trihaloacetoxy
lower alkanoyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3866066A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of GB1097164A publication Critical patent/GB1097164A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

11b -Hydroxy-17a -lower alkanoyloxy esters of the pregnane series are obtained by treating an 11b -trihaloacetoxy-17a -lower alkanoyloxy ester of the pregnane series in a lower alkanol with a salt of an acid having a pKa falling within the range of about 2.3 and about 7.3 whereby the 11b -trihaloacetoxy grouping is selectively solvolysed to a free hydroxy group. Suitable salts are the sodium or potassium salts of hydrazoic acid, formic acid or trifluoroacetic acid. Pharmaceutical compositions having anti-inflammatory activity and containing the above compounds are administered topically.
GB3866066A 1965-08-30 1966-08-30 Selective solvolysis of 11ª‰,17ª‡,21-triesters of the pregnane series Expired GB1097164A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48381065A 1965-08-30 1965-08-30

Publications (1)

Publication Number Publication Date
GB1097164A true GB1097164A (en) 1967-12-29

Family

ID=23921623

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3866066A Expired GB1097164A (en) 1965-08-30 1966-08-30 Selective solvolysis of 11ª‰,17ª‡,21-triesters of the pregnane series

Country Status (7)

Country Link
BE (1) BE686189A (en)
CH (1) CH481085A (en)
DE (1) DE1593519B2 (en)
DK (1) DK117350B (en)
ES (1) ES330696A1 (en)
GB (1) GB1097164A (en)
SE (1) SE334357B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072200A2 (en) * 1981-08-04 1983-02-16 Plurichemie Anstalt Steroidal esters and process for the preparation of steroidal esters

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH622811A5 (en) * 1974-03-27 1981-04-30 Plurichemie Anstalt

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072200A2 (en) * 1981-08-04 1983-02-16 Plurichemie Anstalt Steroidal esters and process for the preparation of steroidal esters
EP0072200A3 (en) * 1981-08-04 1983-06-01 Plurichemie Anstalt Steroidal esters and process for the preparation of steroidal esters

Also Published As

Publication number Publication date
CH481085A (en) 1969-11-15
BE686189A (en) 1967-02-28
DK117350B (en) 1970-04-20
SE334357B (en) 1971-04-26
ES330696A1 (en) 1967-06-16
DE1593519B2 (en) 1975-08-14
DE1593519A1 (en) 1970-09-03

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