RU94041682A - Method of synthesis of taxane derivatives - Google Patents

Method of synthesis of taxane derivatives

Info

Publication number
RU94041682A
RU94041682A RU94041682/04A RU94041682A RU94041682A RU 94041682 A RU94041682 A RU 94041682A RU 94041682/04 A RU94041682/04 A RU 94041682/04A RU 94041682 A RU94041682 A RU 94041682A RU 94041682 A RU94041682 A RU 94041682A
Authority
RU
Russia
Prior art keywords
general formula
radical
synthesis
taxane derivatives
gmeans
Prior art date
Application number
RU94041682/04A
Other languages
Russian (ru)
Inventor
Депрэ Доминик
Fr]
Пюликани Жан-Пьер
Original Assignee
Рон-Пуленк Роре С.А. (FR)
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. (FR), Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А. (FR)
Publication of RU94041682A publication Critical patent/RU94041682A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/04—Electrodes; Manufacture thereof not otherwise provided for characterised by the material
    • C25B11/042—Electrodes formed of a single material
    • C25B11/043—Carbon, e.g. diamond or graphene
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/04—Electrodes; Manufacture thereof not otherwise provided for characterised by the material
    • C25B11/042—Electrodes formed of a single material
    • C25B11/046—Alloys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

FIELD: organic chemistry. SUBSTANCE: electrochemical method of synthesis of taxane derivatives of the general formula(I) from the compound of the general formula(II). In general formula (I)Ar means aryl radical, Rmeans benzol radical or radical R-O-CO- in which Rmeans radical of alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, bicycloalkenyl, phenyl or heterocyclyl and R means hydrogen atom or acetyl radical. In general formula (II)Ar and R were defined as in general formula (I); R′ means acetyl radical or 2,2,2-trichloroethoxycarbonyl and Gmeans radical 2,2,2-trichloroethoxycarbonyl and Gmeans hydrogen atom. Compounds of the general formula (I)show strong antitumor properties. EFFECT: improved method of synthesis.

Claims (1)

Объектом изобретения является электрохимический способ получения производных таксана общей формулы I, указанной в описании, исходя из продукта общей формулы II, указанной в описании. Продукты общей формулы I имеют замечательные противоопухолевые свойства.The object of the invention is an electrochemical method for producing taxane derivatives of the general formula I specified in the description, based on the product of the general formula II specified in the description. The products of general formula I have remarkable antitumor properties.
RU94041682/04A 1992-03-13 1994-09-12 Method of synthesis of taxane derivatives RU94041682A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9203000 1992-03-13
FR9203000A FR2688518B1 (en) 1992-03-13 1992-03-13 PROCESS FOR THE PREPARATION OF TAXANE DERIVATIVES.

Publications (1)

Publication Number Publication Date
RU94041682A true RU94041682A (en) 1996-07-20

Family

ID=9427641

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94041682/04A RU94041682A (en) 1992-03-13 1994-09-12 Method of synthesis of taxane derivatives

Country Status (21)

Country Link
EP (1) EP0630428B1 (en)
JP (1) JPH07504461A (en)
KR (1) KR950700439A (en)
AT (1) ATE130053T1 (en)
AU (1) AU3756393A (en)
CA (1) CA2117552A1 (en)
CZ (1) CZ218694A3 (en)
DE (1) DE69300766T2 (en)
DK (1) DK0630428T3 (en)
ES (1) ES2079982T3 (en)
FI (1) FI944190A0 (en)
FR (1) FR2688518B1 (en)
GR (1) GR3018036T3 (en)
HU (1) HUT68282A (en)
MX (1) MX9301345A (en)
NO (1) NO943371L (en)
RU (1) RU94041682A (en)
SK (1) SK108494A3 (en)
TW (1) TW235961B (en)
WO (1) WO1993018210A1 (en)
ZA (1) ZA931800B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
DK1260223T3 (en) * 1993-03-22 2005-09-05 Univ Florida State Furyl or thienyl substituted side chain taxanes
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
US6103698A (en) * 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
SI2264172T1 (en) 2002-04-05 2017-12-29 Roche Innovation Center Copenhagen A/S Oligomeric compounds for the modulation of hif-1alpha expression
US7713738B2 (en) 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
AU2004303464B2 (en) 2003-12-23 2009-10-01 Santaris Pharma A/S Oligomeric compounds for the modulation of BCL-2
WO2006050732A2 (en) 2004-11-09 2006-05-18 Santaris Pharma A/S Lna oligonucleotides and the treatment of cancer
AU2005304112B2 (en) 2004-11-09 2009-06-04 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60187689A (en) * 1984-03-06 1985-09-25 Otsuka Chem Co Ltd Nanufacture of 3-exo-methylenecepham derivative
FR2601675B1 (en) * 1986-07-17 1988-09-23 Rhone Poulenc Sante TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2629818B1 (en) * 1988-04-06 1990-11-16 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF TAXOL
FR2664894A1 (en) * 1990-07-19 1992-01-24 Rhone Poulenc Sante NOVEL STREPTOGRAMIN DERIVATIVES AND THEIR PREPARATION.

Also Published As

Publication number Publication date
FI944190A (en) 1994-09-12
MX9301345A (en) 1993-09-01
NO943371D0 (en) 1994-09-12
AU3756393A (en) 1993-10-05
FR2688518B1 (en) 1994-05-06
CZ218694A3 (en) 1995-02-15
SK108494A3 (en) 1995-02-08
ES2079982T3 (en) 1996-01-16
DE69300766D1 (en) 1995-12-14
ATE130053T1 (en) 1995-11-15
NO943371L (en) 1994-09-12
TW235961B (en) 1994-12-11
CA2117552A1 (en) 1993-09-16
EP0630428B1 (en) 1995-11-08
FR2688518A1 (en) 1993-09-17
HU9402614D0 (en) 1994-11-28
KR950700439A (en) 1995-01-16
JPH07504461A (en) 1995-05-18
HUT68282A (en) 1995-04-03
DE69300766T2 (en) 1996-04-18
ZA931800B (en) 1993-09-30
WO1993018210A1 (en) 1993-09-16
DK0630428T3 (en) 1995-12-27
FI944190A0 (en) 1994-09-12
GR3018036T3 (en) 1996-02-29
EP0630428A1 (en) 1994-12-28

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