RU97112145A - GETTING CEFOTAXIM - Google Patents

GETTING CEFOTAXIM

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Publication number
RU97112145A
RU97112145A RU97112145/04A RU97112145A RU97112145A RU 97112145 A RU97112145 A RU 97112145A RU 97112145/04 A RU97112145/04 A RU 97112145/04A RU 97112145 A RU97112145 A RU 97112145A RU 97112145 A RU97112145 A RU 97112145A
Authority
RU
Russia
Prior art keywords
formula
compound
acetone
sodium salt
water
Prior art date
Application number
RU97112145/04A
Other languages
Russian (ru)
Other versions
RU2169150C2 (en
Inventor
Махер Ингольф
Видшвентер Герхард
Original Assignee
Биокеми Гезелльшафт мбХ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT0239794A external-priority patent/AT402928B/en
Application filed by Биокеми Гезелльшафт мбХ filed Critical Биокеми Гезелльшафт мбХ
Publication of RU97112145A publication Critical patent/RU97112145A/en
Application granted granted Critical
Publication of RU2169150C2 publication Critical patent/RU2169150C2/en

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Claims (11)

1. Способ получения соединения формулы I
Figure 00000001

при котором соединение формулы II
Figure 00000002

подвергают взаимодействию с соединением формулы III
Figure 00000003

в ацетоне.1. The method of obtaining the compounds of formula I
Figure 00000001

wherein the compound of formula II
Figure 00000002

react with a compound of formula III
Figure 00000003

in acetone. 2. Способ по п.1, отличающийся тем, что присутствует вода. 2. The method according to claim 1, characterized in that water is present. 3. Способ по п.1 или 2, отличающийся тем, что присутствует основание. 3. The method according to claim 1 or 2, characterized in that there is a base. 4. Способ получения натриевой соли соединения формулы 1, определенной в п.1, при котором используют способ по п.1. 4. A method of producing a sodium salt of a compound of formula 1 as defined in claim 1, wherein the method of claim 1 is used. 5. Способ получения натриевой соли соединения формулы 1, определенной в п. 1, при котором соединение формулы II подвергают взаимодействию с соединением формулы III в ацетоне; соединение 1, полученное на стадии 1), подвергают превращению в присутствии источника ионов натрия в ацетоне. 5. A method for producing the sodium salt of a compound of formula 1, as defined in claim 1, wherein the compound of formula II is reacted with a compound of formula III in acetone; compound 1 obtained in stage 1) is subjected to conversion in the presence of a source of sodium ions in acetone. 6. Способ по п.5, отличающийся тем, что присутствует вода. 6. The method according to claim 5, characterized in that water is present. 7. Способ получения цефотаксима натрия формулы Ia
Figure 00000004

при котором 7-АСА указанной формулы II в п.1 подвергают взаимодействию с соединением указанной формулы III в п. 1 в растворителе, представляющем собой смесь ацетона и воды, в присутствии основания и превращают соединение формулы 1, определенной в п.1, в соединение формулы Iа, определенной выше, в растворителе, представляющем собой смесь ацетона и воды, в присутствии источника натрия.7. The method of producing cefotaxime sodium of formula Ia
Figure 00000004

wherein 7-ASA of the specified formula II in claim 1 is reacted with a compound of the specified formula III in claim 1 in a solvent which is a mixture of acetone and water in the presence of a base and the compound of formula 1 as defined in claim 1 is converted into a compound formula Ia, as defined above, in a solvent, which is a mixture of acetone and water, in the presence of a sodium source. 8. Способ получения натриевой соли соединения формулы I, определенной в п. 1, при котором соединение формулы II подвергают взаимодействию с соединением формулы III в присутствии неорганического основания или трет-(С1-8)алкиламина в смеси ацетон/вода; выделяют соединение формулы I, соединение формулы I подвергают реакции в присутствии источника ионов натрия в смеси ацетон/вода; и выделяют натриевую соль соединения формулы I.8. A method for producing the sodium salt of a compound of formula I as defined in claim 1, wherein the compound of formula II is reacted with a compound of formula III in the presence of an inorganic base or tert- (C 1-8 ) alkylamine in an acetone / water mixture; a compound of formula I is isolated, a compound of formula I is reacted in the presence of a source of sodium ions in an acetone / water mixture; and the sodium salt of the compound of formula I is isolated. 9. Натриевая соль соединения формулы I, определенной в п.1, в форме округлых агломератов. 9. The sodium salt of the compounds of formula I, as defined in claim 1, in the form of rounded agglomerates. 10. Натриевая соль по п.9, отличающаяся тем, что она имеет насыпную плотность от 0,2 до 0,6 г/мл. 10. Sodium salt according to claim 9, characterized in that it has a bulk density of from 0.2 to 0.6 g / ml. 11. Натриевая соль соединения формулы I, определенной в п.1, в форме игольчатых кристаллов. 11. The sodium salt of the compounds of formula I, as defined in claim 1, in the form of needle crystals.
RU97112145/04A 1994-12-23 1995-12-22 Preparation of cephotaxime and sodium salt of cephotaxime RU2169150C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0239794A AT402928B (en) 1994-12-23 1994-12-23 NEW METHOD FOR PRODUCING CEFOTAXIM
ATA2397/94 1994-12-23

Publications (2)

Publication Number Publication Date
RU97112145A true RU97112145A (en) 1999-06-27
RU2169150C2 RU2169150C2 (en) 2001-06-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU97112145/04A RU2169150C2 (en) 1994-12-23 1995-12-22 Preparation of cephotaxime and sodium salt of cephotaxime

Country Status (18)

Country Link
US (1) US5831086A (en)
EP (1) EP0799232A1 (en)
JP (1) JPH10511377A (en)
CN (1) CN1171110A (en)
AT (1) AT402928B (en)
AU (1) AU711228B2 (en)
BR (1) BR9510426A (en)
CA (1) CA2206518A1 (en)
CZ (1) CZ195097A3 (en)
FI (1) FI972265A (en)
HU (1) HUT77700A (en)
NO (1) NO972921L (en)
NZ (1) NZ298410A (en)
PL (1) PL320699A1 (en)
RU (1) RU2169150C2 (en)
SK (1) SK81597A3 (en)
TW (1) TW475932B (en)
WO (1) WO1996020198A1 (en)

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