RU97103533A - DERIVATIVES OF N-SUBSTITUTED AZABICYCLOPTANE AS A NEUROLEPTIC MEANS - Google Patents
DERIVATIVES OF N-SUBSTITUTED AZABICYCLOPTANE AS A NEUROLEPTIC MEANSInfo
- Publication number
- RU97103533A RU97103533A RU97103533/04A RU97103533A RU97103533A RU 97103533 A RU97103533 A RU 97103533A RU 97103533/04 A RU97103533/04 A RU 97103533/04A RU 97103533 A RU97103533 A RU 97103533A RU 97103533 A RU97103533 A RU 97103533A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- group
- substituted
- chlorine
- compound
- Prior art date
Links
- 230000000701 neuroleptic Effects 0.000 title 1
- 239000003176 neuroleptic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 5
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005561 phenanthryl group Chemical group 0.000 claims 2
- NEOIOGUWEUTYIH-UHFFFAOYSA-N 3-azabicyclo[3.2.0]heptane Chemical class C1NCC2CCC21 NEOIOGUWEUTYIH-UHFFFAOYSA-N 0.000 claims 1
- -1 N-substituted 3-azabicyclo [3.2.0] heptanes Chemical class 0.000 claims 1
- 206010061920 Psychotic disease Diseases 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 230000000269 nucleophilic Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (4)
где R1 означает нафтильную или фенантрильную группу, которые могут быть моно- или дизамещены атомами галоида,
n означает числа 0, 1, 2, 3 или 4,
A означает остаток формул
или нафтильную группу, которая может быть замещена галоидом,
R2 означает водород, гидроксильный остаток, алкильную группу, содержащую 1-4 атома углерода, нитрогруппу или метоксигруппу или фтор, хлор, бром или иод,
R3 означает водород, фтор или хлор,
R4 означает водород или метильную группу,
R5 означает водород или хлор,
и их соли с физиологически приемлемыми кислотами.1. Derivatives of N-substituted 3-azabicyclo [3.2.0] heptanes of formula I
where R 1 means naphthyl or phenanthryl group, which can be mono - or disubstituted by halogen atoms,
n means the numbers 0, 1, 2, 3 or 4,
A means the remainder of the formulas
or naphthyl group which may be substituted by halogen,
R 2 means hydrogen, hydroxyl residue, alkyl group containing 1-4 carbon atoms, nitro group or methoxy group or fluorine, chlorine, bromine or iodine,
R 3 means hydrogen, fluorine or chlorine,
R 4 means hydrogen or methyl group,
R 5 means hydrogen or chlorine,
and their salts with physiologically acceptable acids.
Nu-(CH2)n-A,
в которой А и n имеют указанные значения и Nu означает нуклеофильную отходящую группу, подвергают взаимодействию с производным 3-азабицикло[3.2.0] гептана формулы III
где R1 означает нафтильную или фенантрильную группу, которые могут быть моно- или дизамещены атомом галоида,
и полученное таким образом соединение в случае необходимости переводят в соль с помощью физиологически приемлемой кислоты.4. The method of producing compounds of formula I according to claim 1, characterized in that the compound of formula II
Nu- (CH 2 ) n -A,
in which A and n have the indicated meanings and Nu means a nucleophilic leaving group, is reacted with a 3-azabicyclo [3.2.0] heptane derivative of formula III
where R 1 means naphthyl or phenanthryl group, which can be mono - or disubstituted by a halogen atom,
and the compound thus obtained is salified, if necessary, with a physiologically acceptable acid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4427647A DE4427647A1 (en) | 1994-08-04 | 1994-08-04 | N-substituted azabicycloheptane derivatives, their preparation and use |
| DEP4427647.8 | 1994-08-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97103533A true RU97103533A (en) | 1999-06-10 |
| RU2160254C2 RU2160254C2 (en) | 2000-12-10 |
Family
ID=6524943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97103533/04A RU2160254C2 (en) | 1994-08-04 | 1995-07-22 | N-substituted 3-azabicyclo (3 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5753690A (en) |
| EP (1) | EP0775113B1 (en) |
| JP (1) | JPH10503504A (en) |
| KR (1) | KR970704685A (en) |
| CN (1) | CN1064959C (en) |
| AT (1) | ATE200482T1 (en) |
| AU (1) | AU699021B2 (en) |
| BG (1) | BG63632B1 (en) |
| CA (1) | CA2196700A1 (en) |
| CZ (1) | CZ289080B6 (en) |
| DE (2) | DE4427647A1 (en) |
| DK (1) | DK0775113T3 (en) |
| ES (1) | ES2156212T3 (en) |
| FI (1) | FI970449A (en) |
| GR (1) | GR3035744T3 (en) |
| HR (1) | HRP950437B1 (en) |
| HU (1) | HUT77768A (en) |
| IL (1) | IL114719A (en) |
| MX (1) | MX9700854A (en) |
| NO (1) | NO307376B1 (en) |
| NZ (1) | NZ290429A (en) |
| PL (1) | PL182810B1 (en) |
| PT (1) | PT775113E (en) |
| RU (1) | RU2160254C2 (en) |
| SI (1) | SI9520086B (en) |
| TW (1) | TW378203B (en) |
| UA (1) | UA44736C2 (en) |
| WO (1) | WO1996004245A1 (en) |
| ZA (1) | ZA956476B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19836406A1 (en) | 1998-08-12 | 2000-02-17 | Basf Ag | New S,S-dioxobenzisothiazolinyl-substituted 3-azabicyclo (3.2.0) heptane derivatives, useful e.g. as neuroleptics, antidepressants, hypnotics and sedatives |
| US6458821B1 (en) | 1998-08-12 | 2002-10-01 | Abbott Laboratories | N-substituted azabicycloheptane derivatives, production and use thereof |
| DE19836404A1 (en) * | 1998-08-12 | 2000-02-17 | Basf Ag | New benzimidazolonyl-substituted 3-azabicyclo (3.2.0) heptane derivatives, useful e.g. as neuroleptics, antidepressants, hypnotics and sedatives |
| DE19854147A1 (en) * | 1998-11-24 | 2000-05-25 | Basf Ag | Control of cocaine addiction comprises administration of N-substituted azabicycloalkane derivative |
| EP1812389B1 (en) * | 2004-10-14 | 2011-08-17 | Abbott GmbH & Co. KG | Azabicycloheptyl compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
| WO2006096757A2 (en) * | 2005-03-07 | 2006-09-14 | The University Of North Carolina At Chapel Hill | Inhibitors of reca activities for control of antibiotic-resistant bacterial pathogens |
| FR2953514B1 (en) * | 2009-12-09 | 2011-12-23 | Servier Lab | NOVEL AZABICYCLO [3.2.0] HEPT-3-YL DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| CN112010859B (en) * | 2019-05-30 | 2022-07-19 | 中国科学院上海药物研究所 | Fused ring compound, preparation method and application thereof |
| CN118356426A (en) * | 2023-01-18 | 2024-07-19 | 苏州旺山旺水生物医药股份有限公司 | Pharmaceutical composition containing fused ring compound and preparation method and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4219973A1 (en) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
| DE4243287A1 (en) * | 1992-06-19 | 1993-12-23 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
| GB9321481D0 (en) * | 1993-10-18 | 1993-12-08 | Alcan Int Ltd | Tin oxide |
| DE4341402A1 (en) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituted azabicycloheptane derivatives, their preparation and use |
-
1994
- 1994-08-04 DE DE4427647A patent/DE4427647A1/en not_active Withdrawn
-
1995
- 1995-07-22 SI SI9520086A patent/SI9520086B/en unknown
- 1995-07-22 AU AU31165/95A patent/AU699021B2/en not_active Ceased
- 1995-07-22 DE DE59509186T patent/DE59509186D1/en not_active Expired - Fee Related
- 1995-07-22 JP JP8506150A patent/JPH10503504A/en not_active Ceased
- 1995-07-22 UA UA97030905A patent/UA44736C2/en unknown
- 1995-07-22 US US08/776,583 patent/US5753690A/en not_active Expired - Lifetime
- 1995-07-22 PT PT95926973T patent/PT775113E/en unknown
- 1995-07-22 NZ NZ290429A patent/NZ290429A/en unknown
- 1995-07-22 ES ES95926973T patent/ES2156212T3/en not_active Expired - Lifetime
- 1995-07-22 CA CA002196700A patent/CA2196700A1/en not_active Abandoned
- 1995-07-22 EP EP95926973A patent/EP0775113B1/en not_active Expired - Lifetime
- 1995-07-22 AT AT95926973T patent/ATE200482T1/en not_active IP Right Cessation
- 1995-07-22 CN CN951949071A patent/CN1064959C/en not_active Expired - Fee Related
- 1995-07-22 RU RU97103533/04A patent/RU2160254C2/en active
- 1995-07-22 CZ CZ1997311A patent/CZ289080B6/en not_active IP Right Cessation
- 1995-07-22 MX MX9700854A patent/MX9700854A/en not_active IP Right Cessation
- 1995-07-22 KR KR1019970700754A patent/KR970704685A/en not_active Application Discontinuation
- 1995-07-22 WO PCT/EP1995/002912 patent/WO1996004245A1/en active IP Right Grant
- 1995-07-22 DK DK95926973T patent/DK0775113T3/en active
- 1995-07-22 HU HU9700330A patent/HUT77768A/en unknown
- 1995-07-25 IL IL11471995A patent/IL114719A/en not_active IP Right Cessation
- 1995-07-27 TW TW084107778A patent/TW378203B/en not_active IP Right Cessation
- 1995-08-03 ZA ZA9506476A patent/ZA956476B/en unknown
- 1995-08-04 HR HR950437A patent/HRP950437B1/en not_active IP Right Cessation
-
1997
- 1997-02-03 NO NO970474A patent/NO307376B1/en not_active IP Right Cessation
- 1997-02-03 FI FI970449A patent/FI970449A/en unknown
- 1997-02-12 BG BG101221A patent/BG63632B1/en unknown
- 1997-03-04 PL PL95318459A patent/PL182810B1/en unknown
-
2001
- 2001-04-12 GR GR20010400486T patent/GR3035744T3/en not_active IP Right Cessation
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