RU96109699A - GUANIDIDES OF ALKENILKARBONIC ACIDS, METHOD OF THEIR RECEIVING, CONTAINING THEIR MEDICATION OR DIAGNOSTIC TOOL - Google Patents

GUANIDIDES OF ALKENILKARBONIC ACIDS, METHOD OF THEIR RECEIVING, CONTAINING THEIR MEDICATION OR DIAGNOSTIC TOOL

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Publication number
RU96109699A
RU96109699A RU96109699/04A RU96109699A RU96109699A RU 96109699 A RU96109699 A RU 96109699A RU 96109699/04 A RU96109699/04 A RU 96109699/04A RU 96109699 A RU96109699 A RU 96109699A RU 96109699 A RU96109699 A RU 96109699A
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RU
Russia
Prior art keywords
hydrogen
formula
compound
residues
alkyl
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Application number
RU96109699/04A
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Russian (ru)
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RU2164913C2 (en
Inventor
Шварк Ян-Роберт
Ланг Ханс-Йохен
Клееманн Хайнц-Вернер
Вайхерт Андреас
Шольц Вольфганг
Альбус Удо
Original Assignee
Хехст АГ
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Publication date
Priority claimed from DE19518796A external-priority patent/DE19518796A1/en
Application filed by Хехст АГ filed Critical Хехст АГ
Publication of RU96109699A publication Critical patent/RU96109699A/en
Application granted granted Critical
Publication of RU2164913C2 publication Critical patent/RU2164913C2/en

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Claims (7)

1. Гуанидиды алкенилкарбоновых кислот, содержащие фторфенильные группы, формулы I
Figure 00000001

где R(6) - водород, (C1 - C8)-алкил, (C3 - C8)-циклоалкил или фенил, причем фенильная группа не замещена или замещена 1 - 3 заместителями, выбранными из группы, состоящей из F, Cl, CF3, метила, метокси и NR(9)R(10);
R(9) и R(10) - водород, (C1 - C4)-алкил или (C1 - C4)-перфторалкил;
R(7) независимо от R(6) имеет те же значения;
R(1), R(2), R(3), R(4) и R(5) означают независимо один от другого водород или F, причем по меньшей мере один из остатков R(1), R(2), R(3), R(4) и R(5) должен быть фтором;
а также их фармацевтически переносимые соли.1. Alkenylcarboxylic acid guanidides containing fluorophenyl groups of formula I
Figure 00000001

where R (6) is hydrogen, (C 1 - C 8 ) -alkyl, (C 3 - C 8 ) -cycloalkyl or phenyl, and the phenyl group is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, Cl, CF 3 , methyl, methoxy and NR (9) R (10);
R (9) and R (10) is hydrogen, (C 1 - C 4 ) -alkyl or (C 1 - C 4 ) -perfluoroalkyl;
R (7) regardless of R (6) has the same meaning;
R (1), R (2), R (3), R (4) and R (5) are independently hydrogen or F, and at least one of the residues R (1), R (2), R (3), R (4) and R (5) must be fluorine;
as well as their pharmaceutically tolerable salts. 2. Соединение формулы I по п.1, отличающееся тем, что в ней R(6) - водород, (C1 - C4)-алкил или (C3 - C6)-циклоалкил, R(7) от R(6) имеет те же значения, R(1), R(2), R(3), R(4) и R(5) означают независимо один от другого водород или F, причем по меньшей мере один из остатков R(1), R(2), R(3), R(4) и R(5) должен быть фтором.2. The compound of formula I according to claim 1, characterized in that R (6) is hydrogen, (C 1 - C 4 ) -alkyl or (C 3 - C 6 ) -cycloalkyl, R (7) from R ( 6) has the same meanings, R (1), R (2), R (3), R (4) and R (5) are independently hydrogen or F, and at least one of the residues R (1 ), R (2), R (3), R (4) and R (5) must be fluorine. 3. Соединение формулы I по п.1 или 2, в которой R(6) - водород или CH3, R(7) - водород, R(1), R(2), R(3), R(4) и R(5) - независимо один от другого водород или F, определен как R(1), причем по меньшей мере один из остатков R(1), R(2), R(3), R(4) и R(5) должен быть фтором.3. The compound of formula I according to claim 1 or 2, in which R (6) is hydrogen or CH 3 , R (7) is hydrogen, R (1), R (2), R (3), R (4) and R (5) is independently from each other hydrogen or F, is defined as R (1), at least one of the residues R (1), R (2), R (3), R (4) and R ( 5) must be fluoride. 4. Способ получения соединения I по п.1, отличающийся тем, что соединение формулы II
Figure 00000002

подвергают взаимодействию с гуанидином, причем R(1) - R(7) имеют указанные значения, L обозначает легко нуклеофильно замещаемую удаляемую группу.4. The method of obtaining compound I according to claim 1, characterized in that the compound of formula II
Figure 00000002

subjected to interaction with guanidine, and R (1) - R (7) have the indicated meanings, L stands for an easily nucleophilically replaceable leaving group. 5. Способ лечения и профилактики сердечных заболеваний, отличающийся тем, что применяют эффективное количество соединения I по п.1 в соответствующей лекарственной форме. 5. A method of treating and preventing heart disease, characterized in that an effective amount of the compound I according to claim 1 is applied in an appropriate dosage form. 6. Лекарственное или диагностическое средство, отличающееся тем, что оно содержит эффективное количество соединения формулы I по одному или нескольким пп. 1 - 3, при необходимости вместе с галеновыми вспомогательными веществами. 6. Drug or diagnostic agent, characterized in that it contains an effective amount of the compounds of formula I in one or more paragraphs. 1 - 3, if necessary, along with galenic excipients. 7. Способ получения лекарственного или диагностического средства, отличающийся тем, что эффективное количество активного вещества формулы I переводят в дозировочную форму. 7. A method of obtaining a medicinal or diagnostic agent, characterized in that an effective amount of the active substance of the formula I is transferred to the dosage form.
RU96109699/04A 1995-05-22 1996-05-17 ALKENYLCARBOXYLIC ACID GUANIDIDES, METHOD OF THEIR SYNTHESIS, METHOD OF INHIBITION OF CELLULAR Na+/H+-EXCHANGE AND PHARMACEUTICAL COMPOSITION RU2164913C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19518796A DE19518796A1 (en) 1995-05-22 1995-05-22 Fluorophenyl-substituted alkenylcarboxylic acid guanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
DE19518796.2 1995-05-22

Publications (2)

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RU96109699A true RU96109699A (en) 1998-08-20
RU2164913C2 RU2164913C2 (en) 2001-04-10

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US (2) US20010020042A1 (en)
EP (1) EP0744397B1 (en)
JP (1) JP3924018B2 (en)
KR (1) KR960041152A (en)
CN (1) CN1063437C (en)
AR (1) AR002744A1 (en)
AT (1) ATE192431T1 (en)
AU (1) AU701493B2 (en)
BR (1) BR9602394A (en)
CA (1) CA2177007C (en)
CZ (1) CZ291622B6 (en)
DE (2) DE19518796A1 (en)
DK (1) DK0744397T3 (en)
ES (1) ES2147629T3 (en)
GR (1) GR3033416T3 (en)
HR (1) HRP960230B1 (en)
HU (1) HUP9601358A3 (en)
IL (1) IL118327A (en)
MY (1) MY113803A (en)
NO (1) NO305552B1 (en)
NZ (1) NZ286622A (en)
PL (1) PL183431B1 (en)
PT (1) PT744397E (en)
RU (1) RU2164913C2 (en)
SI (1) SI0744397T1 (en)
SK (1) SK281527B6 (en)
TR (1) TR199600421A2 (en)
TW (1) TW415936B (en)
ZA (1) ZA964035B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160134A (en) * 1997-12-24 2000-12-12 Bristol-Myers Squibb Co. Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
US6011059A (en) * 1997-12-24 2000-01-04 Bristol-Myers Squibb Company Acyl guanidine sodium/proton exchange inhibitors and method
CA2370607A1 (en) 1999-04-23 2000-11-02 Bristol-Myers Squibb Company Bicyclic acyl guanidine sodium/proton exchange inhibitors and method
DE10046993A1 (en) 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituted cinnamic acid guanidides, process for their preparation, their use as a medicament and medicament containing them
EP2617709B8 (en) * 2003-06-26 2022-12-21 Biotron Limited Guanidine derivatives as antiviral agents
BRPI0612309B8 (en) 2005-06-24 2021-05-25 Biotron Ltd antiviral compounds and pharmaceutical compositions
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
MX345283B (en) 2008-12-31 2017-01-24 Ardelyx Inc Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders.
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
MX366293B (en) 2012-08-21 2019-07-04 Ardelyx Inc Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders.
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
JP6377132B2 (en) 2013-04-12 2018-08-22 アーデリクス，インコーポレーテッド NHE3-binding compounds and methods of inhibiting phosphate transport
EP3565808A1 (en) 2017-01-09 2019-11-13 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
EA201991676A1 (en) 2017-01-09 2020-01-30 Арделикс, Инк. NHE-MEDIATED ANTI-PORT INHIBITORS
AU2018335130B2 (en) 2017-08-04 2023-02-16 Ardelyx, Inc. Glycyrrhetinic acid derivatives for treating hyperkalemia
EP3921327B1 (en) 2019-02-07 2023-04-05 Ardelyx, Inc. Glycyrrhetinic acid derivatives for use in treating hyperkalemia
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2734904A (en) 1956-02-14 Xcxnhxc-nh
US564937A (en) * 1896-07-28 Culm-loader
US2743904A (en) 1950-11-07 1956-05-01 Loren F Scott Excavating apparatus
US3571861A (en) * 1968-11-26 1971-03-23 Famco Inc Bag closure means
US3612475A (en) * 1969-04-02 1971-10-12 Amp Inc Flexible tube closure
US3713622A (en) * 1971-02-26 1973-01-30 Amp Inc Closure device for flexible tubing
US3874042A (en) * 1973-01-22 1975-04-01 Biospectrum Inc Clamp for thin walled tubing
US3857396A (en) * 1973-08-22 1974-12-31 C Hardwick Suture clamp
US4547202A (en) * 1982-02-02 1985-10-15 Atlantic Richfield Company Hydrocarbon oils with improved pour points
US4454875A (en) * 1982-04-15 1984-06-19 Techmedica, Inc. Osteal medical staple
US4548201A (en) * 1982-04-20 1985-10-22 Inbae Yoon Elastic ligating ring clip
US4544670A (en) 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
US4534350A (en) * 1983-06-20 1985-08-13 Ethicon, Inc. Two-piece tissue fastener with compressible leg staple and retaining receiver
US4612923A (en) * 1983-12-01 1986-09-23 Ethicon, Inc. Glass-filled, absorbable surgical devices
US4646741A (en) * 1984-11-09 1987-03-03 Ethicon, Inc. Surgical fastener made from polymeric blends
US4955913A (en) * 1985-03-28 1990-09-11 Robinson Walter C Surgical tie
US4889119A (en) * 1985-07-17 1989-12-26 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
US5366459A (en) * 1987-05-14 1994-11-22 Inbae Yoon Surgical clip and clip application procedures
US4960420A (en) * 1988-08-23 1990-10-02 Marlowe Goble E Channel ligament clamp and system
US4932962A (en) * 1989-05-16 1990-06-12 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US4955959A (en) * 1989-05-26 1990-09-11 United States Surgical Corporation Locking mechanism for a surgical fastening apparatus
US4997433A (en) * 1990-01-16 1991-03-05 Marlowe Goble E Endosteal fixation stud and system
US5013316A (en) * 1990-03-26 1991-05-07 Marlowe Goble E Soft tissue anchor system
US5078731A (en) * 1990-06-05 1992-01-07 Hayhurst John O Suture clip
US5152034A (en) * 1990-10-19 1992-10-06 Konings Frederikus J J Click-clip
US5425489A (en) * 1990-12-20 1995-06-20 United States Surgical Corporation Fascia clip and instrument
US6102921A (en) * 1990-12-21 2000-08-15 University Of New Mexico Nerve anastomosis sling and method
US5203864A (en) * 1991-04-05 1993-04-20 Phillips Edward H Surgical fastener system
US5217472A (en) * 1991-05-07 1993-06-08 United States Surgical Corporation Surgical fastening device
US5257713A (en) * 1991-05-07 1993-11-02 United States Surgical Corporation Surgical fastening device
GB9111972D0 (en) * 1991-06-04 1991-07-24 Clinical Product Dev Ltd Medical/surgical devices
US5290217A (en) * 1991-10-10 1994-03-01 Earl K. Sipes Method and apparatus for hernia repair
US5289963A (en) * 1991-10-18 1994-03-01 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5497933A (en) * 1991-10-18 1996-03-12 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5356064A (en) * 1991-10-18 1994-10-18 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5333624A (en) * 1992-02-24 1994-08-02 United States Surgical Corporation Surgical attaching apparatus
US5171251A (en) * 1992-03-02 1992-12-15 Ethicon, Inc. Surgical clip having hole therein and method of anchoring suture
US5425737A (en) * 1992-04-08 1995-06-20 American Cyanamid Co. Surgical purse string suturing instrument and method
US6312442B1 (en) * 1992-06-02 2001-11-06 General Surgical Innovations, Inc. Method for developing an anatomic space for laparoscopic hernia repair
CA2104345A1 (en) * 1992-09-02 1994-03-03 David T. Green Surgical clamp apparatus
US5362294A (en) * 1992-09-25 1994-11-08 Seitzinger Michael R Sling for positioning internal organ during laparoscopic surgery and method of use
US5282832A (en) * 1992-10-09 1994-02-01 United States Surgical Corporation Suture clip
US5464416A (en) * 1992-11-10 1995-11-07 Ethicon, Inc. Ligating clip
US5328077A (en) * 1992-11-19 1994-07-12 Lou Ek Seng Method and apparatus for treating female urinary incontinence
US5649939A (en) * 1992-12-08 1997-07-22 Reddick; Eddie J. Laparoscopic suture introducer
DK0612723T3 (en) * 1993-02-20 1998-03-30 Hoechst Ag Substituted benzoylguanidines, method of preparation, their use as a drug, as an inhibitor of cellular Na + / H + exchange or as a diagnostic, and as a drug containing it
US5354292A (en) * 1993-03-02 1994-10-11 Braeuer Harry L Surgical mesh introduce with bone screw applicator for the repair of an inguinal hernia
US5474543A (en) * 1993-05-17 1995-12-12 Mckay; Hunter A. Single needle apparatus and method for performing retropublic urethropexy
US5507754A (en) * 1993-08-20 1996-04-16 United States Surgical Corporation Apparatus and method for applying and adjusting an anchoring device
CA2124651C (en) * 1993-08-20 2004-09-28 David T. Green Apparatus and method for applying and adjusting an anchoring device
DE4328869A1 (en) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
US5542594A (en) * 1993-10-06 1996-08-06 United States Surgical Corporation Surgical stapling apparatus with biocompatible surgical fabric
US5618290A (en) * 1993-10-19 1997-04-08 W.L. Gore & Associates, Inc. Endoscopic suture passer and method
US5776147A (en) * 1993-10-20 1998-07-07 Applied Medical Resources Corporation Laparoscopic surgical clamp
AU1011595A (en) * 1994-01-13 1995-07-20 Ethicon Inc. Spiral surgical tack
US5452836A (en) * 1994-02-07 1995-09-26 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with improved jaw closure and staple firing actuator mechanism
US5425740A (en) * 1994-05-17 1995-06-20 Hutchinson, Jr.; William B. Endoscopic hernia repair clip and method
DE4421536A1 (en) 1994-06-20 1995-12-21 Hoechst Ag Phenyl-substituted alkenylcarboxylic acid guanidines bearing perfluoroalkyl groups, processes for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
US5569306A (en) * 1995-06-06 1996-10-29 Thal; Raymond Knotless suture anchor assembly
DE69736174T2 (en) * 1996-04-19 2007-05-16 Applied Medical Resources Corp., Laguna Hills DEVICE FOR MOUNTING HOLDING CLIPS
US5816258A (en) * 1996-06-13 1998-10-06 General Surgical Innovations, Inc. Bladder neck suspension method
US6024748A (en) * 1996-07-23 2000-02-15 United States Surgical Corporation Singleshot anastomosis instrument with detachable loading unit and method
US6109500A (en) * 1996-10-04 2000-08-29 United States Surgical Corporation Lockout mechanism for a surgical stapler
CA2264672C (en) * 1996-10-24 2010-11-30 Spinal Concepts, Inc. Method and apparatus for spinal fixation
US5766250A (en) * 1996-10-28 1998-06-16 Medicinelodge, Inc. Ligament fixator for a ligament anchor system
US5954057A (en) * 1997-02-12 1999-09-21 Li Medical Technologies, Inc. Soft tissue suspension clip, clip assembly, emplacement tool and method
US5904692A (en) * 1997-04-14 1999-05-18 Mitek Surgical Products, Inc. Needle assembly and method for passing suture
US5960522A (en) * 1997-05-21 1999-10-05 Micron Electronics, Inc. Ribbon cable alligator clamp
US6099552A (en) * 1997-11-12 2000-08-08 Boston Scientific Corporation Gastrointestinal copression clips
WO1999058074A2 (en) * 1998-05-12 1999-11-18 Scimed Life Systems, Inc. Manual bone anchor placement devices

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