RU99102852A - DERIVATIVES 11-ACETYL-12,13-DIOXABICYCLO [8.2.1] TRIDECENONE, METHOD FOR PRODUCING THEM AND CONTAINING THESE COMPOUNDS MEDICINES - Google Patents
DERIVATIVES 11-ACETYL-12,13-DIOXABICYCLO [8.2.1] TRIDECENONE, METHOD FOR PRODUCING THEM AND CONTAINING THESE COMPOUNDS MEDICINESInfo
- Publication number
- RU99102852A RU99102852A RU99102852/04A RU99102852A RU99102852A RU 99102852 A RU99102852 A RU 99102852A RU 99102852/04 A RU99102852/04 A RU 99102852/04A RU 99102852 A RU99102852 A RU 99102852A RU 99102852 A RU99102852 A RU 99102852A
- Authority
- RU
- Russia
- Prior art keywords
- methyl
- hydrogen
- compound
- acetyl
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 9
- 239000003814 drug Substances 0.000 title claims 2
- BDASTSZOTDZESK-UHFFFAOYSA-N 12-acetyl-11,13-dioxabicyclo[8.2.1]tridec-7-en-9-one Chemical compound O1C2C(C(=O)C)OC1C(=O)C=CCCCCC2 BDASTSZOTDZESK-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 230000002378 acidificating Effects 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 238000007248 oxidative elimination reaction Methods 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
Claims (5)
где R1 обозначает водород или метил и
R2 обозначает водород или низший алканоил
и их физиологически приемлемые кислые аддитивные соли.1. Derivatives (2R, 3S, 4S, 5R, 6R, 10R, 11R) -2,4,6,8,10-pentamethyl-11-acetyl-12,13-dioxabicyclo [8.2.1] tridets-8-ene -1-she of the general formula I
where R 1 denotes hydrogen or methyl and
R 2 is hydrogen or lower alkanoyl
and their physiologically acceptable acid addition salts.
где R1 обозначает водород или метил и
R2 обозначает водород или низший алканоил
и их физиологически приемлемых кислых аддитивных солей, отличающийся тем, что в соединении общей формулы II,
где R1 и R2 имеют вышеуказанные значения, 2',3'-дигидроксипент-2'-ильную боковую цепь в 11-положении циклической основной структуры переводят путем окислительного расщепления гликоля в боковую ацетильную цепь, и, в случае необходимости, в полученное соединение формулы I, где R1 обозначает водород, вводят метильный остаток R1 или в полученном соединении формулы I, где R1 обозначает метил, отщепляют метильный остаток R1, и, в случае необходимости, свободные соединения формулы I переводят в их стабильные кислые аддитивные соли или кислые аддитивные соли переводят в свободные соединения формулы I.5. A method of obtaining derivatives of (2R, 3S, 4S, 5R, 6R, 10R, 11P) -2,4,6,8,10-pentamethyl-11-acetyl-12,13-dioxabicyclo- [8.2.1] -tride -8-en-1-one of general formula I,
where R 1 denotes hydrogen or methyl and
R 2 is hydrogen or lower alkanoyl
and their physiologically acceptable acid addition salts, characterized in that in the compound of General formula II,
where R 1 and R 2 have the above meanings, the 2 ′, 3′-dihydroxypent-2′-yl side chain at the 11-position of the cyclic main structure is converted by oxidative cleavage of the glycol to the side acetyl chain, and, if necessary, to the obtained compound of the formula I, where R 1 is hydrogen, a methyl residue R 1 is introduced, or in the resulting compound of the formula I, where R 1 is methyl, the methyl residue R 1 is cleaved and, if necessary, the free compounds of the formula I are converted into their stable acid addition salts or acidic additive oli converted into the free compounds of formula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19805822.5 | 1998-02-13 | ||
DE19805822A DE19805822B4 (en) | 1998-02-13 | 1998-02-13 | 11-Acetyl-12,13-dioxabicyclo [8.2.1] tridecenone derivatives, process for their preparation and medicaments containing these compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
RU99102852A true RU99102852A (en) | 2000-12-20 |
RU2218346C2 RU2218346C2 (en) | 2003-12-10 |
Family
ID=7857548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU99102852/04A RU2218346C2 (en) | 1998-02-13 | 1999-02-12 | Derivatives of 11-acetyl-12,13-dioxabicyclo[8,2,1]- tridecenone, method for their preparing and medicinal agent comprising these compounds |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0937734B1 (en) |
JP (1) | JPH11269193A (en) |
KR (1) | KR100584017B1 (en) |
CN (1) | CN1189473C (en) |
AR (1) | AR014320A1 (en) |
AT (1) | ATE486083T1 (en) |
AU (1) | AU748670B2 (en) |
BR (1) | BR9900442A (en) |
CA (1) | CA2260315C (en) |
CZ (1) | CZ294879B6 (en) |
DE (2) | DE19805822B4 (en) |
DZ (1) | DZ2721A1 (en) |
ES (1) | ES2355187T3 (en) |
HK (1) | HK1023575A1 (en) |
HU (1) | HU222539B1 (en) |
ID (1) | ID21968A (en) |
IL (1) | IL128238A (en) |
NO (1) | NO310917B1 (en) |
NZ (1) | NZ334087A (en) |
PL (1) | PL192281B1 (en) |
RU (1) | RU2218346C2 (en) |
SK (1) | SK285313B6 (en) |
TR (1) | TR199900285A3 (en) |
TW (1) | TW579379B (en) |
UA (1) | UA57030C2 (en) |
ZA (1) | ZA99678B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60027015T2 (en) * | 2000-08-17 | 2006-10-05 | The Kitasato Institute | Pseudoerythromycin DERIVATIVES |
GB0611907D0 (en) | 2006-06-15 | 2006-07-26 | Glaxo Group Ltd | Compounds |
JP2009501199A (en) | 2005-07-12 | 2009-01-15 | グラクソ グループ リミテッド | Piperazine heteroaryl derivatives as GPR38 agonists |
NZ565062A (en) | 2005-07-26 | 2011-02-25 | Glaxo Group Ltd | Benzylpiperazine derivates and their use in treating conditions mediated by GPR38 receptors |
ES2344484T3 (en) | 2006-06-28 | 2010-08-27 | Glaxo Group Limited | PIPERAZINYL DERIVATIVES USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY THE GPR38 RECEIVER |
CA2750699C (en) | 2009-02-27 | 2015-12-29 | Raqualia Pharma Inc. | Oxyindole derivatives with motilin receptor agonistic activity |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5106961A (en) * | 1987-05-26 | 1992-04-21 | Eli Lilly And Company | Erythromycin ring-contracted derivatives |
US4920102A (en) * | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
NZ232375A (en) * | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
DE4200145A1 (en) * | 1992-01-07 | 1993-07-08 | Kali Chemie Pharma Gmbh | 7,10-EPOXY-OXACYCLODODANE DERIVATIVES, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS |
US5712253A (en) * | 1996-06-18 | 1998-01-27 | Abbott Laboratories | Macrocyclic 13-membered ring derivatives of erythromycins A and B |
-
1998
- 1998-02-13 DE DE19805822A patent/DE19805822B4/en not_active Expired - Fee Related
-
1999
- 1999-01-15 AR ARP990100149A patent/AR014320A1/en not_active Application Discontinuation
- 1999-01-25 CA CA002260315A patent/CA2260315C/en not_active Expired - Fee Related
- 1999-01-26 IL IL12823899A patent/IL128238A/en unknown
- 1999-01-27 TW TW088101211A patent/TW579379B/en not_active IP Right Cessation
- 1999-01-28 ZA ZA9900678A patent/ZA99678B/en unknown
- 1999-02-01 KR KR1019990003207A patent/KR100584017B1/en not_active IP Right Cessation
- 1999-02-05 HU HU9900263A patent/HU222539B1/en not_active IP Right Cessation
- 1999-02-05 SK SK150-99A patent/SK285313B6/en unknown
- 1999-02-08 EP EP99101675A patent/EP0937734B1/en not_active Expired - Lifetime
- 1999-02-08 DE DE59915209T patent/DE59915209D1/en not_active Expired - Lifetime
- 1999-02-08 ES ES99101675T patent/ES2355187T3/en not_active Expired - Lifetime
- 1999-02-08 AT AT99101675T patent/ATE486083T1/en active
- 1999-02-08 NZ NZ334087A patent/NZ334087A/en unknown
- 1999-02-10 DZ DZ990022A patent/DZ2721A1/en active
- 1999-02-10 BR BR9900442-9A patent/BR9900442A/en not_active Application Discontinuation
- 1999-02-10 JP JP11032750A patent/JPH11269193A/en active Pending
- 1999-02-10 CZ CZ1999458A patent/CZ294879B6/en not_active IP Right Cessation
- 1999-02-10 TR TR1999/00285A patent/TR199900285A3/en unknown
- 1999-02-11 UA UA99020798A patent/UA57030C2/en unknown
- 1999-02-11 CN CNB991021266A patent/CN1189473C/en not_active Expired - Fee Related
- 1999-02-12 RU RU99102852/04A patent/RU2218346C2/en not_active IP Right Cessation
- 1999-02-12 NO NO19990675A patent/NO310917B1/en unknown
- 1999-02-12 PL PL331444A patent/PL192281B1/en unknown
- 1999-02-12 ID IDP990111D patent/ID21968A/en unknown
- 1999-02-12 AU AU16438/99A patent/AU748670B2/en not_active Ceased
-
2000
- 2000-04-28 HK HK00102579A patent/HK1023575A1/en not_active IP Right Cessation
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