SA118390677B1 - مشتقات ثنائي هيدرو بيريميدينون - Google Patents

مشتقات ثنائي هيدرو بيريميدينون

Info

Publication number
SA118390677B1
SA118390677B1 SA118390677A SA118390677A SA118390677B1 SA 118390677 B1 SA118390677 B1 SA 118390677B1 SA 118390677 A SA118390677 A SA 118390677A SA 118390677 A SA118390677 A SA 118390677A SA 118390677 B1 SA118390677 B1 SA 118390677B1
Authority
SA
Saudi Arabia
Prior art keywords
heteroaryl
treating
pharmaceutical composition
substituted
making
Prior art date
Application number
SA118390677A
Other languages
English (en)
Inventor
محمد عبدالرحمن العمر د.
معشوق أحمد بهات د.
Original Assignee
جامعة الملك سعود
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by جامعة الملك سعود filed Critical جامعة الملك سعود
Publication of SA118390677B1 publication Critical patent/SA118390677B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D227/00—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00
    • C07D227/02—Heterocyclic compounds containing rings having one nitrogen atom as the only ring hetero atom, according to more than one of groups C07D203/00 - C07D225/00 with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

يضم مشتق ثنائي هيدرو بيريميدينون A dihydropyrirnidinone derivative مركب لديه تركيب كيميائي طبقاً للصيغة 1: (الصيغة 1) حيث يتم إختيار Z من CH2، O، وN؛ يتم إختيار X من O وS ؛ و R تمثل أريل aryl أو أريل مستبدل substituted aryl أو أريل مخلط heteroaryl أو أريل مخلط مستبدل substituted heteroaryl، حيث الأريل مستبدل substituted aryl أو أريل مخلط مستبدل substituted heteroaryl لديه واحد أو أكثر من البدائل المُختارة من المجموعة المكونة من الهالوجين halogen، ألكيل، هالو ألكيل haloalkyl، ألكوكسي alkoxy، هالو ألكوكسي haloalkoxy، نيترو nitro، هيدروكسيل hydroxyl، ألكيل ثيو alkylthio، ألكيل أمينو alkylarnino ، أريل مخلط heteroaryl ، أريلوكسي aryloxy، هالو أريلوكسي haloaryloxy ، أريل ثيو arylthio ، أريل أمينو arylamino وأملاح مقبولة صيدلانياً منهم. ترتبط مادة الموضوع الحالي أيضاً بطريقة لصنع مشتقات ثنائي هيدرو بيريميدينون dihydropyrirnidinone derivative، طريقة لعلاج مرض بالجهاز الهضمي، طريقة لعلاج قرحة treating an ulcer، تركيب صيدلاني a pharrnaceutical composition، وطريقة لصنع تركيب صيدلاني.
SA118390677A 2017-06-20 2018-06-07 مشتقات ثنائي هيدرو بيريميدينون SA118390677B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15/628,476 US9856232B1 (en) 2017-06-20 2017-06-20 Dihydropyrimidinone derivatives

Publications (1)

Publication Number Publication Date
SA118390677B1 true SA118390677B1 (ar) 2021-06-09

Family

ID=60805043

Family Applications (1)

Application Number Title Priority Date Filing Date
SA118390677A SA118390677B1 (ar) 2017-06-20 2018-06-07 مشتقات ثنائي هيدرو بيريميدينون

Country Status (2)

Country Link
US (1) US9856232B1 (ar)
SA (1) SA118390677B1 (ar)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10047071B1 (en) 2018-01-15 2018-08-14 King Saud University Dihydropyrimidinone derivatives
US10111873B1 (en) 2018-01-17 2018-10-30 King Saud University Dihydropyrimidinone derivatives
US10358425B1 (en) * 2018-09-04 2019-07-23 King Abdulaziz Universkty Dihydropyrimidones and pharmaceutical compositions thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU733883B2 (en) 1997-02-04 2001-05-31 Bristol-Myers Squibb Company Dihydropyrimidone derivatives as NPY antagonists
KR20050042190A (ko) 2002-09-10 2005-05-04 바이엘 헬스케어 아게 급성 및 만성 염증성, 허혈성 및 재형성 과정에 대한 치료제로서의 피리미디논 유도체
SI2234985T1 (sl) 2007-12-20 2012-06-29 Bayer Pharma AG 4-(4-ciano-2-tioaril)dihidropirimidinoni in njihova uporaba
CN103724339B (zh) * 2012-09-27 2015-10-14 广东东阳光药业有限公司 二氢嘧啶衍生物的晶型
US9115093B2 (en) 2013-03-04 2015-08-25 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9458113B2 (en) 2014-07-31 2016-10-04 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity
US9440930B2 (en) 2014-07-31 2016-09-13 Boehringer Ingelheim International Gmbh Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity

Also Published As

Publication number Publication date
US9856232B1 (en) 2018-01-02

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