DE1103519B - Process for the production of hawthorn extracts - Google Patents

Process for the production of hawthorn extracts

Info

Publication number
DE1103519B
DE1103519B DEM42366A DEM0042366A DE1103519B DE 1103519 B DE1103519 B DE 1103519B DE M42366 A DEM42366 A DE M42366A DE M0042366 A DEM0042366 A DE M0042366A DE 1103519 B DE1103519 B DE 1103519B
Authority
DE
Germany
Prior art keywords
hawthorn
production
extraction
extracts
hawthorn extracts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEM42366A
Other languages
German (de)
Inventor
Dr Rolf Madaus
Dr Alfred Kuhn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Dr Madaus GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co
Priority to DEM42366A priority Critical patent/DE1103519B/en
Publication of DE1103519B publication Critical patent/DE1103519B/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Description

Die Erfindung betrifft ein Verfahren zur Herstellung eines Arzneimittels auf der Basis von Weißdornauszügen. Es ist bekannt, daß pflanzliche Extrakte, die unter Verwendung wäßriger oder organischer Lösungsmittel hergestellt werden, Stoffe ausscheiden. Dieser Vorgang, der seine Ursache in Dehydratations- oder Koagulationsvorgängen der zunächst gelösten Teilchen hat, tritt in besonderem Maße bei der Herstellung von Extrakten aus Crataegus oxyacantha auf. The invention relates to a method for producing a medicament on the basis of hawthorn extracts. It is known that herbal extracts that be prepared using aqueous or organic solvents, substances retire. This process, which is caused by dehydration or coagulation processes which has initially dissolved particles occurs to a particular degree during manufacture of extracts from Crataegus oxyacantha.

Diesen Nachteilen will die Erfindung abhelfen und derartige Extralçte schaffen, ohne daß die erwähnten inneren Zustandsänderungen auftreten. Bei der Zubereitung der Extrakte wird man nicht nur Idie Früchte von Crataegus oxyacantha verwenden, sondern auch bestrebt sein, die in den Blüten und Blättern dieser Pflanze bekanntlich auch vorhandenen kreislaufwirksamen Substanzen zu erfassen. The invention aims to remedy these disadvantages and such extras without the mentioned internal changes of state occurring. During the preparation the extracts will not only be used in the fruits of Crataegus oxyacantha, but also strive to be known in the flowers and leaves of this plant also to record existing substances that have an effect on the circulation.

Es wurde nun überraschenderweise gefunden, daß man pharmazeutische Zabereitungen erhält, die stabil sind und nicht altern, wenn man bei der Gewinnung der Extraktivstoffe eine ganz bestimmte Reihenfolge einhält, in der die genannten einzelnen Bestandteile der Pflanzen einer Extraktion unterworfen werden. It has now surprisingly been found that pharmaceutical Preparations are obtained that are stable and do not age when one is in the process of obtaining them the extractive substances adheres to a very specific order in which the named individual components of the plants are subjected to extraction.

Gemäß der Erfindung arbeitet man so, daß man zunächst eine Mazeration aus Blättern des Weißdorns mit alkoholisch-wässerigem Extraktionsmedium im Verhältnis 1: 5 durchführt. Den so erhaltenen Extrakt verwendet man nunmehr anschließend zur Perkolation von Blüten des Weißdorns ebenfalls ,imVerhältnis 1: 5. Als letztes wir,d mit der die Extraktivstoffe von Blättern und Blüten enthaltenden Lösung eine Extraktion der Früchte vorgenommen. Man erreicht hierdurch, daß die stufenweise durchzuführenden Extraktionen stets mit dem gleichen Extraktionsmedium durchgeführt werden und die Extraktion verbessert wird durch die als Extraktionsförderer in den einzelnen Stufen jeweils anwesenden Extraktivstoffe der vorgeschalteten Einzelfraktionierungen.According to the invention, one works in such a way that one first maceration from leaves of the hawthorn with alcoholic-aqueous extraction medium in proportion 1: 5 performs. The extract obtained in this way is now used subsequently for Percolation of flowers of the hawthorn also, in a ratio of 1: 5 with the solution containing the extractive substances of leaves and flowers, an extraction made of fruits. This ensures that the steps to be carried out Extractions are always carried out with the same extraction medium and the Extraction is improved by acting as an extraction conveyor in the individual stages any extractive substances present in the upstream individual fractionations.

Verfahren zur Herstellung von Weißdornauszügen Es hat sich als zweckmäßig herausgestellt, als Extraktionsmedium einen 30- bis 40°/oigen Alkohol zu verwenden.Process for the production of hawthorn extracts It has proven to be useful found to use a 30-40% alcohol as the extraction medium.

Beispiel 1 kg getrocknete Weißldornblätter werden mit 5 kg 300/oigem Athylalkohol 48 Stunden unter mehrmaligem Umrühren mazeriert. Nach Abpressen von den Blättern wird diese Lösung zur Perkolation von getrockneten Weißldornblüten verwendet. Man arbeitet im gleichen Verhältnis wie zuvor. Nach Abtrennen von den Blüten wird die Lösung verwendet zur Perkolation getrockneter Weißdornfrüchte. Example 1 kg of dried hawthorn leaves are mixed with 5 kg of 300 / oigem Ethyl alcohol macerated for 48 hours while stirring several times. After pressing In the leaves, this solution is used to percolate dried hawthorn blossoms used. You work in the same ratio as before. After separating from the Blossoms, the solution is used for percolating dried hawthorn fruits.

Claims (1)

PATENTANSPRUCH Verfahren zur Herstellung von Weißdornauszügen, dadurch gekennzeiAnet, daß die Extraktion stufenweise in der Reihenfolge Blatt, Blüte, Frucht derart durchgeführt wird, daß jeweils die in der vorhergehenden Stufe erhaltene Extraktionslösung zur Extraktion der nächsten Stufe verwendet wird. PATENT CLAIM Process for the production of hawthorn extracts, thereby Marked that the extraction is gradual in the order of leaf, flower, fruit is carried out so that each obtained in the previous step Extraction solution is used for the extraction of the next stage.
DEM42366A 1959-08-06 1959-08-06 Process for the production of hawthorn extracts Pending DE1103519B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEM42366A DE1103519B (en) 1959-08-06 1959-08-06 Process for the production of hawthorn extracts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM42366A DE1103519B (en) 1959-08-06 1959-08-06 Process for the production of hawthorn extracts

Publications (1)

Publication Number Publication Date
DE1103519B true DE1103519B (en) 1961-03-30

Family

ID=7304315

Family Applications (1)

Application Number Title Priority Date Filing Date
DEM42366A Pending DE1103519B (en) 1959-08-06 1959-08-06 Process for the production of hawthorn extracts

Country Status (1)

Country Link
DE (1) DE1103519B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003816A1 (en) * 1993-07-29 1995-02-09 Willmar Schwabe Gmbh & Co. Compositions of crataegus species, medicaments and their use for preventing sudden death due to cardiac arrest and reperfusion-caused cardiovascular lesions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003816A1 (en) * 1993-07-29 1995-02-09 Willmar Schwabe Gmbh & Co. Compositions of crataegus species, medicaments and their use for preventing sudden death due to cardiac arrest and reperfusion-caused cardiovascular lesions
US5925355A (en) * 1993-07-29 1999-07-20 Willmar Schwabe Gmbh & Co. Preparations of Crataegus species, pharmaceutical compositions and their use for preventing sudden death due to cardiac arrest and reperfusion-caused cardiovascular lesions

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