RU98106625A - Derivatives of colchicine and thiocolchicine, possessing anti-inflammatory and myorelaxing activities - Google Patents

Derivatives of colchicine and thiocolchicine, possessing anti-inflammatory and myorelaxing activities

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Publication number
RU98106625A
RU98106625A RU98106625/04A RU98106625A RU98106625A RU 98106625 A RU98106625 A RU 98106625A RU 98106625/04 A RU98106625/04 A RU 98106625/04A RU 98106625 A RU98106625 A RU 98106625A RU 98106625 A RU98106625 A RU 98106625A
Authority
RU
Russia
Prior art keywords
inflammatory
myorelaxing
thiocolchicine
colchicine
activities
Prior art date
Application number
RU98106625/04A
Other languages
Russian (ru)
Other versions
RU2190598C2 (en
Inventor
Бомбарделли Эцио
Original Assignee
Индена С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT97MI000845A external-priority patent/IT1291550B1/en
Application filed by Индена С.П.А. filed Critical Индена С.П.А.
Publication of RU98106625A publication Critical patent/RU98106625A/en
Application granted granted Critical
Publication of RU2190598C2 publication Critical patent/RU2190598C2/en

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Claims (1)

1. Соединения общей формулы I:
Figure 00000001

в которой R может представлять собой
Figure 00000002
НОСН2-СНОН-СН2-, H2NCH2CHOHCH2-, HOOCCH2-, OH-CH2-CHC1-CH2-.1. The compounds of General formula I:
Figure 00000001

in which R may be
Figure 00000002
HOSN 2 -CHOH-CH 2 -, H2NCH 2 CHOHCH 2 -, HOOCCH 2 -, OH-CH 2 -CHC1-CH 2 -. 2. Способ получения соединений по п. 1 в соответствии со следующей схемой 1:
3. Применение соединений по п. 1 для получения лекарственных препаратов, применимых в качестве миорелаксантов, противовоспалительных средств, спазмолитиков, противоподагрических средств.2. A method of producing compounds according to claim 1 in accordance with the following scheme 1:
3. The use of compounds according to claim 1 for the manufacture of medications useful as muscle relaxants, anti-inflammatory drugs, antispasmodics, anti-gout agents. 4. Фармацевтические композиции, содержащие соединение по п. 1 в качестве активного ингредиента в смеси с фармацевтически приемлемыми носителями и наполнителями. 4. Pharmaceutical compositions containing the compound of claim 1 as an active ingredient in admixture with pharmaceutically acceptable carriers and excipients. 5. Фармацевтические композиции по п. 4 в форме капсул, таблеток, гранул, суппозиториев, кремов, растворов для инъекций, мазей и гелей. 5. The pharmaceutical compositions of claim 4 in the form of capsules, tablets, granules, suppositories, creams, injectable solutions, ointments and gels.
RU98106625/04A 1997-04-11 1998-04-08 Derivatives of thiocolchicine, methods of their synthesis, compound, pharmaceutical composition RU2190598C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI97A000845 1997-04-11
IT97MI000845A IT1291550B1 (en) 1997-04-11 1997-04-11 DERIVATIVES OF COLCHICINE AND THIOCOLCHICINE WITH ANTI-INFLAMMATORY AND MYORELAXING ACTIVITIES

Publications (2)

Publication Number Publication Date
RU98106625A true RU98106625A (en) 2000-01-27
RU2190598C2 RU2190598C2 (en) 2002-10-10

Family

ID=11376857

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98106625/04A RU2190598C2 (en) 1997-04-11 1998-04-08 Derivatives of thiocolchicine, methods of their synthesis, compound, pharmaceutical composition

Country Status (16)

Country Link
US (1) US5973204A (en)
EP (1) EP0870761B1 (en)
JP (1) JP2916470B2 (en)
KR (1) KR100559526B1 (en)
CN (1) CN1089336C (en)
AT (1) ATE260252T1 (en)
AU (1) AU738857B2 (en)
CA (1) CA2234480C (en)
DE (1) DE69821815T2 (en)
DK (1) DK0870761T3 (en)
ES (1) ES2216197T3 (en)
HK (1) HK1017880A1 (en)
IT (1) IT1291550B1 (en)
PT (1) PT870761E (en)
RU (1) RU2190598C2 (en)
SI (1) SI0870761T1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) * 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6720323B2 (en) * 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6825236B2 (en) * 2003-04-14 2004-11-30 California Pacific Medical Center Colchicine derivatives
WO2004113281A1 (en) 2003-06-25 2004-12-29 Je Il Pharmaceutical Co., Ltd. Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them
ITMI20051418A1 (en) * 2005-07-22 2007-01-23 Indena Spa ANALOGUES OF THIOILCYCOSIDE WITH HYDRO-LASER ACTIVITY AND ANTI-INFLAMMATORY
JP5435995B2 (en) * 2009-01-30 2014-03-05 出光興産株式会社 Method for producing cyclic compound
US8497290B2 (en) * 2009-05-27 2013-07-30 Takeda Pharmaceuticals U.S.A., Inc. Thiocolchicine derivatives, method of making and methods of use thereof
WO2011091114A2 (en) * 2010-01-22 2011-07-28 Mutual Pharmaceutical Company, Inc. Thiocolchicine and colchicine analogs, methods of making and methods of use thereof
EP2924022A1 (en) * 2014-03-27 2015-09-30 INDENA S.p.A. Amorphous form of a thiocolchicine derivative
EP3813821A4 (en) * 2018-06-29 2022-05-04 Alberta Health Services Methods and uses of colchicine derivatives
RU2740530C1 (en) * 2020-06-11 2021-01-15 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Method for prevention of postpericardiotomy syndrome and atrial fibrillation paroxysms in cardiosurgical patients

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2820029A (en) * 1954-02-10 1958-01-14 U C L A F New thio-derivatives of colchiceine compounds and a process of making same
FR1344474A (en) * 1962-10-18 1963-11-29 Roussel Uclaf Colchicine and thiocolchicine derivatives and method of preparation
EP0356137B1 (en) * 1988-08-24 1994-10-26 Advance Biofactures Corporation Carbonates of 3-demethylthiocolchicine and N-acyl analogs
IT1276996B1 (en) * 1995-06-27 1997-11-04 Indena Spa COLCHICINE DERIVATIVES, THEIR USE AND FORMULATIONS CONTAINING THEM

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