RU96103640A - CRATAEGUS DRUG AND PHARMACEUTICAL COMPOSITION FOR PREVENTING ACCIDENTAL DEATH AS A RESULT OF STOPPING OF THE HEART AND CARDIOVASCULAR INJURIES CAUSED BY REPERFUSION - Google Patents

CRATAEGUS DRUG AND PHARMACEUTICAL COMPOSITION FOR PREVENTING ACCIDENTAL DEATH AS A RESULT OF STOPPING OF THE HEART AND CARDIOVASCULAR INJURIES CAUSED BY REPERFUSION

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Publication number
RU96103640A
RU96103640A RU96103640/14A RU96103640A RU96103640A RU 96103640 A RU96103640 A RU 96103640A RU 96103640/14 A RU96103640/14 A RU 96103640/14A RU 96103640 A RU96103640 A RU 96103640A RU 96103640 A RU96103640 A RU 96103640A
Authority
RU
Russia
Prior art keywords
crataegus
reperfusion
varieties
flowers
ethanol
Prior art date
Application number
RU96103640/14A
Other languages
Russian (ru)
Other versions
RU2126261C1 (en
Inventor
Схиам Зандер ХАТТЕРЬЕ
Герман Эрнст ЯГГИ
Original Assignee
Вилмар Швабе ГмбХ и Ко.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4325532A external-priority patent/DE4325532A1/en
Application filed by Вилмар Швабе ГмбХ и Ко. filed Critical Вилмар Швабе ГмбХ и Ко.
Publication of RU96103640A publication Critical patent/RU96103640A/en
Application granted granted Critical
Publication of RU2126261C1 publication Critical patent/RU2126261C1/en

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Claims (7)

1. Препарат из Cratаеgus, отличающийся тем, что он получен экстракцией листьев с цветами разновидностей Crataegus с 45 мас.% этанола при 60°С и ультрафильтрацией полученного полного экстракта через мембранный фильтр с порогом отрезания 3000 Дальтон.1. A preparation from Crataegus, characterized in that it is obtained by extracting leaves with flowers of varieties of Crataegus with 45 wt.% Ethanol at 60 ° C and ultrafiltration of the obtained complete extract through a membrane filter with a cut-off threshold of 3000 Daltons. 2. Препарат из Crataegus, отличающийся тем, что он получен экстракцией листьев с цветами разновидностей Crataegus с 45 мас.% этанола при 60°С и отделением низкомолекулярных компонентов распределением жидкость-жидкость полученного полного экстракта в бутаноле/воде. 2. A preparation from Crataegus, characterized in that it is obtained by extraction of leaves with flowers of varieties of Crataegus with 45 wt.% Ethanol at 60 ° C and separation of low molecular weight components by liquid-liquid distribution of the obtained complete extract in butanol / water. 3. Препарат из Crataegus, отличающийся тем, что он получен экстракцией листьев с цветами разновидностей Crataegus с 45 мас.% этанола при 60 С и гелевой фильтрацией полученного полного экстракта для отделения флавоноидов и проантоцианидинов. 3. A preparation from Crataegus, characterized in that it is obtained by extracting leaves with flowers of varieties of Crataegus with 45 wt.% Ethanol at 60 ° C and gel filtration of the resulting extract to separate flavonoids and proanthocyanidins. 4. Препарат из Crataegus, отличающийся тем, что он получен экстракцией листьев с цветами разновидностей Crataegus с 45 мас. % этанола при 60oC и абсорбцией флавоноидов и процианидинов, присутствующих в полученном полном экстракте, на поглотителе, способном к связыванию этих компонентов.4. The drug from Crataegus, characterized in that it is obtained by extraction of leaves with flowers of varieties of Crataegus with 45 wt. % ethanol at 60 o C and the absorption of flavonoids and procyanidins present in the resulting complete extract, on an absorber capable of binding these components. 5. Фармацевтический состав, отличающийся тем, что он содержит один из препаратов в соответствии с пп. 1 - 4. 5. The pharmaceutical composition, characterized in that it contains one of the drugs in accordance with paragraphs. fourteen. 6. Состав по п. 5, отличающийся тем, что он предназначен для предотвращения внезапной смерти в результате остановки сердца и вызванных реперфузией сердечно-сосудистых поражений и других вызванных реперфузией угрожающих жизни патологических условий. 6. The composition according to p. 5, characterized in that it is intended to prevent sudden death due to cardiac arrest and reperfusion-induced cardiovascular lesions and other life-threatening pathological conditions caused by reperfusion. 7. Применение полного экстракта, полученного экстракцией листьев с цветами разновидностей Crataegus водой, ацетоном, алканолом C1 - C4 или смесями воды и указанных растворимых в воде органических растворителей, для предотвращения внезапной смерти в результате остановки сердца и вызванных реперфузией сердечно-сосудистых поражений и других вызванных реперфузией угрожающих жизни патологических условий.7. The use of a complete extract obtained by extracting leaves with the colors of Crataegus varieties with water, acetone, C 1 -C 4 alkanol or mixtures of water and the indicated water-soluble organic solvents, to prevent sudden death due to cardiac arrest and reperfusion of cardiovascular lesions and other life-threatening pathological conditions caused by reperfusion.
RU96103640A 1993-07-29 1994-07-28 Crataegus preparation and pharmaceutical composition for preventing sudden death resulting from heart failure and reperfusion-caused cardiovascular affection RU2126261C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4325532A DE4325532A1 (en) 1993-07-29 1993-07-29 Preparations of Crataegus species, medicinal products and their use for the prevention of sudden cardiac death and reperfusion-related cardiovascular damage
DEP4325532.9 1993-07-29
PCT/EP1994/002497 WO1995003816A1 (en) 1993-07-29 1994-07-28 Compositions of crataegus species, medicaments and their use for preventing sudden death due to cardiac arrest and reperfusion-caused cardiovascular lesions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU98114685/14A Division RU2162704C2 (en) 1993-07-29 1994-07-28 Crataegus extract as preparation for prevention of sudden death as result of heart stop and cardiovascular damages induced by reperfusion

Publications (2)

Publication Number Publication Date
RU96103640A true RU96103640A (en) 1998-05-20
RU2126261C1 RU2126261C1 (en) 1999-02-20

Family

ID=6494034

Family Applications (2)

Application Number Title Priority Date Filing Date
RU96103640A RU2126261C1 (en) 1993-07-29 1994-07-28 Crataegus preparation and pharmaceutical composition for preventing sudden death resulting from heart failure and reperfusion-caused cardiovascular affection
RU98114685/14A RU2162704C2 (en) 1993-07-29 1994-07-28 Crataegus extract as preparation for prevention of sudden death as result of heart stop and cardiovascular damages induced by reperfusion

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU98114685/14A RU2162704C2 (en) 1993-07-29 1994-07-28 Crataegus extract as preparation for prevention of sudden death as result of heart stop and cardiovascular damages induced by reperfusion

Country Status (11)

Country Link
US (1) US5925355A (en)
EP (1) EP0711172B1 (en)
JP (1) JP3345660B2 (en)
KR (1) KR960703611A (en)
CN (1) CN1083267C (en)
AT (1) ATE147631T1 (en)
CA (1) CA2168246C (en)
DE (2) DE4325532A1 (en)
ES (1) ES2086274T3 (en)
RU (2) RU2126261C1 (en)
WO (1) WO1995003816A1 (en)

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US5554645A (en) * 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same
US5702752A (en) * 1996-03-13 1997-12-30 Archer Daniels Midland Company Production of isoflavone enriched fractions from soy protein extracts
US6261565B1 (en) 1996-03-13 2001-07-17 Archer Daniels Midland Company Method of preparing and using isoflavones
US6391310B1 (en) 1996-03-13 2002-05-21 Archer Daniels Midland Company Method of preparing and using isoflavones for the treatment of neurological symptoms
US6297273B1 (en) * 1996-04-02 2001-10-02 Mars, Inc. Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
DE19740509A1 (en) * 1997-09-15 1999-03-18 Robugen Gmbh Use of a hawthorn fruit and / or leaf / flower extract
AUPP254598A0 (en) * 1998-03-23 1998-04-23 Quality Wheat Crc Limited Food colouring and method for producing same
US6746695B1 (en) 1998-10-02 2004-06-08 Armadillo Pharmaceuticals, Inc. Pharmaceutical preparations of bioactive substances extracted from natural sources
KR100441741B1 (en) * 2001-09-07 2004-07-23 한영환 Improved methods of mycelial culture of Phellinus linteus KCTC 10055BP for increasing anti-oxidanic effects
US7514107B2 (en) * 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
AU2003226617A1 (en) * 2003-03-26 2004-10-18 Council Of Scientific And Industrial Research Nontoxic dental care herbal formulation for preventing dental plaque and gingivitis
US7911218B2 (en) * 2003-12-22 2011-03-22 Robert Bosch Gmbh Device and method for analyzing a sample plate

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US2799618A (en) * 1955-04-07 1957-07-16 Hausmann Lab Ltd Glycosidal material having activity on the heart and vascular vessels and its preparation from plant sources
DE1103519B (en) * 1959-08-06 1961-03-30 Madaus & Co Dr Process for the production of hawthorn extracts
BG21942A2 (en) * 1975-06-21 1977-05-20
US5064675A (en) * 1991-03-01 1991-11-12 Scandinavian Natural Resources Development Hb Herbal extract composition
CN1039782C (en) * 1991-12-11 1998-09-16 陕西省西安植物园 Process for extracting crataegolic flavone from hawthorn leaves
CN1064294A (en) * 1992-03-25 1992-09-09 鞍山市树脂厂 Heat-resistant black organic silicon paint for dining utensil and manufacture method

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