RU96105070A - METHOD OF CRYSTALLIZING IOPAMIDOL - Google Patents

METHOD OF CRYSTALLIZING IOPAMIDOL

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Publication number
RU96105070A
RU96105070A RU96105070/04A RU96105070A RU96105070A RU 96105070 A RU96105070 A RU 96105070A RU 96105070/04 A RU96105070/04 A RU 96105070/04A RU 96105070 A RU96105070 A RU 96105070A RU 96105070 A RU96105070 A RU 96105070A
Authority
RU
Russia
Prior art keywords
butanol
iopamidol
isobutanol
tert
sec
Prior art date
Application number
RU96105070/04A
Other languages
Russian (ru)
Other versions
RU2135462C1 (en
Inventor
Вилла Марко
Паиоччи Маурицио
Original Assignee
Замбон Груп С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI931720A external-priority patent/IT1257001B/en
Priority claimed from IT000760 external-priority patent/IT1269339B/en
Application filed by Замбон Груп С.П.А. filed Critical Замбон Груп С.П.А.
Priority claimed from PCT/EP1994/002415 external-priority patent/WO1995004031A1/en
Publication of RU96105070A publication Critical patent/RU96105070A/en
Application granted granted Critical
Publication of RU2135462C1 publication Critical patent/RU2135462C1/en

Links

Claims (23)

1. Способ кристаллизации иопамидола, в котором используют н-бутанол, втор-бутанол, изобутанол или трет-бутанол.1. A crystallization method of iopamidol using n-butanol, sec-butanol, isobutanol or tert-butanol. 2. Способ по п. 1, в котором используют н-бутанол. 2. The method of claim 1, wherein n-butanol is used. 3. Способ по п. 1, в котором используют втор-бутанол. 3. The method of claim 1, wherein sec-butanol is used. 4. Способ по п. 1, в котором используют изобутанол. 4. The method of claim 1, wherein isobutanol is used. 5. Способ по п. 1, в котором используют трет-бутанол. 5. The method of claim 1, wherein tert-butanol is used. 6. Способ по п. 1, включающий кристаллизацию твердого сырого иопамидола из н-бутанола, втор-бутанола, изобутанола или трет-бутанола. 6. The method according to p. 1, including the crystallization of solid crude iopamidol from n-butanol, sec-butanol, isobutanol or tert-butanol. 7. Способ по п. 6, в котором кристаллизацию проводят из н-бутанола. 7. The method according to p. 6, in which crystallization is carried out from n-butanol. 8. Способ по п. 6, в котором кристаллизацию проводят из втор-бутанола. 8. The method according to p. 6, in which crystallization is carried out from sec-butanol. 9. Способ по п. 6, в котором кристаллизацию проводят из изобутанола. 9. The method according to p. 6, in which crystallization is carried out from isobutanol. 10. Способ по п. 6, в котором кристаллизацию проводят из трет-бутанола. 10. The method according to p. 6, in which crystallization is carried out from tert-butanol. 11. Способ по п. 1, включающий обработку водного раствора иопамидола н-бутанолом, втор-бутанолом, изобутанолом или трет-бутанолом. 11. The method according to p. 1, comprising treating an aqueous solution of iopamidol with n-butanol, sec-butanol, isobutanol or tert-butanol. 12. Способ по п. 11, в котором используют н-бутанол. 12. The method of claim 11, wherein n-butanol is used. 13. Способ по п. 11, в котором используют втор-бутанол. 13. The method of claim 11, wherein sec-butanol is used. 14. Способ по п. 11, в котором используют изобутанол. 14. The method of claim 11, wherein isobutanol is used. 15. Способ по п. 11, в котором используют трет-бутанол. 15. The method of claim 11, wherein tert-butanol is used. 16. Способ по п. 11, в котором используют водный раствор иопамидола, получаемый на предшествующих стадиях синтеза или очистки продукта. 16. The method according to p. 11, which uses an aqueous solution of iopamidol obtained in the previous stages of synthesis or purification of the product. 17. Способ по п. 11, в котором количество н-бутанола, втор-бутанола, изобутанола или трет-бутанола в 3 - 20 раз в отношении объема к массе превышает количество иопамидола, содержащегося в водном растворе. 17. The method according to p. 11, in which the amount of n-butanol, sec-butanol, isobutanol or tert-butanol is 3 to 20 times the volume to mass ratio exceeds the amount of iopamidol contained in the aqueous solution. 18. Способ по п. 11, в котором смесь воды, иопамидола и либо н-бутанола, либо втор-бутанола, либо изобутанола, либо трет-бутанола нагревают до кипения для частичного или полного удаления содержащейся воды. 18. The method of claim 11, wherein the mixture of water, iopamidol and either n-butanol, or sec-butanol, or isobutanol, or tert-butanol is heated to boiling to partially or completely remove the contained water. 19. Способ по п. 11, в котором в смесь воды, иопамидола и либо н-бутанола, либо втор-бутанола, либо изобутанола, либо трет-бутанола добавляют растворитель, способный образовывать трехкомпонентную азеотропную смесь. 19. The method according to p. 11, in which a solvent capable of forming a three-component azeotropic mixture is added to a mixture of water, iopamidol and either n-butanol or sec-butanol or isobutanol or tert-butanol. 20. Способ по п. 19, в котором растворителем, способным образовывать трехкомпонентную азеотропную смесь, служит толуол. 20. The method according to p. 19, in which the solvent capable of forming a three-component azeotropic mixture is toluene. 21. Способ по пп. 19 и 20, отличающийся тем, что остаточное содержание растворителя ниже 5000 ч./млн. 21. The method according to PP. 19 and 20, characterized in that the residual solvent content is below 5000 ppm. 22. Кристаллический иопамидол, полученный по пп. 1 - 21. 22. Crystalline iopamidol obtained in paragraphs. 1 - 21. 23. Неионогенное контрастное средство, содержащее эффективное количество кристаллического иопамидола по пп. 1 - 21. 23. Non-ionic contrast agent containing an effective amount of crystalline iopamidol according to paragraphs. 1 - 21.
RU96105070A 1993-07-30 1994-07-22 Method of crystallizing iopamidol RU2135462C1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
ITMI931720A IT1257001B (en) 1993-07-30 1993-07-30 Process for the crystallisation of iopamidol
ITMI93A001720 1993-07-30
ITM193A001720 1993-07-30
ITMI94A000760 1994-04-20
IT000760 IT1269339B (en) 1994-04-20 1994-04-20 Crystalline Iopamidol used as nonionic contrast medium - is crystallised from normal, sec, iso and/or tert butanol.
ITM194A000760 1994-04-20
PCT/EP1994/002415 WO1995004031A1 (en) 1993-07-30 1994-07-22 Process for the crystallization of iopamidol

Publications (2)

Publication Number Publication Date
RU96105070A true RU96105070A (en) 1998-06-10
RU2135462C1 RU2135462C1 (en) 1999-08-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU96105070A RU2135462C1 (en) 1993-07-30 1994-07-22 Method of crystallizing iopamidol

Country Status (29)

Country Link
US (3) US5571941A (en)
JP (1) JP3299045B2 (en)
KR (1) KR100355211B1 (en)
CN (1) CN1035940C (en)
AT (1) AT404832B (en)
AU (1) AU690138B2 (en)
BE (1) BE1008403A4 (en)
CA (1) CA2128942C (en)
CH (1) CH686783A5 (en)
CZ (1) CZ289300B6 (en)
DE (1) DE4426818A1 (en)
DK (1) DK172074B1 (en)
ES (1) ES2102312B1 (en)
FI (1) FI960400A0 (en)
FR (1) FR2708601B1 (en)
GB (1) GB2280436B (en)
GR (1) GR940100366A (en)
HU (1) HU217023B (en)
IE (1) IE80675B1 (en)
IL (1) IL110391A (en)
NL (1) NL194272C (en)
NO (1) NO304226B1 (en)
NZ (1) NZ271632A (en)
PT (1) PT101554B (en)
RU (1) RU2135462C1 (en)
SE (1) SE9402595L (en)
SI (1) SI9420046B (en)
WO (1) WO1995004031A1 (en)
ZA (1) ZA945472B (en)

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KR100758741B1 (en) * 1997-02-11 2007-09-14 브라코 인터내셔날 비이.브이. Process for the Crystallization from a Linear or Branched C5-C6 Alcohol or Their Mixtures of S-N,N'-bis[2-Hydroxy-1-hydroxymethylethyl]-5-[2-hydroxy-1-oxopropylamino]-2,4,6-triiodo-1,3-benzendicarboxamine
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
KR20000031642A (en) * 1998-11-09 2000-06-05 강재헌 Method for crystallization of iopamidol
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
IT1319671B1 (en) 2000-12-01 2003-10-23 Bracco Spa PROCESS FOR THE PREPARATION OF (S) -N, N'-BIS (2-IDROSSI-1- (IDROSSIMETIL) ETIL) -5 - ((2-IDROSSI-1-OSSOPROPIL) AMINO)
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KR100976097B1 (en) * 2008-12-05 2010-08-16 주식회사 대웅제약 Method for selective crystallization of iopromide z isomer
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DE102012104679A1 (en) 2011-05-30 2012-12-06 Westfälische Wilhelms-Universität Münster Preparing 2-amino-1,3-propanediol (serinol) starting from a substrate containing glycerol, comprises converting glycerol by a dihydroxyacetone-phosphate aminotransferase/dihydro rhizobitoxin synthase, or its portion
CN104854080B (en) * 2012-12-19 2018-07-03 通用电气医疗集团股份有限公司 The purifying of x-ray contrast agent
KR102128423B1 (en) * 2018-09-17 2020-07-01 (주)유케이케미팜 Process for the proparation of contrast medium iomeprol

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