SE327779B - - Google Patents

Info

Publication number
SE327779B
SE327779B SE04365/62A SE436562A SE327779B SE 327779 B SE327779 B SE 327779B SE 04365/62 A SE04365/62 A SE 04365/62A SE 436562 A SE436562 A SE 436562A SE 327779 B SE327779 B SE 327779B
Authority
SE
Sweden
Prior art keywords
amino
plasmin
acid
amino acid
millimole
Prior art date
Application number
SE04365/62A
Inventor
V Jensen
Original Assignee
Novo Terapeutisk Labor As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Terapeutisk Labor As filed Critical Novo Terapeutisk Labor As
Publication of SE327779B publication Critical patent/SE327779B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

A plasmin preparation for therapeutic use comprises plasmin and, as stabilizer and solubilizer therefor, 0.002 millimole to 1 millimole of amino acid per unit of plasmin. The amino acid may be an aliphatic amino monocarboxylic acid, preferably an amino acid having at least one amino group bound to a carbon atom which is separated from the carboxylic group or groups by at least one carbon atom, or it may be a dipeplide such as glycyl glycine and leucyl glycine. Typical amino acids are lysine, e -aminocaproic acid, L-arginine, g -aminobutyric acid, ornithine and a -N-acetyl-L-arginine.ALSO:A plasmin preparation for therapeutic use comprises plasmin and, as stabilizer and solubilizer therefor, 0,002 millimole to 1 millimole of amino acid per unit of plasmin. The amino acid may be an aliphatic amino-monocarboxylic acid and it is preferred that the amino acid is one having at least one amino group bound to a carbon atom which is separated from the carboxylic group or groups by at least one carbon atom; it may also be a dipeptide. Typical, amino acids are lysine, e -amino-caproic acid, L-arginine, g -aminobutyric acid, ornithine, glycyl glycine and leucyl glycine. The plasmin may be dissolved in an aqueous injectable liquid at pH 2 to 3, the amino acid added, the pH adjusted to 7, the mixture filtered and freeze dried.
SE04365/62A 1961-04-25 1962-04-18 SE327779B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK169161AA DK98833C (en) 1961-04-25 1961-04-25 Method for stabilizing therapeutically useful plasmin solutions.

Publications (1)

Publication Number Publication Date
SE327779B true SE327779B (en) 1970-08-31

Family

ID=8107240

Family Applications (1)

Application Number Title Priority Date Filing Date
SE04365/62A SE327779B (en) 1961-04-25 1962-04-18

Country Status (9)

Country Link
BE (1) BE616779A (en)
CH (1) CH456848A (en)
DK (1) DK98833C (en)
FI (1) FI43764B (en)
FR (1) FR2140M (en)
GB (1) GB985498A (en)
NL (1) NL147634B (en)
NO (1) NO123024B (en)
SE (1) SE327779B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2750159C3 (en) * 1977-11-09 1980-05-22 Lentia Gmbh, Chem. U. Pharm. Erzeugnisse - Industriebedarf, 8000 Muenchen Infusion solution for the treatment of hepatic encephalopathy and a process for the manufacture thereof
JPH0672105B2 (en) * 1985-10-02 1994-09-14 持田製薬株式会社 Thrombolytic agent and manufacturing method thereof
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US6355243B1 (en) † 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
EP1545588A4 (en) * 2002-07-23 2007-12-05 Ludwig Inst Cancer Res Methods and compositions for activating or inhibiting vegf-d and vegf-c
GB0228409D0 (en) 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
US20060257391A1 (en) * 2005-05-11 2006-11-16 Bausch & Lomb Incorporated Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions
BRPI0913397B8 (en) 2008-06-04 2021-05-25 Grifols Therapeutics Inc method for preparing plasmin
JP5789521B2 (en) 2009-03-03 2015-10-07 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Compositions, methods and kits for producing plasminogen; and plasmin produced therefrom
CN106167797B (en) * 2016-07-28 2019-04-09 国药集团武汉血液制品有限公司 The lyophilized preparation and preparation method thereof of human fibrin dissolution proenzyme

Also Published As

Publication number Publication date
CH456848A (en) 1968-05-31
FR2140M (en) 1963-11-12
GB985498A (en) 1965-03-10
NO123024B (en) 1971-09-20
DK98833C (en) 1964-05-25
FI43764B (en) 1971-03-01
BE616779A (en) 1962-10-24
NL147634B (en) 1975-11-17

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