KR960041152A - Fluorophenyl-substituted alkenylcarboxylic acid guanidides, their preparation, their use as medicaments or diagnostic agents and medicaments containing them - Google Patents

Fluorophenyl-substituted alkenylcarboxylic acid guanidides, their preparation, their use as medicaments or diagnostic agents and medicaments containing them Download PDF

Info

Publication number
KR960041152A
KR960041152A KR1019960017109A KR19960017109A KR960041152A KR 960041152 A KR960041152 A KR 960041152A KR 1019960017109 A KR1019960017109 A KR 1019960017109A KR 19960017109 A KR19960017109 A KR 19960017109A KR 960041152 A KR960041152 A KR 960041152A
Authority
KR
South Korea
Prior art keywords
compound
medicament
preparation
hydrogen
treatment
Prior art date
Application number
KR1019960017109A
Other languages
Korean (ko)
Inventor
슈바르크 안-로베르트
요헨 랑 한스
클레만 하인츠-베르너
바이헤르트 안드레아스
숄츠 볼프강
알부스 우도
Original Assignee
로제르트, 루스
훽스트 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 로제르트, 루스, 훽스트 아크티엔게젤샤프트 filed Critical 로제르트, 루스
Publication of KR960041152A publication Critical patent/KR960041152A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/10—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by doubly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

본 발명은 하기 일반식(Ⅰ)의 플루오로페닐－치환된 알케닐카복실산 구아니디드, 이의 제조방법, 약제 또는 진단제로서의 이의 용도 및 이를 함유하는 약재에 관한 것이다:The present invention relates to fluorophenyl-substituted alkenylcarboxylic acid guanidides of the general formula (I), their use as medicaments or diagnostic agents, and medicaments containing them.

상기 식에서, 치환제 R(1) 내지 R(7)은 특허청구의 범위 정의된 바와 같고, 이의 약제학적으로 허용되는 염은 세포의 나트륨/양성자 교환기(Na+/H+교환기)의 유용한 억제제이다. 따라서, 본 발명의 화합물은 Na+/H+교환의 증가에 기인하는 모든 질환의 치료에 현저하게 적합하다.Wherein the substituents R (1) to R (7) are as defined in the claims and the pharmaceutically acceptable salts thereof are useful inhibitors of the sodium / proton exchanger (Na + / H + exchanger) of the cell . Therefore, the compounds of the present invention are remarkably suitable for the treatment of all diseases caused by an increase in Na + / H + exchange.

Description

플루오로페닐－치환된 알케닐카복실산 구아니디드, 이의 제조 방법, 약제 또는 진단제로서의 이의 용도 및 이를 함유하는 약제Fluorophenyl-substituted alkenylcarboxylic acid guanidides, their preparation, their use as medicaments or diagnostic agents and medicaments containing them

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (17)

플루오로페닐 그룹을 포함하는 일반식(Ⅰ)의 알케닐카복실산 구아니디드 및 이의 약제학적으로 허용되는 염.An alkenylcarboxylic acid guanidide of the general formula (I) containing a fluorophenyl group, and pharmaceutically acceptable salts thereof. 상기 식에서, R(6)은 수소, (C1－C8)－알킬, (C3－C8)－사이클로알킬 또는 페닐(여기서, 페닐 그룹은 F, Cl, CF3, 메틸, 메톡시 및 NR(9)－R(10)으로 이루어진 그룹 중에서 선택된 1 내지 3개의 치환체에 의해 치환되거나 비치환된다)이고; R(9) 및 R(10)은 수소, (C1－C4)－알킬 또는 (C1－C4)－퍼플루오로알킬이며; R(7)은 독립적으로 R(6)에서와 동일한 방법으로 정의되고; R(1), R(2), R(3), R(4) 및 R(5)는 서로 독립적으로 수소 또는 F이고, 단 라디칼(R(1), R(2), R(3), R(4) 및 R(5)중 하나 이상은 불소이다.Wherein R 6 is hydrogen, (C 1 -C 8 ) -alkyl, (C 3 -C 8 ) -cycloalkyl or phenyl, wherein the phenyl group is F, Cl, CF 3 , methyl, methoxy and NR (9) -R (10); < / RTI > R (9) and R (10) is hydrogen, (C 1 -C 4) - alkyl or (C 1 -C 4) - perfluoroalkyl, and; R (7) is independently defined in the same manner as in R (6); R (1), R (2), R (3), R (4) and R (5) independently of one another are hydrogen or F, , R (4) and R (5) is fluorine. 제1항에 있어서, R(6)이 수소, (C1－C4)－알킬 또는 (C3－C6)－사이클로알킬이고, R(7)이 독립적으로 R(6)에서와 동일한 방법으로 정의되며, R(1), R(2), R(3), R(4) 및 R(5)가 서로 독립적으로 수소 또는 F이고, 단 라디칼 R(1), R(2), R(3), R(4) 및 R(5)중 하나 이상이 불소인 일반식(Ⅰ)의 화합물.The method of claim 1, wherein R (6) is hydrogen, (C 1 -C 4 ) -alkyl or (C 3 -C 6 ) -cycloalkyl and R (7) R (1), R (2), R (3), R (4) and R (5) independently of one another are hydrogen or F, (I) wherein at least one of R (3), R (4) and R (5) is fluorine. 제1항 또는 제2항에 있어서, R(6)이 수소 또는 CF3이고, R(7)이 수소이며, R(1), R(2), R(3), R(4) 및 R(5)가 서로 독립적으로 수소 또는 F이고, 단 라디칼 R(1), R(2), R(3), R(4) 및 R(5)중 하나 이상이 불소인 일반식(Ⅰ)의 화합물.According to claim 1 or 2, R (6) is hydrogen or CF 3, and R (7) is hydrogen, R (1), R ( 2), R (3), R (4) and R (I) wherein at least one of the radicals R (1), R (2), R (3), R (4) and R (5) is independently hydrogen or F, compound. 일반식(Ⅱ)의 화합물을 구아니딘과 반응시킴을 포함하여 제1항에 정의된 바와 같은 화합물(Ⅰ)을 제조하는 방법:Process for preparing compound (I) as defined in claim 1, comprising reacting a compound of formula (II) with guanidine: 상기 식에서, R(1) 내지 R(7), R(9) 및 R(10)은 제1항에서 정의된 바와 같고, L은 친핵성 치환에 민감한 이탈 그룹이다.Wherein R (1) to R (7), R (9) and R (10) are as defined in claim 1 and L is a leaving group sensitive to nucleophilic substitution. 부정맥 치료용 약제의 제조를 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the manufacture of a medicament for the treatment of arrhythmia. 제1항에 정의된 바와 같은 화합물(Ⅰ)의 유효량을 통상의 첨가제와 배합하고 적합한 투여 형태로 상기 화합물을 투여함을 포함하여 부정맥을 치료하는 방법.A method of treating arrhythmias, comprising combining an effective amount of compound (I) as defined in claim 1 with conventional additives and administering the compound in a suitable dosage form. 심장경색의 치료 또는 예방용 약제를 제조하기 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the preparation of a medicament for the treatment or prevention of cardiac infarction. 협심증의 치료 또는 예방용 약제를 제조하기 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the preparation of a medicament for the treatment or prevention of angina. 허혈성 심장질환의 치료 또는 예방용 약제를 제조하기 위한 제1항에 정의된 방과 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the preparation of a medicament for the treatment or prevention of ischemic heart disease. 말초신경계 및 중추신경계의 허혈성 질환 및 발작의 치료 또는 예방용 약제를 제조하기 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.The use of compound (I) as defined in claim 1 for the preparation of a medicament for the treatment or prevention of ischemic diseases and seizures of the peripheral nervous system and central nervous system. 말초기관 및 손발의 허혈성 질환의 치료 또는 예방용 약제를 제조하기 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the preparation of a medicament for the treatment or prevention of ischemic diseases of peripheral organs and limbs. 쇼크 질환의 치료용 약제를 제조하기 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the manufacture of a medicament for the treatment of shock disorders. 외과 수술 및 조직 이식에 사용하는 약제를 제조하기 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the preparation of a medicament for use in surgery and tissue transplantation. 외과 수술을 위한 조직 이식편의 보존 및 저장용 약제를 제조하기 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the preparation of a medicament for the preservation and storage of tissue grafts for surgical operations. 세포 증식이 1차 또는 2차 원인인 질환을 치료하여 항아테롬성 동맥경화제 또는 후기 당료병 합병증, 암종증, 폐 섬유증, 간장 섬유증 또는 신장 섬유증과 같은 섬유성 질환 및 전립선 과형성을 퇴치하는 제제로서 유용한 약제를 제조하기 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.A medicament useful as an agent for combating hyperplastic atherosclerosis or late metaplasia complications, fibrosing diseases such as carcinomatosis, pulmonary fibrosis, hepatic fibrosis or renal fibrosis, and prostate hyperplasia by treating a disease in which cell proliferation is the primary or secondary cause Lt; RTI ID = 0.0 > (I) < / RTI > 긴장항진 및 증식성 질환의 진단을 위해 Na+/H+교환기를 억제시키는 과학적 기구의 제조를 위한 제1항에 정의된 바와 같은 화합물(Ⅰ)의 용도.Use of compound (I) as defined in claim 1 for the manufacture of a scientific instrument for inhibiting Na + / H + exchange for the diagnosis of hypertension and proliferative diseases. 제1항 내지 제3항 중의 어느 한 항에 정의된 바와 같은 유효량의 화합물을 포함하는 약물.A medicament comprising an effective amount of a compound as defined in any one of claims 1 to 3. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019960017109A 1995-05-22 1996-05-21 Fluorophenyl-substituted alkenylcarboxylic acid guanidides, their preparation, their use as medicaments or diagnostic agents and medicaments containing them KR960041152A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19518796.2 1995-05-22
DE19518796A DE19518796A1 (en) 1995-05-22 1995-05-22 Fluorophenyl-substituted alkenylcarboxylic acid guanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Publications (1)

Publication Number Publication Date
KR960041152A true KR960041152A (en) 1996-12-19

Family

ID=7762597

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960017109A KR960041152A (en) 1995-05-22 1996-05-21 Fluorophenyl-substituted alkenylcarboxylic acid guanidides, their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Country Status (29)

Country Link
US (2) US20010020042A1 (en)
EP (1) EP0744397B1 (en)
JP (1) JP3924018B2 (en)
KR (1) KR960041152A (en)
CN (1) CN1063437C (en)
AR (1) AR002744A1 (en)
AT (1) ATE192431T1 (en)
AU (1) AU701493B2 (en)
BR (1) BR9602394A (en)
CA (1) CA2177007C (en)
CZ (1) CZ291622B6 (en)
DE (2) DE19518796A1 (en)
DK (1) DK0744397T3 (en)
ES (1) ES2147629T3 (en)
GR (1) GR3033416T3 (en)
HR (1) HRP960230B1 (en)
HU (1) HUP9601358A3 (en)
IL (1) IL118327A (en)
MY (1) MY113803A (en)
NO (1) NO305552B1 (en)
NZ (1) NZ286622A (en)
PL (1) PL183431B1 (en)
PT (1) PT744397E (en)
RU (1) RU2164913C2 (en)
SI (1) SI0744397T1 (en)
SK (1) SK281527B6 (en)
TR (1) TR199600421A2 (en)
TW (1) TW415936B (en)
ZA (1) ZA964035B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011059A (en) * 1997-12-24 2000-01-04 Bristol-Myers Squibb Company Acyl guanidine sodium/proton exchange inhibitors and method
US6160134A (en) * 1997-12-24 2000-12-12 Bristol-Myers Squibb Co. Process for preparing chiral cyclopropane carboxylic acids and acyl guanidines
AU4360200A (en) 1999-04-23 2000-11-10 Bristol-Myers Squibb Company Bicyclic acyl guanidine sodium/proton exchange inhibitors and method
DE10046993A1 (en) * 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituted cinnamic acid guanidides, process for their preparation, their use as a medicament and medicament containing them
EP2617709B8 (en) * 2003-06-26 2022-12-21 Biotron Limited Guanidine derivatives as antiviral agents
AU2013205388B2 (en) * 2005-06-24 2016-05-05 Biotron Limited Antiviral compounds and methods
PT2826770T (en) * 2005-06-24 2018-12-18 Biotron Ltd Acylguanidine compounds with antiviral activity
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
KR20200111230A (en) 2008-12-31 2020-09-28 알데릭스, 인코포레이티드 Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2014029983A1 (en) 2012-08-21 2014-02-27 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
MX2015014351A (en) 2013-04-12 2016-04-20 Ardelyx Inc Nhe3-binding compounds and methods for inhibiting phosphate transport.
CN110291082A (en) 2017-01-09 2019-09-27 阿德利克斯股份有限公司 The inhibitor for the antiport that NHE is mediated
AU2018205400B2 (en) 2017-01-09 2022-07-14 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
MA49761A (en) 2017-08-04 2020-06-10 Ardelyx Inc GLYCYRRHETINIC ACID DERIVATIVES FOR HYPERKALIEMIA TREATMENT
SG11202108541RA (en) 2019-02-07 2021-09-29 Ardelyx Inc Glycyrrhetinic acid derivatives for use in treating hyperkalemia
EP3972599A1 (en) 2019-05-21 2022-03-30 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US564937A (en) * 1896-07-28 Culm-loader
US2734904A (en) 1956-02-14 Xcxnhxc-nh
US2743904A (en) 1950-11-07 1956-05-01 Loren F Scott Excavating apparatus
US3571861A (en) * 1968-11-26 1971-03-23 Famco Inc Bag closure means
US3612475A (en) * 1969-04-02 1971-10-12 Amp Inc Flexible tube closure
US3713622A (en) * 1971-02-26 1973-01-30 Amp Inc Closure device for flexible tubing
US3874042A (en) * 1973-01-22 1975-04-01 Biospectrum Inc Clamp for thin walled tubing
US3857396A (en) * 1973-08-22 1974-12-31 C Hardwick Suture clamp
US4547202A (en) * 1982-02-02 1985-10-15 Atlantic Richfield Company Hydrocarbon oils with improved pour points
US4454875A (en) * 1982-04-15 1984-06-19 Techmedica, Inc. Osteal medical staple
US4548201A (en) * 1982-04-20 1985-10-22 Inbae Yoon Elastic ligating ring clip
US4544670A (en) 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
US4534350A (en) * 1983-06-20 1985-08-13 Ethicon, Inc. Two-piece tissue fastener with compressible leg staple and retaining receiver
US4612923A (en) * 1983-12-01 1986-09-23 Ethicon, Inc. Glass-filled, absorbable surgical devices
US4646741A (en) * 1984-11-09 1987-03-03 Ethicon, Inc. Surgical fastener made from polymeric blends
US4955913A (en) * 1985-03-28 1990-09-11 Robinson Walter C Surgical tie
US4889119A (en) * 1985-07-17 1989-12-26 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
US5366459A (en) * 1987-05-14 1994-11-22 Inbae Yoon Surgical clip and clip application procedures
US4960420A (en) * 1988-08-23 1990-10-02 Marlowe Goble E Channel ligament clamp and system
US4932962A (en) * 1989-05-16 1990-06-12 Inbae Yoon Suture devices particularly useful in endoscopic surgery and methods of suturing
US4955959A (en) * 1989-05-26 1990-09-11 United States Surgical Corporation Locking mechanism for a surgical fastening apparatus
US4997433A (en) * 1990-01-16 1991-03-05 Marlowe Goble E Endosteal fixation stud and system
US5013316A (en) * 1990-03-26 1991-05-07 Marlowe Goble E Soft tissue anchor system
US5078731A (en) * 1990-06-05 1992-01-07 Hayhurst John O Suture clip
US5152034A (en) * 1990-10-19 1992-10-06 Konings Frederikus J J Click-clip
US5425489A (en) * 1990-12-20 1995-06-20 United States Surgical Corporation Fascia clip and instrument
US6102921A (en) * 1990-12-21 2000-08-15 University Of New Mexico Nerve anastomosis sling and method
US5203864A (en) * 1991-04-05 1993-04-20 Phillips Edward H Surgical fastener system
US5217472A (en) * 1991-05-07 1993-06-08 United States Surgical Corporation Surgical fastening device
US5257713A (en) * 1991-05-07 1993-11-02 United States Surgical Corporation Surgical fastening device
GB9111972D0 (en) * 1991-06-04 1991-07-24 Clinical Product Dev Ltd Medical/surgical devices
US5290217A (en) * 1991-10-10 1994-03-01 Earl K. Sipes Method and apparatus for hernia repair
US5289963A (en) * 1991-10-18 1994-03-01 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5356064A (en) * 1991-10-18 1994-10-18 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5497933A (en) * 1991-10-18 1996-03-12 United States Surgical Corporation Apparatus and method for applying surgical staples to attach an object to body tissue
US5333624A (en) * 1992-02-24 1994-08-02 United States Surgical Corporation Surgical attaching apparatus
US5171251A (en) * 1992-03-02 1992-12-15 Ethicon, Inc. Surgical clip having hole therein and method of anchoring suture
US5425737A (en) * 1992-04-08 1995-06-20 American Cyanamid Co. Surgical purse string suturing instrument and method
US6312442B1 (en) * 1992-06-02 2001-11-06 General Surgical Innovations, Inc. Method for developing an anatomic space for laparoscopic hernia repair
CA2104345A1 (en) * 1992-09-02 1994-03-03 David T. Green Surgical clamp apparatus
US5362294A (en) * 1992-09-25 1994-11-08 Seitzinger Michael R Sling for positioning internal organ during laparoscopic surgery and method of use
US5282832A (en) * 1992-10-09 1994-02-01 United States Surgical Corporation Suture clip
US5464416A (en) * 1992-11-10 1995-11-07 Ethicon, Inc. Ligating clip
US5328077A (en) * 1992-11-19 1994-07-12 Lou Ek Seng Method and apparatus for treating female urinary incontinence
US5649939A (en) * 1992-12-08 1997-07-22 Reddick; Eddie J. Laparoscopic suture introducer
DE59403818D1 (en) * 1993-02-20 1997-10-02 Hoechst Ag Substituted benzoylguanidines, processes for their preparation, their use as medicaments, as inhibitors of cellular Na + / H + exchange or as diagnostic agents and medicaments containing them
US5354292A (en) * 1993-03-02 1994-10-11 Braeuer Harry L Surgical mesh introduce with bone screw applicator for the repair of an inguinal hernia
US5474543A (en) * 1993-05-17 1995-12-12 Mckay; Hunter A. Single needle apparatus and method for performing retropublic urethropexy
CA2124651C (en) * 1993-08-20 2004-09-28 David T. Green Apparatus and method for applying and adjusting an anchoring device
US5507754A (en) * 1993-08-20 1996-04-16 United States Surgical Corporation Apparatus and method for applying and adjusting an anchoring device
DE4328869A1 (en) * 1993-08-27 1995-03-02 Hoechst Ag Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
US5542594A (en) * 1993-10-06 1996-08-06 United States Surgical Corporation Surgical stapling apparatus with biocompatible surgical fabric
US5618290A (en) * 1993-10-19 1997-04-08 W.L. Gore & Associates, Inc. Endoscopic suture passer and method
US5776147A (en) * 1993-10-20 1998-07-07 Applied Medical Resources Corporation Laparoscopic surgical clamp
AU1011595A (en) * 1994-01-13 1995-07-20 Ethicon Inc. Spiral surgical tack
US5452836A (en) * 1994-02-07 1995-09-26 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with improved jaw closure and staple firing actuator mechanism
US5425740A (en) * 1994-05-17 1995-06-20 Hutchinson, Jr.; William B. Endoscopic hernia repair clip and method
DE4421536A1 (en) 1994-06-20 1995-12-21 Hoechst Ag Phenyl-substituted alkenylcarboxylic acid guanidines bearing perfluoroalkyl groups, processes for their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
US5569306A (en) * 1995-06-06 1996-10-29 Thal; Raymond Knotless suture anchor assembly
WO1997039689A1 (en) * 1996-04-19 1997-10-30 Applied Medical Resources Corporation Grasping clip applier
US5816258A (en) * 1996-06-13 1998-10-06 General Surgical Innovations, Inc. Bladder neck suspension method
US6024748A (en) * 1996-07-23 2000-02-15 United States Surgical Corporation Singleshot anastomosis instrument with detachable loading unit and method
US6109500A (en) * 1996-10-04 2000-08-29 United States Surgical Corporation Lockout mechanism for a surgical stapler
EP0934026B1 (en) * 1996-10-24 2009-07-15 Zimmer Spine Austin, Inc Apparatus for spinal fixation
US5766250A (en) * 1996-10-28 1998-06-16 Medicinelodge, Inc. Ligament fixator for a ligament anchor system
US5954057A (en) * 1997-02-12 1999-09-21 Li Medical Technologies, Inc. Soft tissue suspension clip, clip assembly, emplacement tool and method
US5904692A (en) * 1997-04-14 1999-05-18 Mitek Surgical Products, Inc. Needle assembly and method for passing suture
US5960522A (en) * 1997-05-21 1999-10-05 Micron Electronics, Inc. Ribbon cable alligator clamp
US6099552A (en) * 1997-11-12 2000-08-08 Boston Scientific Corporation Gastrointestinal copression clips
WO1999058074A2 (en) * 1998-05-12 1999-11-18 Scimed Life Systems, Inc. Manual bone anchor placement devices

Also Published As

Publication number Publication date
NZ286622A (en) 1997-08-22
PL183431B1 (en) 2002-06-28
ZA964035B (en) 1997-11-21
SK281527B6 (en) 2001-04-09
NO305552B1 (en) 1999-06-21
ES2147629T3 (en) 2000-09-16
CA2177007A1 (en) 1996-11-23
HUP9601358A3 (en) 1997-10-28
CN1063437C (en) 2001-03-21
CZ145096A3 (en) 1996-12-11
BR9602394A (en) 1998-10-06
EP0744397B1 (en) 2000-05-03
SI0744397T1 (en) 2000-08-31
TW415936B (en) 2000-12-21
RU2164913C2 (en) 2001-04-10
AU701493B2 (en) 1999-01-28
AR002744A1 (en) 1998-04-29
SK65196A3 (en) 1996-12-04
US20020123529A1 (en) 2002-09-05
CZ291622B6 (en) 2003-04-16
HUP9601358A2 (en) 1997-05-28
DE59605101D1 (en) 2000-06-08
TR199600421A2 (en) 1997-03-21
CN1138029A (en) 1996-12-18
JPH08319266A (en) 1996-12-03
GR3033416T3 (en) 2000-09-29
DE19518796A1 (en) 1996-11-28
EP0744397A3 (en) 1997-03-26
IL118327A (en) 2002-12-01
NO962063D0 (en) 1996-05-21
IL118327A0 (en) 1996-09-12
US6504057B2 (en) 2003-01-07
MY113803A (en) 2002-05-31
HRP960230B1 (en) 2000-12-31
DK0744397T3 (en) 2000-08-28
PT744397E (en) 2000-09-29
AU5237396A (en) 1996-12-05
HRP960230A2 (en) 1997-12-31
JP3924018B2 (en) 2007-06-06
CA2177007C (en) 2009-01-06
US20010020042A1 (en) 2001-09-06
ATE192431T1 (en) 2000-05-15
NO962063L (en) 1996-11-25
EP0744397A2 (en) 1996-11-27
PL314252A1 (en) 1996-11-25
HU9601358D0 (en) 1996-07-29

Similar Documents

Publication Publication Date Title
KR960041152A (en) Fluorophenyl-substituted alkenylcarboxylic acid guanidides, their preparation, their use as medicaments or diagnostic agents and medicaments containing them
KR950005817A (en) A benzo-fused heterocyclic compound having a 5-membered ring, its preparation method, its use as a medicine, its use as a diagnostic agent and medicaments containing it
KR950022159A (en) Substituted 1-oxo-1,2-dihydroisoquinolinoylguanidine and 1,1-dioxo-2H-1,2-benzothiazinoylguanidine, their preparation, use as a medicament or diagnostic agent And medicaments comprising them
NO160439C (en) ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE SUBSTITUTED IMIDAZOLE DERIVATIVES.
JPH069545A (en) O-substituted benzoylguanidine, its production, its use as medicine or diagnostic agent, and medicine containing it
HU223537B1 (en) Perfluoroalkyl-substituted benzoyl-guanidine, process for producing them, use of them as medicament or diagnosticum, and pharmaceutical composition containing them
SK281766B6 (en) Substituted sulphonimidamides, method for their preparation, their use as medicament or diagnostic and medicament containing them
CZ403392A3 (en) Amino-substituted benzylguanidines, process of their preparation, their use as medicaments and a medicament containing thereof
RU2270679C2 (en) Medicinal agent for hypertension treatment
US3769427A (en) Pharmaceutical compositions and methods of using same
KR960029320A (en) Basic substituted benzoylguanidines, their preparation, their use as medicaments or diagnostic agents and medicaments containing them
KR970015568A (en) Substituted Benzoylguanidine, Method of Making the Same, Use thereof as a medicament or a diagnostic agent, and a pharmaceutical comprising the same
KR970006281A (en) Substituted cinnamic acid guanidide, a process for its preparation, its use as a drug or diagnostic agent and medicaments containing it
KR950032129A (en) Substituted bicyclic heteroaroylguanidines, methods for their preparation, their use as medicaments or diagnostic agents and medicaments containing the same
JPH02270855A (en) Anti-inflammatory aryl compound
US4505921A (en) Sulfonylurea compounds and their use in treating diabetes
KR960010619A (en) Benzoylguanidines substituted by heterocyclic N-oxides, methods for their preparation, their use as medicaments or diagnostic agents, medicaments containing them and intermediate products for their preparation
RU95115511A (en) BENZOILGUANIDINES, METHOD FOR THEIR PRODUCTION, THEIR USE AS A MEDICAL OR DIAGNOSTIC MEDICINE CONTAINING THEIR MEDICINAL AND INTERMEDIATE CONNECTIONS FOR THEIR RECEIVING
DE60117131T2 (en) PYRIDAZINYL PHENYL HYDRAZONE USEFUL AGAINST CONGESTIVE HEART FAILURE
KR970006282A (en) 4-Fluoroalkyl-substituted benzoylguanidines, their preparation, their use as medicaments or diagnostic agents, and medicaments containing them
FI834800A (en) FOERFARANDE FOER FRAMSTAELLNING AV DIALKYLAMINOALKOXIBENSYLALKOHOL-DERIVAT.
AU2922389A (en) Improving toxicity profiles in chemotherapy
RU97113146A (en) SUBSTITUTED INDANYLIDINACETHYLGUANIDINES, METHOD FOR PRODUCING THEM, USE AS MEDICINES OR DIAGNOSTIC MEDICINES AND MEDICINES CONTAINING THESE COMPOUNDS
US4468520A (en) 3-Cyano-indoles as cardioselective agents
RU97109528A (en) ORTO-SUBSTITUTED BENZOILGUANIDINES, THE WAY OF THEIR RECEPTION, THEIR USE AS A MEDICINE OR DIAGNOSTIC MEANS AND CONTAINING THEIR MEDICINE

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application