KR870001219A - Method for preparing ceph-3-m-4-carboxylic acid derivative - Google Patents

Method for preparing ceph-3-m-4-carboxylic acid derivative Download PDF

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Publication number
KR870001219A
KR870001219A KR1019860005723A KR860005723A KR870001219A KR 870001219 A KR870001219 A KR 870001219A KR 1019860005723 A KR1019860005723 A KR 1019860005723A KR 860005723 A KR860005723 A KR 860005723A KR 870001219 A KR870001219 A KR 870001219A
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KR
South Korea
Prior art keywords
chloro
carboxylic acid
methyl
thiomethyl
isoxazol
Prior art date
Application number
KR1019860005723A
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Korean (ko)
Other versions
KR930007263B1 (en
Inventor
엘렉 산도르
마로시 카탈린
미호크 미클로스
미호크 일디코
얀크소 산도르
코바크스 이스트반
코냐 마리아
키스 일로나
렘페르트 카롤리
돌레스칼 가보르
페테르 조세프
호르냑 귤라
니트라이 조세프
시미그 귤라
자우에르 카롤리
콤보스 스잔나
Original Assignee
비오갈 교기쎄르 기아르
이스트반 체르누스, 바르나코크사르
비오갈 교기쩨르 기아르
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 비오갈 교기쎄르 기아르, 이스트반 체르누스, 바르나코크사르, 비오갈 교기쩨르 기아르 filed Critical 비오갈 교기쎄르 기아르
Publication of KR870001219A publication Critical patent/KR870001219A/en
Application granted granted Critical
Publication of KR930007263B1 publication Critical patent/KR930007263B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.No content.

Description

세프-3-엠-4-카르복실산 유도체의 제조방법Method for preparing ceph-3-m-4-carboxylic acid derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

a) 하기 일반식(III)의 3-클로로-이속사졸-아세트산 또는 그의 반응성 유도체를 하기 일반식(III)의 7-아미노-3-(1-메틸-1H-1,2,4-테트라졸-5-일)티오메틸 세프-3-엠-4-카르복실산과 반응시키고, 수득된 하기 이반식(I)의 7-(3-클로로-이속사졸-5-일)아세트아미도-3-(1-메틸-1H-1,2,3,4-테트라졸-5-일)티오메틸-세프-3-엠-4-카르복실산을 반응 혼합물로부터 분리한 후, 필요하다면, 생성된 화합물을 그의 약학적으로 수용가능한 염으로 전환시키고, 반응 혼합물로부터 염을 분리하거나; b) 하기 일반식(IV)의 1-메틸-1H-1,2,3,4-테트라졸-5-일 티올을 7-(3-클로로-이속사졸-5-일)아세트아미도-세팔로스포란산과 반응시키고, 수득된 하기 일반식(I)의 7-(3-클로로-이속사졸-5-일)아세트아미도-3-(1-메틸-1H-1,2,3,4-테트라졸-5-일)티오메틸-세프-3-엠-4-카르복실산을 반응 혼합물로부터 분리한 후, 필요하다면 생성된 화합물을 그의 약학적으로 수용 가능한 염으로 전환시키고, 반응 혼합물로부터 염을 분리함을 특징으로 하는 하기 일반식(I)의 7-(3-클로로-이속사졸-5-일)아세트아미도-3-(1-메틸-1H-1,2,3,4-테트라졸-5-일)티오메틸-세프-3-엠-4-카르복실산 및 약학적으로 수용 가능한 그의 염의 제조방법.a) 3-chloro-isoxazole-acetic acid of the following general formula (III) or a reactive derivative thereof is added to 7-amino-3- (1-methyl-1H-1,2,4-tetrazole of general formula (III) 7- (3-chloro-isoxazol-5-yl) acetamido-3- of the following general formula (I) obtained by reaction with -5-yl) thiomethyl cef-3-em-4-carboxylic acid (1-Methyl-1H-1,2,3,4-tetrazol-5-yl) thiomethyl-sef-3-m-4-carboxylic acid is separated from the reaction mixture and, if necessary, the resulting compound To a pharmaceutically acceptable salt thereof and to separate the salt from the reaction mixture; b) 1-methyl-1H-1,2,3,4-tetrazol-5-yl thiol of formula (IV) is prepared as 7- (3-chloro-isoxazol-5-yl) acetamido-cene. Reaction with palosporranic acid and obtained 7- (3-chloro-isoxazol-5-yl) acetamido-3- (1-methyl-1H-1,2,3,4 of formula (I) -Tetrazol-5-yl) thiomethyl-sef-3-m-4-carboxylic acid is separated from the reaction mixture, and if necessary the resulting compound is converted into its pharmaceutically acceptable salts and from the reaction mixture 7- (3-chloro-isoxazol-5-yl) acetamido-3- (1-methyl-1H-1,2,3,4- of formula (I) characterized by separating the salts A process for preparing tetrazol-5-yl) thiomethyl-sef-3-m-4-carboxylic acid and pharmaceutically acceptable salts thereof. 제1항에 있어서, 일반식(II)의 3-클로로-이속사졸-아세트산의 반응성 유도체로 그의 클로라이드 또는 펜티클로로페닐에스테르를 사용함을 특징으로 하는 방법.The process according to claim 1, wherein the chloride or pentichlorophenyl ester thereof is used as the reactive derivative of 3-chloro-isoxazole-acetic acid of general formula (II). ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860005723A 1985-07-16 1986-07-15 Process for preparing ceph 3-em-4-carboxylic acid derivatives KR930007263B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU2251/2725 1985-07-16
HU2725 1985-07-16
HU852725A HU203243B (en) 1985-07-16 1985-07-16 Process for producing cefalosporin derivative

Publications (2)

Publication Number Publication Date
KR870001219A true KR870001219A (en) 1987-03-12
KR930007263B1 KR930007263B1 (en) 1993-08-04

Family

ID=10960853

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860005723A KR930007263B1 (en) 1985-07-16 1986-07-15 Process for preparing ceph 3-em-4-carboxylic acid derivatives

Country Status (14)

Country Link
JP (1) JPS6222787A (en)
KR (1) KR930007263B1 (en)
CN (1) CN1012614B (en)
AT (1) AT389877B (en)
BE (1) BE905113A (en)
DE (1) DE3623900A1 (en)
FI (1) FI83877C (en)
FR (1) FR2591598B1 (en)
GB (1) GB2177696B (en)
GR (1) GR861855B (en)
HU (1) HU203243B (en)
IL (1) IL79410A0 (en)
IT (1) IT1196494B (en)
NL (1) NL8601842A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100408343B1 (en) * 2001-11-01 2003-12-06 주식회사 이앤티 Feed and manufacturing method for maintaining homeostasis of piglets

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2012729C (en) 1989-04-07 1997-05-20 Takashi Kuroda Dulled stretched molding and process for producing the same
JP2893286B2 (en) * 1990-05-17 1999-05-17 グンゼ株式会社 Heat-shrinkable foamed composite film and method for producing the same
JP2515295Y2 (en) * 1993-06-30 1996-10-30 株式会社川崎製作所 Pipe fitting

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2219775A1 (en) * 1973-03-02 1974-09-27 Gist Brocades Nv Isoxazolylacetamido penicillanic and cephalosporanic acids - partic. active against Gram-positive bacteria
JPS539787A (en) * 1976-07-16 1978-01-28 Yamanouchi Pharmaceut Co Ltd Novel cephalosporin derivatives and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100408343B1 (en) * 2001-11-01 2003-12-06 주식회사 이앤티 Feed and manufacturing method for maintaining homeostasis of piglets

Also Published As

Publication number Publication date
IT8621135A0 (en) 1986-07-15
HU203243B (en) 1991-06-28
CN86104805A (en) 1987-02-18
GB2177696A (en) 1987-01-28
GB8617181D0 (en) 1986-08-20
BE905113A (en) 1986-11-03
FR2591598A1 (en) 1987-06-19
AT389877B (en) 1990-02-12
FI83877B (en) 1991-05-31
DE3623900A1 (en) 1987-01-29
GB2177696B (en) 1989-01-05
FI83877C (en) 1991-09-10
KR930007263B1 (en) 1993-08-04
FI862965A (en) 1987-01-17
FI862965A0 (en) 1986-07-16
IL79410A0 (en) 1986-10-31
ATA192686A (en) 1989-07-15
CN1012614B (en) 1991-05-15
GR861855B (en) 1986-11-18
JPS6222787A (en) 1987-01-30
IT1196494B (en) 1988-11-16
HUT48890A (en) 1989-07-28
NL8601842A (en) 1987-02-16
FR2591598B1 (en) 1990-01-26

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