RU2001124604A - Hypertension Medication - Google Patents

Claims (6)

1. The use of compounds of General formula I

where R ¹ denotes a phenyl (C ₁ -C ₄ ) alkyl group, which, if necessary, can be substituted on the phenyl ring by (C ₁ -C ₄ ) alkyl, (C ₁ -C ₄ ) alkoxy or halogen, or naphthyl (C ₁ - C ₄ ) an alkyl group, R ² is hydrogen or a biolabile ester forming group, and R ³ denotes hydrogen or a group forming a biolabile ester, and physiologically acceptable acid salts of formula I for the preparation of pharmaceutical compositions for the treatment of symptomatic forms of hypertension, especially those forms of symptomatic hypertension that are not caused by heart disease, in large mammals and humans. 2. The use of compounds according to claim 1, characterized in that symptomatic hypertension, which is not caused by heart disease, is pulmonary hypertension. 3. The use of compounds according to claim 1 or 2, where R ² and / or R ³ denote groups forming a biolabile ester. 4. The use of compounds according to any one of the preceding paragraphs, wherein the biolabile ester forming group is a C ₁ -C ₄ alkyl group, a phenyl or phenyl C ₁ -C ₄ alkyl group, especially phenyl, benzyl or indanyl, optionally substituted on the phenyl ring C ₁ -C ₄ alkyl or C ₁ -C ₄ alkylene chain linking two adjacent carbon atoms, a dioxolanylmethyl group, optionally substituted on the dioxolane ring with C ₁ -C ₄ alkyl, especially (2,2-dimethyl-1 , 3-dioxolan-4-yl) methyl group, or C ₁ -C ₄ alkanoyloxime an ethyl group optionally substituted on the hydroxymethyl group by C ₁ -C ₄ alkyl. 5. The use of compounds according to any one of the preceding paragraphs, characterized in that R ² denotes a group forming a biolabile ester, and R ³ denotes hydrogen. 6. The use of compounds according to claim 1, characterized in that the use of (3S, 2'R) -3- {1- [2 '- (ethoxycarbonyl) -4'-phenylbutyl] cyclopentane-1-carbonylamino} -2,3 , 4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid or its physiologically acceptable salts.