RU95121629A - CRYSTALLINE COMPLEX OF CYCLODEXTRIN WITH RANITIDINE HYDROCHLORIDE, METHOD FOR ITS PREPARATION AND CONTAINING ITS PHARMACEUTICAL COMPOSITIONS - Google Patents
CRYSTALLINE COMPLEX OF CYCLODEXTRIN WITH RANITIDINE HYDROCHLORIDE, METHOD FOR ITS PREPARATION AND CONTAINING ITS PHARMACEUTICAL COMPOSITIONSInfo
- Publication number
- RU95121629A RU95121629A RU95121629/14A RU95121629A RU95121629A RU 95121629 A RU95121629 A RU 95121629A RU 95121629/14 A RU95121629/14 A RU 95121629/14A RU 95121629 A RU95121629 A RU 95121629A RU 95121629 A RU95121629 A RU 95121629A
- Authority
- RU
- Russia
- Prior art keywords
- substance
- ranitidine hydrochloride
- cyclodextrin
- guest
- host
- Prior art date
Links
- VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 title claims 8
- 229960001520 Ranitidine Hydrochloride Drugs 0.000 title claims 7
- 229920000858 Cyclodextrin Polymers 0.000 title claims 6
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 239000000126 substance Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 2
- 239000007900 aqueous suspension Substances 0.000 claims 2
- 229960004853 betadex Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N β-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 2
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- 229960000620 Ranitidine Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
- 238000007738 vacuum evaporation Methods 0.000 claims 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N α-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims 1
- GDSRMADSINPKSL-HSEONFRVSA-N γ-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims 1
Claims (8)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9306024 | 1993-03-05 | ||
| HU93.6024 | 1993-03-05 | ||
| PCT/EP1994/000645 WO1994020091A1 (en) | 1993-03-05 | 1994-03-04 | Crystalline cyclodextrin inclusion complexes of ranitidine hydrochloride and process for their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU95121629A true RU95121629A (en) | 1998-03-27 |
| RU2143896C1 RU2143896C1 (en) | 2000-01-10 |
Family
ID=10984320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95121629A RU2143896C1 (en) | 1993-03-05 | 1994-03-04 | Crystalline complex of cyclodextrin with ranitidin hydrochloride, method of preparation thereof, and pharmaceutical compositions containing thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5665767A (en) |
| EP (1) | EP0687174B1 (en) |
| JP (1) | JPH09502698A (en) |
| AT (1) | ATE201990T1 (en) |
| CA (1) | CA2157190A1 (en) |
| CZ (1) | CZ224995A3 (en) |
| DE (1) | DE69427467T2 (en) |
| RU (1) | RU2143896C1 (en) |
| WO (1) | WO1994020091A1 (en) |
| ZA (1) | ZA941544B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA955582B (en) * | 1994-07-06 | 1996-02-26 | Group Services Proprietary Lim | Inclusion complexes of ranitidine |
| EP1367057B1 (en) * | 1996-11-18 | 2008-09-17 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilones E and F |
| WO2000010562A1 (en) * | 1998-08-18 | 2000-03-02 | Leonidov Nikolai B | Physically stable and x-ray amorphous form of hydrochloride ranitidine having an increased anti-ulcer activity and method for producing the same |
| GB9915231D0 (en) | 1999-06-29 | 1999-09-01 | Pfizer Ltd | Pharmaceutical complex |
| ITMI20012749A1 (en) * | 2001-12-21 | 2003-06-21 | Chiesi Farma Spa | PROCEDURE FOR THE PREPARATION BY MICROWAVE TREATMENT OF INCLUSION COMPOUNDS BETWEEN DRUG AND CYCLODESTRINE AND PRODUCTS OBTAINED |
| US20040202694A1 (en) * | 2003-04-11 | 2004-10-14 | Vascular Control Systems, Inc. | Embolic occlusion of uterine arteries |
| WO2006013039A2 (en) * | 2004-08-02 | 2006-02-09 | Chiesi Farmaceutici S.P.A. | A process for the preparation of a piroxicam: betacyclodextrin inclusion compound |
| SI2044043T2 (en) | 2006-06-16 | 2021-04-30 | H. Lundbeck A/S | 1- yš- (2, 4-dimethylphenylsulfanyl) -phenylćpiperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment |
| US8889243B2 (en) | 2012-08-16 | 2014-11-18 | 3M Innovative Properties Company | Mechanical fastening nets and methods of making the same |
| WO2021079183A1 (en) * | 2019-10-21 | 2021-04-29 | Sms Pharmaceuticals Limited | Isopropyl alcohol solvent free crystalline ranitidine hydrochloride form-2 which is free of nitrosamine (ndma) impurity |
| CA3167273A1 (en) * | 2020-03-19 | 2021-09-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Stabilization of compounds as cyclodextrin complexes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3346123A1 (en) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | PHARMACEUTICAL PREPARATIONS OF SUBSTANCES MEDICAL OR UNSTABLE IN WATER AND METHOD FOR THE PRODUCTION THEREOF |
| GB8506792D0 (en) * | 1985-03-15 | 1985-04-17 | Janssen Pharmaceutica Nv | Derivatives of y-cyclodextrin |
| EP0518930A4 (en) * | 1990-03-02 | 1993-09-15 | Australian Commercial Research & Development Limited | Cyclodextrin compositions and methods for pharmaceutical and industrial applications |
| IT1241417B (en) * | 1990-03-06 | 1994-01-14 | Vectorpharma Int | THERAPEUTIC COMPOSITIONS WITH CONTROLLED RELEASE OF DRUGS SUPPORTED ON CROSS-LINKED POLYMERS AND COATED WITH POLYMER FILM, AND THEIR PREPARATION PROCESS |
-
1994
- 1994-03-04 EP EP94909927A patent/EP0687174B1/en not_active Expired - Lifetime
- 1994-03-04 RU RU95121629A patent/RU2143896C1/en active
- 1994-03-04 JP JP6519579A patent/JPH09502698A/en active Pending
- 1994-03-04 WO PCT/EP1994/000645 patent/WO1994020091A1/en active IP Right Grant
- 1994-03-04 AT AT94909927T patent/ATE201990T1/en not_active IP Right Cessation
- 1994-03-04 CZ CZ952249A patent/CZ224995A3/en unknown
- 1994-03-04 ZA ZA941544A patent/ZA941544B/en unknown
- 1994-03-04 CA CA002157190A patent/CA2157190A1/en not_active Abandoned
- 1994-03-04 US US08/513,779 patent/US5665767A/en not_active Expired - Fee Related
- 1994-03-04 DE DE69427467T patent/DE69427467T2/en not_active Expired - Lifetime
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