DK0630428T3 - Process for the preparation of taxane derivatives - Google Patents

Process for the preparation of taxane derivatives

Info

Publication number
DK0630428T3
DK0630428T3 DK93918756.3T DK93918756T DK0630428T3 DK 0630428 T3 DK0630428 T3 DK 0630428T3 DK 93918756 T DK93918756 T DK 93918756T DK 0630428 T3 DK0630428 T3 DK 0630428T3
Authority
DK
Denmark
Prior art keywords
radical
general formula
taxane derivatives
preparation
trichloro
Prior art date
Application number
DK93918756.3T
Other languages
Danish (da)
Inventor
Dominique Deprez
Jean-Pierre Pulicani
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0630428T3 publication Critical patent/DK0630428T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B3/00—Electrolytic production of organic compounds
    • C25B3/20—Processes
    • C25B3/25—Reduction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/04—Electrodes; Manufacture thereof not otherwise provided for characterised by the material
    • C25B11/042—Electrodes formed of a single material
    • C25B11/043—Carbon, e.g. diamond or graphene
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25B—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES FOR THE PRODUCTION OF COMPOUNDS OR NON-METALS; APPARATUS THEREFOR
    • C25B11/00—Electrodes; Manufacture thereof not otherwise provided for
    • C25B11/04—Electrodes; Manufacture thereof not otherwise provided for characterised by the material
    • C25B11/042—Electrodes formed of a single material
    • C25B11/046—Alloys

Abstract

Process for electrochemical preparation of taxane derivatives of general formula (I) based on a product of general formula (II). In general formula (I), Ar denotes an aryl radical, R1? is a benzoyl radical or R2?-O-CO- radical in which R2? is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical and R is a hydrogen atom of the acetyl radical. In general formula (II), Ar and R are defined as in general formula (I), R' is an acetyl or trichloro-2,2,2 ethoxycarbonyl radical and G1? is a trichloro-2,2,2 ethoxycarbonyl radical and G2? is a hydrogen atom. The products of general formula (I) have outstanding anti-tumoral properties.
DK93918756.3T 1992-03-13 1993-03-11 Process for the preparation of taxane derivatives DK0630428T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9203000A FR2688518B1 (en) 1992-03-13 1992-03-13 PROCESS FOR THE PREPARATION OF TAXANE DERIVATIVES.

Publications (1)

Publication Number Publication Date
DK0630428T3 true DK0630428T3 (en) 1995-12-27

Family

ID=9427641

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93918756.3T DK0630428T3 (en) 1992-03-13 1993-03-11 Process for the preparation of taxane derivatives

Country Status (21)

Country Link
EP (1) EP0630428B1 (en)
JP (1) JPH07504461A (en)
KR (1) KR950700439A (en)
AT (1) ATE130053T1 (en)
AU (1) AU3756393A (en)
CA (1) CA2117552A1 (en)
CZ (1) CZ218694A3 (en)
DE (1) DE69300766T2 (en)
DK (1) DK0630428T3 (en)
ES (1) ES2079982T3 (en)
FI (1) FI944190A (en)
FR (1) FR2688518B1 (en)
GR (1) GR3018036T3 (en)
HU (1) HUT68282A (en)
MX (1) MX9301345A (en)
NO (1) NO943371L (en)
RU (1) RU94041682A (en)
SK (1) SK108494A3 (en)
TW (1) TW235961B (en)
WO (1) WO1993018210A1 (en)
ZA (1) ZA931800B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
PT1227093E (en) * 1993-03-22 2005-09-30 Univ Florida State BETA-CACTAMAS UTEIS FOR THE PREPARATION OF TAXANS HAVING REPLACED LATERAL CHAIN WITH FURY OR TIENYL
US5760251A (en) * 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
DK2264172T3 (en) 2002-04-05 2017-11-27 Roche Innovation Ct Copenhagen As Oligomeric Compounds for Modulating HIF-1α Expression
US7713738B2 (en) 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
KR20070006709A (en) 2003-12-23 2007-01-11 산타리스 팔마 에이/에스 Oligomeric compounds for the modulation of bcl-2
US9447138B2 (en) 2004-11-09 2016-09-20 Roche Innovation Center Copenhagen A/S Potent LNA oligonucleotides for the inhibition of HIF-1a expression
BRPI0517613A (en) 2004-11-09 2008-10-14 Santaris Pharma As oligonucleotides lna and cancer treatment
EP1833840B9 (en) 2004-11-09 2010-11-10 Santaris Pharma A/S Potent lna oligonucleotides for the inhibition of hif-1a

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60187689A (en) * 1984-03-06 1985-09-25 Otsuka Chem Co Ltd Nanufacture of 3-exo-methylenecepham derivative
FR2601675B1 (en) * 1986-07-17 1988-09-23 Rhone Poulenc Sante TAXOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2629818B1 (en) * 1988-04-06 1990-11-16 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF TAXOL
FR2664894A1 (en) * 1990-07-19 1992-01-24 Rhone Poulenc Sante NOVEL STREPTOGRAMIN DERIVATIVES AND THEIR PREPARATION.

Also Published As

Publication number Publication date
GR3018036T3 (en) 1996-02-29
ATE130053T1 (en) 1995-11-15
CA2117552A1 (en) 1993-09-16
KR950700439A (en) 1995-01-16
HUT68282A (en) 1995-04-03
ZA931800B (en) 1993-09-30
TW235961B (en) 1994-12-11
DE69300766D1 (en) 1995-12-14
EP0630428B1 (en) 1995-11-08
JPH07504461A (en) 1995-05-18
EP0630428A1 (en) 1994-12-28
FI944190A0 (en) 1994-09-12
CZ218694A3 (en) 1995-02-15
DE69300766T2 (en) 1996-04-18
FR2688518B1 (en) 1994-05-06
SK108494A3 (en) 1995-02-08
FR2688518A1 (en) 1993-09-17
HU9402614D0 (en) 1994-11-28
AU3756393A (en) 1993-10-05
RU94041682A (en) 1996-07-20
FI944190A (en) 1994-09-12
WO1993018210A1 (en) 1993-09-16
NO943371D0 (en) 1994-09-12
NO943371L (en) 1994-09-12
MX9301345A (en) 1993-09-01
ES2079982T3 (en) 1996-01-16

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