RU96105070A - METHOD OF CRYSTALLIZING IOPAMIDOL - Google Patents
METHOD OF CRYSTALLIZING IOPAMIDOLInfo
- Publication number
- RU96105070A RU96105070A RU96105070/04A RU96105070A RU96105070A RU 96105070 A RU96105070 A RU 96105070A RU 96105070/04 A RU96105070/04 A RU 96105070/04A RU 96105070 A RU96105070 A RU 96105070A RU 96105070 A RU96105070 A RU 96105070A
- Authority
- RU
- Russia
- Prior art keywords
- butanol
- iopamidol
- isobutanol
- tert
- sec
- Prior art date
Links
- 229960004647 Iopamidol Drugs 0.000 title claims 10
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 title claims 10
- BTANRVKWQNVYAZ-UHFFFAOYSA-N 2-Butanol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 claims 18
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N Isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 18
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 18
- DKGAVHZHDRPRBM-UHFFFAOYSA-N t-BuOH Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 18
- 238000002425 crystallisation Methods 0.000 claims 6
- 230000005712 crystallization Effects 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000009835 boiling Methods 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000002194 synthesizing Effects 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Substances CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
Claims (23)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI931720A IT1257001B (en) | 1993-07-30 | 1993-07-30 | Process for the crystallisation of iopamidol |
ITMI93A001720 | 1993-07-30 | ||
ITM193A001720 | 1993-07-30 | ||
ITMI94A000760 | 1994-04-20 | ||
IT000760 IT1269339B (en) | 1994-04-20 | 1994-04-20 | Crystalline Iopamidol used as nonionic contrast medium - is crystallised from normal, sec, iso and/or tert butanol. |
ITM194A000760 | 1994-04-20 | ||
PCT/EP1994/002415 WO1995004031A1 (en) | 1993-07-30 | 1994-07-22 | Process for the crystallization of iopamidol |
Publications (2)
Publication Number | Publication Date |
---|---|
RU96105070A true RU96105070A (en) | 1998-06-10 |
RU2135462C1 RU2135462C1 (en) | 1999-08-27 |
Family
ID=26331032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96105070A RU2135462C1 (en) | 1993-07-30 | 1994-07-22 | Method of crystallizing iopamidol |
Country Status (29)
Country | Link |
---|---|
US (3) | US5571941A (en) |
JP (1) | JP3299045B2 (en) |
KR (1) | KR100355211B1 (en) |
CN (1) | CN1035940C (en) |
AT (1) | AT404832B (en) |
AU (1) | AU690138B2 (en) |
BE (1) | BE1008403A4 (en) |
CA (1) | CA2128942C (en) |
CH (1) | CH686783A5 (en) |
CZ (1) | CZ289300B6 (en) |
DE (1) | DE4426818A1 (en) |
DK (1) | DK172074B1 (en) |
ES (1) | ES2102312B1 (en) |
FI (1) | FI960400A0 (en) |
FR (1) | FR2708601B1 (en) |
GB (1) | GB2280436B (en) |
GR (1) | GR940100366A (en) |
HU (1) | HU217023B (en) |
IE (1) | IE80675B1 (en) |
IL (1) | IL110391A (en) |
NL (1) | NL194272C (en) |
NO (1) | NO304226B1 (en) |
NZ (1) | NZ271632A (en) |
PT (1) | PT101554B (en) |
RU (1) | RU2135462C1 (en) |
SE (1) | SE9402595L (en) |
SI (1) | SI9420046B (en) |
WO (1) | WO1995004031A1 (en) |
ZA (1) | ZA945472B (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the crystallization of iopamidol |
US6310243B1 (en) * | 1994-09-23 | 2001-10-30 | Nycomed Imaging As | Iodinated x-ray contrast media |
PT101720A (en) * | 1995-06-08 | 1997-01-31 | Hovione Sociedade Quimica S A | PROCESS FOR THE PURIFICATION AND CRYSTALLIZATION OF IOPAMIDOL |
EP0842141A1 (en) * | 1995-07-04 | 1998-05-20 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylen-glycol |
ATE187437T1 (en) * | 1995-09-08 | 1999-12-15 | Bracco Int Bv | METHOD FOR CRYSTALLIZATION FROM WATER OF (S)-N,N'-BIS(2-HYDROXY-1-(HYDROXYMETHIEL)ETHYL>5-((2-HYDROXY-1-OXOPROPYL)AMINO>-2,4,6-TRIIODO - ,3- BENZOLDICARBOXAMIDE |
PT101919B (en) * | 1996-09-30 | 2000-01-31 | Hovione Sociedade Quimica Sa | A PROCESS FOR THE PURIFICATION OF TOHEXOL |
KR100758741B1 (en) * | 1997-02-11 | 2007-09-14 | 브라코 인터내셔날 비이.브이. | Process for the Crystallization from a Linear or Branched C5-C6 Alcohol or Their Mixtures of S-N,N'-bis[2-Hydroxy-1-hydroxymethylethyl]-5-[2-hydroxy-1-oxopropylamino]-2,4,6-triiodo-1,3-benzendicarboxamine |
GB9720969D0 (en) * | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
KR20000031642A (en) * | 1998-11-09 | 2000-06-05 | 강재헌 | Method for crystallization of iopamidol |
US6265610B1 (en) | 1999-01-12 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Contrast media for angiography |
US6803485B2 (en) | 1999-02-26 | 2004-10-12 | Bracco Imaging S.P.A. | Process for the preparation of iopamidol |
IT1319671B1 (en) | 2000-12-01 | 2003-10-23 | Bracco Spa | PROCESS FOR THE PREPARATION OF (S) -N, N'-BIS (2-IDROSSI-1- (IDROSSIMETIL) ETIL) -5 - ((2-IDROSSI-1-OSSOPROPIL) AMINO) |
DE102005059191B4 (en) * | 2005-12-05 | 2008-02-07 | Bayer Schering Pharma Ag | Process for the recovery of pharmaceutically acceptable iopromide from mother liquors |
KR100976097B1 (en) * | 2008-12-05 | 2010-08-16 | 주식회사 대웅제약 | Method for selective crystallization of iopromide z isomer |
AU2010232556A1 (en) * | 2009-04-02 | 2011-11-03 | Allergan, Inc. | Prostaglandin E receptor antagonists |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
DE102012104679A1 (en) | 2011-05-30 | 2012-12-06 | Westfälische Wilhelms-Universität Münster | Preparing 2-amino-1,3-propanediol (serinol) starting from a substrate containing glycerol, comprises converting glycerol by a dihydroxyacetone-phosphate aminotransferase/dihydro rhizobitoxin synthase, or its portion |
CN104854080B (en) * | 2012-12-19 | 2018-07-03 | 通用电气医疗集团股份有限公司 | The purifying of x-ray contrast agent |
KR102128423B1 (en) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | Process for the proparation of contrast medium iomeprol |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH608189A5 (en) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
IT1193211B (en) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | 2,4,6-TRIIODE-ISOPHTHALIC ACID DERIVATIVES, METHOD FOR THEIR PREPARATION AND CONTRAST MEANS THAT CONTAIN THEM |
DE3150916A1 (en) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-HYDROXYAETHYLATED 2,4,6-TRIJODAMINOISIOPHTHALIC ACID-BISTRIHYDROXYBUTYLAMIDES, THEIR PRODUCTION AND THEIR CONTAINING X-RAY CONTRASTING AGENTS " |
US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
NZ224743A (en) * | 1987-05-22 | 1991-07-26 | Bracco Ind Chimica Spa | 5-acylamino-2,4,6-tribromo- or triiodo-benzoic acid derivatives and intermediate compounds used in their preparation |
IT1248741B (en) * | 1991-02-26 | 1995-01-26 | Bracco Spa | CONCENTRATION AND PURIFICATION PROCESS OF ORGANIC COMPOUNDS |
IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the crystallization of iopamidol |
-
1994
- 1994-07-20 IL IL11039194A patent/IL110391A/en not_active IP Right Cessation
- 1994-07-22 WO PCT/EP1994/002415 patent/WO1995004031A1/en active Application Filing
- 1994-07-22 RU RU96105070A patent/RU2135462C1/en active
- 1994-07-22 HU HU9600191A patent/HU217023B/en unknown
- 1994-07-22 CN CN94192930A patent/CN1035940C/en not_active Expired - Lifetime
- 1994-07-22 SI SI9420046A patent/SI9420046B/en unknown
- 1994-07-22 KR KR1019960700580A patent/KR100355211B1/en not_active IP Right Cessation
- 1994-07-22 NZ NZ271632A patent/NZ271632A/en not_active IP Right Cessation
- 1994-07-22 GR GR940100366A patent/GR940100366A/en unknown
- 1994-07-22 AU AU75321/94A patent/AU690138B2/en not_active Expired
- 1994-07-25 GB GB9414912A patent/GB2280436B/en not_active Expired - Lifetime
- 1994-07-25 ZA ZA945472A patent/ZA945472B/en unknown
- 1994-07-26 CH CH02354/94A patent/CH686783A5/en not_active IP Right Cessation
- 1994-07-26 NL NL9401229A patent/NL194272C/en not_active IP Right Cessation
- 1994-07-26 PT PT101554A patent/PT101554B/en not_active IP Right Cessation
- 1994-07-26 FR FR9409238A patent/FR2708601B1/en not_active Expired - Lifetime
- 1994-07-27 CA CA002128942A patent/CA2128942C/en not_active Expired - Lifetime
- 1994-07-28 DE DE4426818A patent/DE4426818A1/en not_active Ceased
- 1994-07-29 JP JP17811594A patent/JP3299045B2/en not_active Expired - Lifetime
- 1994-07-29 DK DK089294A patent/DK172074B1/en not_active IP Right Cessation
- 1994-07-29 CZ CZ19941831A patent/CZ289300B6/en not_active IP Right Cessation
- 1994-07-29 SE SE9402595A patent/SE9402595L/en not_active Application Discontinuation
- 1994-07-29 ES ES09401679A patent/ES2102312B1/en not_active Expired - Fee Related
- 1994-07-29 AT AT0150594A patent/AT404832B/en not_active IP Right Cessation
- 1994-07-29 BE BE9400717A patent/BE1008403A4/en not_active IP Right Cessation
- 1994-07-29 IE IE940609A patent/IE80675B1/en not_active IP Right Cessation
- 1994-07-29 US US08/281,985 patent/US5571941A/en not_active Ceased
-
1996
- 1996-01-29 FI FI960400A patent/FI960400A0/en not_active Application Discontinuation
- 1996-01-29 NO NO960376A patent/NO304226B1/en not_active IP Right Cessation
-
1997
- 1997-02-07 US US08/797,610 patent/USRE36433E/en not_active Expired - Lifetime
-
1998
- 1998-08-25 US US09/139,894 patent/US6506938B1/en not_active Expired - Lifetime
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